Abstract: The present invention provides a method for assaying oxygenase activity, the method comprising monitoring oxygenase activity of FTO.

Abstract: The present invention provides a method for assaying oxygenase activity, the method comprising monitoring oxygenase activity of FTO.

Abstract: The invention relates to a method and system for controlling a compressor in a refrigerant circuit of an air-conditioning system of a motor vehicle. The instantaneous load torque is determined and compared with a maximum limiting torque prescribed by an engine controller, and the compressor is controlled depending on the comparison value resulting therefrom. In order to avoid complete shutdown of the compressor, the instantaneous load torque is represented as a function of variables, such as compressor speed and high pressure of the refrigerant, and, using an inverted function belonging to this function, a control signal for the compressor, for example, a set-point value for the high pressure of the refrigerant, is determined as a function of the maximum limiting torque and employed to control the compressor.

Abstract: Phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) by cyclic AMP-dependent protein kinase (PKA) is essential for opening the CFTR chloride channel. A short segment containing many negatively charged amino acids (817-838, NEG2) within the regulatory (R) domain of CFTR is a critical regulator of the chloride channel activity. An isolated NEG2 polypeptide may be expressed as a separate sequence that stimulates CFTR channel openings at lower concentrations, but that inhibits CFTR channel openings at higher concentrations. Residues in the NEG2 sequence were substituted to produce a polypeptide that exerts only an activating effect on CFTR. One such polypeptide is the Q4N2NEG2 polypeptide. Exogenous Q4N2NEG2 exerts stimulatory effects on both wild-type and mutant G551D CFTR function, without exhibiting inhibitory activity at any concentration.

Abstract: The invention relates to a method and system for controlling a compressor in a refrigerant circuit of an air-conditioning system of a motor vehicle. The instantaneous load torque is determined and compared with a maximum limiting torque prescribed by an engine controller, and the compressor is controlled depending on the comparison value resulting therefrom. In order to avoid complete shutdown of the compressor, the instantaneous load torque is represented as a function of variables, such as compressor speed and high pressure of the refrigerant, and, using an inverted function belonging to this function, a control signal for the compressor, for example, a set-point value for the high pressure of the refrigerant, is determined as a function of the maximum limiting torque and employed to control the compressor.