Abstract: An apparatus is designed for holding the tail of an animal to one side while the animal is on a milking platform. The apparatus consists of a structure mounted to the rail along or around the milking platform which holds the tail such that the pathway to the udder between the animal's rear legs is unobstructed by the tail.

Abstract: A robotic milking system suitable for use with conventional milking clusters. Clusters are withdrawn to a generally known position upon release from a cow with the cups hanging down below the bowl. The cups are then located in a confined region from where they are picked up by a robotic arm and attached to teats of a cow. The arrangement allows a single robotic arm to service multiple bales of a rotary milking parlor.

Abstract: An apparatus is designed for holding the tail of an animal to one side while the animal is on a milking platform. The apparatus consists of a structure mounted to the rail along or around the milking platform which holds the tail such that the pathway to the udder between the animal's rear legs is unobstructed by the tail.

Abstract: Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression.

Abstract: A hardware integer saturation detector that detects both whether packing a 32-bit integer value causes saturation and whether packing each of first and second 16-bit integer values causes saturation, where the first 16-bit integer value is the upper 16 bits of the 32-bit integer value and the second 16-bit integer value is the lower 16 bits of the 32-bit integer value. The detector includes hardware signal logic, configured to generate four signals with information about the integer values. The hardware integer detector also includes saturation logic, configured to gate the four signals to generate a saturation signal. Each bit of the saturation signal indicates whether packing the 32-bit integer value or whether packing one of the first and second 16-bit integer values will cause saturation respectively.

Abstract: Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression.

Abstract: A robotic milking system suitable for use with conventional milking clusters. Clusters are withdrawn to a generally known position upon release from a cow with the cups hanging down below the bowl. The cups are then located in a confined region from where they are picked up by a robotic arm and attached to teats of a cow. The arrangement allows a single robotic arm to service multiple bales of a rotary milking parlour.

Abstract: Although it can be farnesylated, mutant lamin A expressed in Hutchinson Gilford Progeria Syndrome cannot be defarnesylated; the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (“progerin”) that alters normal lamin A function as a dominant negative, and assumes its own aberrant function through its association with the nuclear membrane. Retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) will inhibit formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies.

Abstract: A robotic milking system suitable for use with conventional milking clusters. Clusters are withdrawn to a generally known position upon release from a cow with the cups hanging down below the bowl. The cups are then located in a confined region from where they are picked up by a robotic arm and attached to teats of a cow. The cups may be located into recesses or slots or be drawn through a guide. The arrangement allows a single robotic arm to service multiple bales of a rotary milking parlor. The application of a vacuum to milking cups may be controlled by applying sufficient pressure to the pulsation line of a cup to collapse the cup liner when that cup is not attached to a teat or by bending a feed line to a cup to close the flow path.

Abstract: A hardware integer saturation detector that detects both whether packing a 32-bit integer value causes saturation and whether packing each of first and second 16-bit integer values causes saturation, where the first 16-bit integer value is the upper 16 bits of the 32-bit integer value and the second 16-bit integer value is the lower 16 bits of the 32-bit integer value. The detector includes hardware signal logic, configured to generate four signals with information about the integer values. The hardware integer detector also includes saturation logic, configured to gate the four signals to generate a saturation signal. Each bit of the saturation signal indicates whether packing the 32-bit integer value or whether packing one of the first and second 16-bit integer values will cause saturation respectively.

Abstract: A memory subsystem in a microprocessor includes a first-level cache, a second-level cache, and a prefetch cache configured to speculatively prefetch cache lines from a memory external to the microprocessor. The second-level cache and the prefetch cache are configured to allow the same cache line to be simultaneously present in both. If a request by the first-level cache for a cache line hits in both the second-level cache and in the prefetch cache, the prefetch cache invalidates its copy of the cache line and the second-level cache provides the cache line to the first-level cache.

Abstract: A microprocessor configured to access an external memory includes a first-level cache, a second-level cache, and a bus interface unit (BIU) configured to interface the first-level and second-level caches to a bus used to access the external memory. The BIU is configured to prioritize requests from the first-level cache above requests from the second-level cache. The second-level cache is configured to generate a first request to the BIU to fetch a cache line from the external memory. The second-level cache is also configured to detect that the first-level cache has subsequently generated a second request to the second-level cache for the same cache line. The second-level cache is also configured to request the BIU to refrain from performing a transaction on the bus to fulfill the first request if the BIU has not yet been granted ownership of the bus to fulfill the first request.

