Patents by Inventor Thomas George Christopher Hayhow

Thomas George Christopher Hayhow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND THEIR USE IN TREATING CANCER
    Publication number: 20230374007
    Abstract: The specification generally relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof, where A, Z, Y, RA, Linker and v have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts thereof in methods of treatment of the human or animal body, for example in the prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.
    Type: Application
    Filed: September 29, 2021
    Publication date: November 23, 2023
    Inventors: Iacovos Neal Michaelides, Ulf Börjesson, Thomas George Christopher Hayhow, Jason Grant Kettle, Gavin William Collie, Robert Ian Storer, Christoph Grebner, Matthew William Dampier Perry, Sharanjeet Kaur Bagal, Charlene Fallan
  • ESTROGEN RECEPTOR DEGRADING PROTACS
    Publication number: 20220169643
    Abstract: The specification generally relates to compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, where R1, R2, R3, R4, R6, R7, R8, Linker, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.
    Type: Application
    Filed: March 27, 2020
    Publication date: June 2, 2022
    Inventors: Bin YANG, Thomas George Christopher HAYHOW, Charlene FALLAN, James Stewart SCOTT, Coura Rosalie DIENE, Bernard Christophe BARLAAM, Johannes Wilhelmus Maria NISSINK
  • Pyridinone dicarboxamide for use as bromodomain inhibitors
    Patent number: 10927080
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: February 23, 2021
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
    Inventors: Stephen John Atkinson, Helen Elizabeth Aylott, Anthony William James Cooper, Emmanuel Hubert Demont, Lee Andrew Harrison, Thomas George Christopher Hayhow, Matthew J. Lindon, Alexander G. Preston, Jonathan Thomas Seal, Ian David Wall, Robert J. Watson, James Michael Woolven
  • Compounds and their use in treating cancer
    Patent number: 10519152
    Abstract: The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R1, R4, R5, R6, R7, Linker, X, Y, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts and prodrugs thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: December 31, 2019
    Assignee: AstraZeneca AB
    Inventors: Bin Yang, Jason Grant Kettle, Thomas George Christopher Hayhow, Timothy Gordon Rasmusson, Johannes Wilhelmus Maria Nissink, Charlene Fallan, Gillian McGregor Lamont
  • PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS
    Publication number: 20190359572
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
    Type: Application
    Filed: August 8, 2019
    Publication date: November 28, 2019
    Inventors: Stephen John ATKINSON, Helen Elizabeth AYLOTT, Anthony William James COOPER, Emmanuel Hubert DEMONT, Lee Andrew HARRISON, Thomas George Christopher HAYHOW, Matthew J. LINDON, Alexander G. PRESTON, Jonathan Thomas SEAL, Ian David WALL, Robert J. WATSON, James Michael WOOLVEN
  • 2-OXO-1,2-dihydropyridine-3,5-dicarboxamide compounds as bromodomain inhibitors
    Patent number: 10471050
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: November 12, 2019
    Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
    Inventors: Stephen John Atkinson, Emmanuel Hubert Demont, Lee Andrew Harrison, Thomas George Christopher Hayhow, Matthew J. Lindon, Alexander G. Preston, Jonathan Thomas Seal, Ian David Wall, Robert J. Watson, James Michael Woolven
  • Pyridinone dicarboxamide for use as bromodomain inhibitors
    Patent number: 10428026
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: October 1, 2019
    Assignee: GlaxoSmithKline Intellectual Property (No.2) Limited
    Inventors: Stephen John Atkinson, Helen Elizabeth Aylott, Anthony William James Cooper, Emmanuel Hubert Demont, Lee Andrew Harrison, Thomas George Christopher Hayhow, Matthew J. Lindon, Alexander G. Preston, Jonathan Thomas Seal, Ian David Wall, Robert J. Watson, James Michael Woolven
