Patents by Inventor Thomas Gadek

Thomas Gadek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Platelet aggregation inhibitors having high specificity for GPIIBIIIA
    Patent number: 5493007
    Abstract: A peptide containing the tripeptide recognition sequences RGD or KGD in a cycle and an exocyclic group bearing a positive charge is provided. The compound is provided in therapeutic form for administration to a mammal and exhibits high specificity and potency as a platelet aggregation inhibitor without undesireable side effects.
    Type: Grant
    Filed: September 23, 1994
    Date of Patent: February 20, 1996
    Assignee: Genentech, Inc.
    Inventors: John P. Burnier, Thomas Gadek, Robert S. McDowell
  • Benzazepine platelet aggregation inhibitors having specificity for the GPII.sub.b III.sub.a receptor
    Patent number: 5403836
    Abstract: A benzazepine derivative that acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
    Type: Grant
    Filed: May 6, 1993
    Date of Patent: April 4, 1995
    Assignee: Genentech, Inc.
    Inventors: Brent Blackburn, Robert McDowell, Thomas Gadek, Rob Webb
  • Nonpeptidyl platelet aggregation inhibitors having specificity for the GPII.sub.b III.sub. receptor
    Patent number: 5250679
    Abstract: A benzodiazepinedione derivative which acts as a nonpeptidyl platelet aggregation inhibitor is provided. This inhibitor potently inhibits fibrinogen binding to the GPII.sub.b III.sub.a receptor and is provided in therapeutic compositions for the treatment of diseases for which blocking platelet aggregation is indicated. These nonpeptidyl inhibitors are provided in combination with thrombolytics and anticoagulants.
    Type: Grant
    Filed: April 10, 1992
    Date of Patent: October 5, 1993
    Assignee: Genentech, Inc.
    Inventors: Brent Blackburn, Robert McDowell, Thomas Gadek, Peter Barker, Lawrence McGee, Rob Webb