Abstract: Although it can be farnesylated, mutant lamin A expressed in Hutchinson Gilford Progeria Syndrome cannot be defarnesylated; the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (“progerin”) that alters normal lamin A function as a dominant negative, and assumes its own aberrant function through its association with the nuclear membrane. Retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) will inhibit formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression. Similarly, treatment with FTIs should improve disease status in progeria and other laminopathies.

Abstract: A microprocessor configured to access an external memory includes a first-level cache, a second-level cache, and a bus interface unit (BIU) configured to interface the first-level and second-level caches to a bus used to access the external memory. The BIU is configured to prioritize requests from the first-level cache above requests from the second-level cache. The second-level cache is configured to generate a first request to the BIU to fetch a cache line from the external memory. The second-level cache is also configured to detect that the first-level cache has subsequently generated a second request to the second-level cache for the same cache line. The second-level cache is also configured to request the BIU to refrain from performing a transaction on the bus to fulfill the first request if the BIU has not yet been granted ownership of the bus to fulfill the first request.

Abstract: A memory subsystem in a microprocessor includes a first-level cache, a second-level cache, and a prefetch cache configured to speculatively prefetch cache lines from a memory external to the microprocessor. The second-level cache and the prefetch cache are configured to allow the same cache line to be simultaneously present in both. If a request by the first-level cache for a cache line hits in both the second-level cache and in the prefetch cache, the prefetch cache invalidates its copy of the cache line and the second-level cache provides the cache line to the first-level cache.

Abstract: Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression.

Abstract: A BIU prioritizes L1 requests above L2 requests. The L2 generates a first request to the BIU and detects the generation of a snoop request and L1 request to the same cache line. The L2 determines whether a bus transaction to fulfill the first request may be retried and, if so, generates a miss, and otherwise generates a hit. Alternatively, the L2 detects the L1 generated a request to the L2 for the same line and responsively requests the BIU to refrain from performing a transaction on the bus to fulfill the first request if the BIU has not yet been granted the bus. Alternatively, a prefetch cache and the L2 allow the same line to be simultaneously present. If an L1 request hits in both the L2 and in the prefetch cache, the prefetch cache invalidates its copy of the line and the L2 provides the line to the L1.

Abstract: A robotic milking system suitable for use with conventional milking clusters. Clusters are withdrawn to a generally known position upon release from a cow with the cups hanging down below the bowl. The cups are then located in a confined region from where they are picked up by a robotic arm and attached to teats of a cow. The cups may be located into recesses or slots or be drawn through a guide. The arrangement allows a single robotic arm to service multiple bales of a rotary milking parlour. The application of a vacuum to milking cups may be controlled by applying sufficient pressure to the pulsation line of a cup to collapse the cup liner when that cup is not attached to a teat or by bending a feed line to a cup to close the flow path.

Abstract: Although it can be farnesylated, the mutant lamin A protein expressed in Hutchinson Gilford Progeria Syndrome (HGPS) cannot be defarnesylated because the characteristic mutation causes deletion of a cleavage site necessary for binding the protease ZMPSTE24 and effecting defarnesylation. The result is an aberrant farnesylated protein (called “progerin”) that alters normal lamin A function as a dominant negative, as well as assuming its own aberrant function through its association with the nuclear membrane. The retention of farnesylation, and potentially other abnormal properties of progerin and other abnormal lamin gene protein products, produces disease. Farnesyltransferase inhibitors (FTIs) (both direct effectors and indirect inhibitors) will inhibit the formation of progerin, cause a decrease in lamin A protein, and/or an increase prelamin A protein. Decreasing the amount of aberrant protein improves cellular effects caused by and progerin expression.

Abstract: A BIU prioritizes L1 requests above L2 requests. The L2 generates a first request to the BIU and detects the generation of a snoop request and L1 request to the same cache line. The L2 determines whether a bus transaction to fulfill the first request may be retried and, if so, generates a miss, and otherwise generates a hit. Alternatively, the L2 detects the L1 generated a request to the L2 for the same line and responsively requests the BIU to refrain from performing a transaction on the bus to fulfill the first request if the BIU has not yet been granted the bus. Alternatively, a prefetch cache and the L2 allow the same line to be simultaneously present. If an L1 request hits in both the L2 and in the prefetch cache, the prefetch cache invalidates its copy of the line and the L2 provides the line to the L1.