Patents by Inventor Thomas Ginko

Thomas Ginko has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of 11?-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17?-pregna-4,9-dien-3-one
    Patent number: 7910573
    Abstract: The present invention relates to crystalline forms of 11?-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17?-pregna-4,9-dien-3-one. The invention relates in particular to two crystalline ansolvate/anhydrate forms of this compound, polymorphs I and II. However, the present invention also relates to crystalline solvates, for example methanol and ethanol solvates of 11?-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17?-pregna-4,9-dien-3-one as precursors for preparing these two polymorphs I and II. Processes for preparing polymorph I by displacement crystallization or by trituration are described. Selection of the last solvent before formation of the ansolvate can be based on the differences in the purification behaviour of the individual solvates of 11?-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17?-pregna-4,9-dien-3-one. Polymorph I according to the invention is particularly suitable for the manufacture of medicinal products.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: March 22, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Wolfgang Beckmann, Gabriele Winter, Edda Kraemer, Thomas Ginko, Evelin Amoulong, Arwed Cleve
  • CRYSTALLINE FORMS OF 11SS-(4-ACETYLPHENYL)-20,20,21,21,21-PENTAFLUORO-17-HYDROXY-19-NOR-17A-PREGNA-4,9-DIEN-3-ONE
    Publication number: 20080085875
    Abstract: The present invention relates to crystalline forms of 11?-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17?-pregna-4,9-dien-3-one. The invention relates in particular to two crystalline ansolvate/anhydrate forms of this compound, polymorphs I and II. However, the present invention also relates to crystalline solvates, for example methanol and ethanol solvates of 11?-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17?-pregna-4,9-dien-3-one as precursors for preparing these two polymorphs I and II. Processes for preparing polymorph I by displacement crystallization or by trituration are described. Selection of the last solvent before formation of the ansolvate can be based on the differences in the purification behaviour of the individual solvates of 11?-(4-acetylphenyl)-20,20,21,21,21-pentafluoro-17-hydroxy-19-nor-17?-pregna-4,9-dien-3-one. Polymorph I according to the invention is particularly suitable for the manufacture of medicinal products.
    Type: Application
    Filed: June 1, 2007
    Publication date: April 10, 2008
    Inventors: Wolfgang Beckmann, Gabriele Winter, Edda Kraemer, Thomas Ginko, Evelin Amoulong, Arwed Cleve