Patents by Inventor Thomas Gainer

Thomas Gainer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibiting Eph B-3 kinase
    Patent number: 8927545
    Abstract: EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such as neuroprotective agents, comprising the EphB3 kinase inhibitor compounds are also provided. The EphB3 kinase inhibitor compounds and pharmaceutical compositions are useful, for example, to provide neuroprotection and/or repair of neuronal tissue damaged during an ischemic event, such as a stroke.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: January 6, 2015
    Assignees: Duke University, The Brigham and Women's Hospital, Inc.
    Inventors: Lixin Qiao, Marcie Glicksman, Thomas Gainer, Donald C. Lo, Ross L. Stein, Sungwoon Choi, Gregory D. Cuny
  • Inhibiting EPH B-3 Kinase
    Publication number: 20120238597
    Abstract: EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency for the inhibition of EphB3 kinase than general kinase inhibitors. Pharmaceutical compositions, such as neuroprotective agents, comprising the EphB3 kinase inhibitor compounds are also provided. The EphB3 kinase inhibitor compounds and pharmaceutical compositions are useful, for example, to provide neuroprotection and/or repair of neuronal tissue damaged during an ischemic event, such as a stroke.
    Type: Application
    Filed: March 30, 2010
    Publication date: September 20, 2012
    Applicants: DUKE UNIVERSITY, BRIGHAM & WOMEN'S HOSPITAL, INC.
    Inventors: Lixin Qiao, Marcie Glicksman, Thomas Gainer, Donald C. Lo, Ross L. Stein, Sungwoon Choi, Gregory D. Cuny