  • Pyridinone dicarboxamide for use as bromodomain inhibitors
    Patent number: 10370356
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
    Type: Grant
    Filed: September 20, 2016
    Date of Patent: August 6, 2019
    Assignee: GlaxoSmithKline Intellectual Property (No. 2) Limited
    Inventors: Stephen John Atkinson, Emmanuel Hubert Demont, Lee Andrew Harrison, Thomas George Christopher Hayhow, David House, Matthew J. Lindon, Alexander G. Preston, Jonathan Thomas Seal, Ian David Wall, Robert J. Watson, James Michael Woolven
  • Compounds and Their Use in Treating Cancer
    Publication number: 20190194190
    Abstract: The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts and prodrugs thereof, where R1, R4, R5, R6, R7, Linker, X, Y, A, G, D and E have any of the meanings defined herein. This specification also relates to the use of such compounds and pharmaceutically acceptable salts and prodrugs thereof in methods of treatment of the human or animal body, for example in prevention or treatment of cancer. This specification also relates to processes and intermediate compounds involved in the preparation of such compounds and to pharmaceutical compositions containing them.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 27, 2019
    Inventors: Bin YANG, Jason Grant KETTLE, Thomas George Christopher HAYHOW, Timothy Gordon RASMUSSON, Johannes Wilhelmus Maria NISSINK, Charlene FALLAN, Gillian McGregor Lamont
  • 2-OXO-1,2-DIHYDROPYRIDINE-3,5-DICARBOXAMIDE COMPOUNDS AS BROMODOMAIN INHIBITORS
    Publication number: 20180280368
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: October 3, 2016
    Publication date: October 4, 2018
    Inventors: Stephen John ATKINSON, Emmanuel Hubert DEMONT, Lee Andrew HARRISON, Thomas George Christopher HAYHOW, Matthew J. LINDON, Alexander G. PRESTON, Jonathan Thomas SEAL, Ian David WALL, Robert J. WATSON, James Michael WOOLVEN
  • PYRIDINONE DICARBOXAMIDE FOR USE AS BROMODOMAIN INHIBITORS
    Publication number: 20180258044
    Abstract: The present invention relates to compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and to their use in therapy
    Type: Application
    Filed: August 31, 2016
    Publication date: September 13, 2018
    Inventors: Stephen John ATKINSON, Helen Elizabeth AYLOTT, Anthony William James COOPER, Emmanuel Hubert DEMONT, Lee Andrew HARRISON, Thomas George Christopher HAYHOW, Matthew J. LINDON, Alexander G. PRESTON, Jonathan Thomas SEAL, Ian David WALL, Robert J. WATSON, James Michael WOOLVEN
  • Tetrahydroquinoline derivatives and their pharmaceutical use
    Patent number: 8697725
    Abstract: Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: April 15, 2014
    Assignee: GlaxoSmithKline LLC
    Inventors: Emmanuel Hubert Demont, Neil Stuart Garton, Romain Luc Marie Gosmini, Thomas George Christopher Hayhow, Jonathan Seal, David Matthew Wilson, Michael David Woodrow
  • Tetrahydroquinoline Derivatives And Their Pharmaceutical Use
    Publication number: 20120208798
    Abstract: Tetrahydroquinoline compounds of formula (I) and salts thereof, pharmaceutical compositions containing such compounds and their use in therapy.
    Type: Application
    Filed: November 3, 2010
    Publication date: August 16, 2012
    Inventors: Emmanuel Hubert Demont, Neil Stuart Garton, Romain Luc Marie Gosmini, Thomas George Christopher Hayhow, Jonathan Seal, David Matthew Wilson, Michael David Woodrow
  • PYRAZOLE COMPOUNDS AS PROSTAGLANDIN RECEPTORS LIGANDS
    Publication number: 20090239845
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein Z, R1, R2a, R2b, R10, R11 and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: April 24, 2006
    Publication date: September 24, 2009
    Inventors: Elizabeth Ann Conway, Gerard Martin Paul Giblin, Mairi Gibson, Adrian Hall, Thomas George Christopher Hayhow, Mark Patrick Healy, David Nigel Hurst, Ian Reginald Kilford, Stephen Carl McKeown, Alan Naylor, Helen Susanne Price, Derek Anthony Rawlings