Abstract: The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD.

Abstract: The invention relates to a hybrid system for performing a magnetic resonance tomography (MRT) and a radiofrequency ablation on a patient, comprising the following characteristics: a) the hybrid system comprises a magnetic resonance tomography system in which MRT high-frequency signals for carrying out the magnetic resonance tomography can be generated and supplied on an output terminal of the magnetic resonance tomography system; b) the hybrid system comprises at least one ablation electrode for performing the radiofrequency ablation; and c) the at least one ablation electrode is coupled to the output terminal of the magnetic resonance tomography system such that the radiofrequency ablation can be carried out by the at least one ablation electrode by means of the MRT high-frequency signals. The invention also relates to a method for operating such a hybrid system.

Abstract: A wheel for a rail vehicle has a wheel tire (1) with a ridge (9) formed on the inner circumference of the wheel tire (1), a wheel body (3) with a ring flange (11) formed on the outer circumference and running radially outward, and a clamp ring (5) attached to the wheel body (3) via a fastening means (13), on a side face opposite the ring flange (11). Damping means formed as at least two separate circular ring segments (7) extend between the clamp ring (5) and the circumferential ridge and between the circumferential ridge (9) of the wheel tire (1) and the ring flange in the circumferential direction of the wheel. On at least one side, the circular ring segments (7) have at least two centering cams (19) meshing into corresponding recesses (21). The circular segments (7) have an elastomer core enclosed by metal sheet segments (17).

Abstract: A fuel injection system (10) for delivering metered amounts fuel into the combustion chamber or cylinder of an engine. The fuel delivered can selectively comprise a gaseous fuel, a liquid fuel or a fuel mixture comprising the gaseous fuel and the liquid fuel. When the fuel delivered comprises a mixture of the gaseous fuel and the liquid fuel, the quantity of liquid fuel comprises a metered quantity. The quantity of gaseous fuel also comprises a metered quantity, with the metering of the gaseous fuel being regulated by prediction. The injection event involves delivering the liquid fuel and the gaseous fuel, with the metering of the gaseous fuel delivered being adjusted to allow for the quantity of liquid fuel delivered with the gaseous fuel. The injection system (10) comprises a liquid fuel circuit (11) and a gaseous fuel circuit (13), both communicating with a fuel delivery injector (15) that delivers fuel to the combustion chamber.

Abstract: A wheel for a rail vehicle has a wheel tire (1) with a ridge (9) formed on the inner circumference of the wheel tire (1), a wheel body (3) with a ring flange (11) formed on the outer circumference and running radially outward, and a clamp ring (5) attached to the wheel body (3) via a fastening means (13), on a side face opposite the ring flange (11). Damping means formed as at least two separate circular ring segments (7) extend between the clamp ring (5) and the circumferential ridge and between the circumferential ridge (9) of the wheel tire (1) and the ring flange in the circumferential direction of the wheel. On at least one side, the circular ring segments (7) have at least two centering cams (19) meshing into corresponding recesses (21). The circular segments (7) have an elastomer core enclosed by metal sheet segments (17).

Abstract: A fuel rail assembly for direct injection of a gaseous fuel into an internal combustion engine comprises a fuel rail defining a flow passage for receiving gaseous fuel and a delivery injector for directly injecting fuel received from the fuel rail into a combustion chamber of the engine. The delivery injector is arranged having a selectively openable delivery port for delivery of gaseous fuel into the combustion chamber when the delivery port is in an open condition. The fuel rail assembly further comprises a valve operable so as to interrupt the flow of gaseous fuel to the delivery injector for delivery into the combustion chamber. A containment zone is defined between the valve and the delivery port when the delivery port is in a closed condition, whereby the containment zone is selected so as to be a prescribed volume.

Abstract: An injector has an inlet and an outlet and an armature tube having passage structure and having a distal end spaced from the outlet. The passage structure communicates with the inlet. A movable, magnetic armature is coupled to the armature tube. An electromagnetic coil is associated with a stator and with the armature. A first spring is constructed and arranged, when the coil is not activated, to bias the armature tube so that the distal end engages in a sealing manner with a first seat to limit leakage of the gaseous fuel from the outlet. A second valve is movable in a valve body. A second spring is constructed and arranged, when the coil is not activated, to bias the second valve so that a seating surface thereof engages a second seat to close the outlet.

Abstract: An injector has an inlet and an outlet and an armature tube having passage structure and having a distal end spaced from the outlet. The passage structure communicates with the inlet. A movable, magnetic armature is coupled to the armature tube. An electromagnetic coil is associated with a stator and with the armature. A first spring is constructed and arranged, when the coil is not activated, to bias the armature tube so that the distal end engages in a sealing manner with a first seat to limit leakage of the gaseous fuel from the outlet. A second valve is movable in a valve body. A second spring is constructed and arranged, when the coil is not activated, to bias the second valve so that a seating surface thereof engages a second seat to close the outlet.

