Abstract: A method for monitoring stimulation drift includes directing electrical stimulation through electrodes of a lead, wherein a selection of one or more electrodes and a stimulation amplitude for each of the one or more selected electrodes determines a stimulation position, wherein user programming of an implantable control module initially selects a primary stimulation position; modulating, over a time period of at least one day, the stimulation position around the primary stimulation position and delivering electrical stimulation at the modulated stimulation positions; for at least a plurality of the modulated stimulation positions and the primary stimulation position, receiving or observing a measure of stimulation effect; monitoring the measures of stimulation effect; and when the monitoring indicates a stimulation drift based on at least one drift criterion, performing at least one of the following: i) altering the primary stimulation position, or ii) generating a message.

Abstract: This document discusses, among other things, systems and methods for managing pain in a subject. A system may include a sensor circuit configured to sense one or more physiological signals. A pain analyzer circuit may generate from the physiological signals cardiovascular parameters indicative of arterial pulsatile activity or cardiac electrical activity, and generate a pain score using at least the cardiovascular parameters. The system may include a neurostimulator that can adaptively control the delivery of pain therapy by adjusting stimulation parameters based on the pain score.