Abstract: A fuel injection system (10) for delivering metered amounts fuel into the combustion chamber or cylinder of an engine. The fuel delivered can selectively comprise a gaseous fuel, a liquid fuel or a fuel mixture comprising the gaseous fuel and the liquid fuel. When the fuel delivered comprises a mixture of the gaseous fuel and the liquid fuel, the quantity of liquid fuel comprises a metered quantity. The quantity of gaseous fuel also comprises a metered quantity, with the metering of the gaseous fuel being regulated by prediction. The injection event involves delivering the liquid fuel and the gaseous fuel, with the metering of the gaseous fuel delivered being adjusted to allow for the quantity of liquid fuel delivered with the gaseous fuel. The injection system (10) comprises a liquid fuel circuit (11) and a gaseous fuel circuit (13), both communicating with a fuel delivery injector (15) that delivers fuel to the combustion chamber.

Abstract: The invention relates to a contact means (100) for attaching an end of a cable (110). The contact means (100) has a casing (300) with an inner chamber (320) for receiving a section of the cable (110) in the region of the cable end, and a pull relief element (200, 201, 202, 203) which can be fastened to the casing (300) in the inner chamber (320), with a pull relief section (220, 221, 222, 223) and at least one contacting section (240, 241). The pull relief section (220, 221, 222, 223) is formed to fix a cable sheath (120) of the cable (110). The contacting section (240, 241) is formed to contact a shield (130) of the cable (110).

Abstract: The invention relates to a contact means (100) for attaching an end of a cable (110). The contact means (100) has a casing (300) with an inner chamber (320) for receiving a section of the cable (110) in the region of the cable end, and a pull relief element (200, 201, 202, 203) which can be fastened to the casing (300) in the inner chamber (320), with a pull relief section (220, 221, 222, 223) and at least one contacting section (240, 241). The pull relief section (220, 221, 222, 223) is formed to fix a cable sheath (120) of the cable (110). The contacting section (240, 241) is formed to contact a shield (130) of the cable (110).

Abstract: Present invention relates to a device for reducing vibrations of a vibrating object as well as a method for reducing vibrations, wherein the perturbing vibrations are reduced drastically by induction of counter-forces. In general, vibrations of equal frequency (counter-vibration) as the perturbing vibration are generated. The force generated by the counter-vibration acts onto the vibrating object, whose amplitude of vibration is to be reduced. The phasing of the counter-vibration is antipodal to the vibration to be reduced, preferably the force of the generated counter-vibration is greater than the force being necessary for compensation of the perturbing vibration. The transfer of the force of the counter-vibration onto the vibrating object is affected by means of a magnetorheological or electrorheological material, whereby the absolute value of the transmitted force is adjusted by the magnitude of an applied magnetical or electric field.

Abstract: The present invention relates to a damping device having a first control element with a first surface (O1) and a second control element with a second surface (O2), the two control elements being moveable relative to each other with their two surfaces, a spatial region (intermediate space Z) which is filled at least partially with a magnetorheological and/or electrorheological material (M) and is disposed between the first and the second surface, and a field producer (4) with which a magnetic and/or electrical field can be produced in at least a partial region of the material-filled part of the intermediate space, and also a housing (1) which has two chambers (K1, K2) and in which a piston unit (2) which is moveable relative to the housing and a closing unit (3) which is moveable relative to the piston unit are disposed, the piston unit and the closing unit forming a throughflow opening (D) connecting the two chambers, through which a fluid (F) can be displaced between the two chambers by means of a relative m

Abstract: The present invention discloses a locking device having a control unit with a first control element with a first surface (O1) and a second control element with a second surface (O2), the two control elements being moveable relative to each other with their two surfaces, a spatial region (intermediate space Z) which is filled at least partially with a magnetorheological and/or electrorheological material (M) and is disposed between the first and the second surface, and a field producer (4) with which a magnetic and/or electrical field can be produced in at least a partial region of the material-filled part of the intermediate space, a locking unit with a piston unit (2) and a locking system (3) with which the piston unit can be locked, the two control elements being able to be coupled to each other by the field produced in the intermediate space and the locking state of locking system and piston unit being able to be changed by means of this coupling.

Abstract: The invention provides a gatherer stitcher having at least one stitching station (1) for stitching sheets, the stitching station being arranged on a stitching carriage that can move in the longitudinal direction (X) of a gatherer chain during the stitching operation and at least one ejector unit being provided after the stitching station in the transport direction of the sheets in order to eject the sheets, to provide a gatherer stitcher exhibiting a higher operational reliability as compared with the prior art. According to the invention, this is achieved in that at least one acceleration and/or braking unit (4) for accelerating and/or braking the sheets in the longitudinal direction (X) toward the ejector unit is arranged between the stitching carriage and the ejector unit.

Abstract: A stapling device (1) with at least two stapling heads (4, 5) attached to a stapling head unit (2) for stapling sheet-like material, in particular paper, cardboard or the like, is provided, wherein the distance between at least two stapling heads (4, 5) can be adjusted relative to each other. In a stapling device (1) according to the invention, the retrofitting necessary for various products is to be simplified. This is achieved in the invention by moveably arranging the stapling heads (4, 5) relative to each other, and providing a drive unit (9, 10) for setting the stapling head distance.