Abstract: Novel compounds of Formula (I) or pharmaceutically acceptable salts, prodrugs and biologically active metabolites thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

Abstract: The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors.

Abstract: A system is disclosed for detecting moisture in a garment. The system comprises at least one moisture detection portion integrated with the garment. Each moisture detection portion comprises a cathode and an anode and may also comprise a housing or panel surrounding the electrodes. The system also comprises at least one switching mechanism for receiving a positive voltage from the cathode and the anode of a moisture detection portion, when the cathode and the anode are in the presence of a polar liquid. Each switching mechanism comprises at least one switching component and at least one power source. Each switching mechanism supplies current from at least one of its power sources to at least one notification device or at least one transmitter, or both, when its switching components are activated.

Abstract: A family of compounds capable of inhibiting the activity of farnesyl transferase.

Abstract: A donor web for use in a thermal transfer printer comprises a foil having a transfer side and a non-transfer side. A layer of thermal transfer material is disposed on the transfer side of the foil material. Indicia is ink-jetted to the foil. The indicia includes information pertaining to at least one of the length of used foil and the length of unused foil so that an operator can determine whether there is enough foil left for a printing operation. Preferably, the indicia is disposed on the non-transfer side and at a longitudinal edge portion of the foil in order to not affect or otherwise damage the printing portion of the foil. Also, the indicia is preferably white or black ink in order to be clearly visible against various colors of the thermal transfer material. The indicia can also be disposed on a receiver web.

Abstract: Aspects of the invention related to a system for providing advance notice of impending contact between a stationary component and a rotating component in a turbine engine. For example, the system can be used to warn of potential contact between a seal holder and a rotor disk in the compressor section of the engine. In one embodiment, a pad or other component can be provided on the stationary seal holder. If the seal holder and the rotor disk approach each other during operation, the pad can contact the rotor disk prior to actual contact between the seal holder and the rotor disk. An optical and/or an acoustic signal can be generated by such contact. The signals can be detected remotely from the point of contact by a signal detection device, thereby avoiding the need to pass wires through the compressor section.

Abstract: A contact tip suitable for electric arc welding has a consumable electrode. The contact tip has a body which defines a bore through which the electrode is able to pass to enable electric current from a welding power supply to be transferred from the body to the electrode. The body, in part of the length of the bore between an inlet end and an outlet end, has at least one region (herein referred to as a primary contact region) at which the body is adapted to enable primary electrical contact with the electrode, and along a remainder part of the length of the bore, the body is adapted such that any secondary contact between the body and the electrode along the remainder part does not substantially short circuit the primary electrical contact in the primary contact region of the bore.

Abstract: A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.

Abstract: The invention concerns a product inhibiting transduction of G heterotrimeric protein signals combined with another anti-cancer agent, in particular farnesyltransferase inhibitors, taxol or gemcitabin, for simultaneous, separate or prolonged therapeutic use in cancer treatment.

Abstract: A method of treating cholera or travel diarrhea in a patient in need thereof by an effective amount of a compound of the formula wherein the substrates are defined in the specification or its non-toxic, pharmaceutically acceptable salts.

Abstract: A family of compounds capable of inhibiting the activity of farnesyl transferase.

Abstract: A compound or pharmaceutically acceptable salts thereof of Formula (I) wherein the substituents are as defined herein, which are useful as kinase inhibitors.

Abstract: A composition for treating cancer comprising an anti-tumorally effective amount of a product comprising at least one transduction inhibitor of heterotrimeric G protein signals and at least one other anti-cancer agent selected from the group consisting of prenyltransferase inhibitors, taxol and its analogues, gemcitabine and camptothecin and its analogues, administered simultaneously, separately or spread over a period of time and a pharmaceutical carrier.

Abstract: Claimed is a somatostatin agonist according to formula (I), D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2,??(I) or a pharmaceutically acceptable salt thereof, and uses thereof.

Abstract: The invention relates to the use of cysteine derivatives for preparing a medicament intended to treat diseases which result from the formation of the heterotrimeric G protein. These diseases include in particular diseases linked to the following biological functions or disorders: smell, taste, perception of the light, neurotransmission, neurodegeneration, endocrine and exocrine gland functions, autocrine and paracrine regulation, arterial tension, embryogenesis, benign cell proliferation, oncogenesis, viral infection, immunological functions, diabetes, obesity, and benign :and malign proliferative diseases. Said cysteine derivatives include in particular: bis-1,1?-[7-(2-amino-1-oxo-3-thiopropyl)-8-(cyclohexylmethyl)-2-(2-methoxyphenyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazine disulphide (I), and bis-1,1?-7-(2-amino-1-oxo-3-thiopropyl-(2-(1-naphtyl)-8-(2-methylpropyl)-5,6,7,8-tetrahydroimidazo[1.2a]pyrazin-7-yl) disulphide (II).

Abstract: An optical modulator includes first and second modulator segments. The first and second modulator segments form an optical signal path for an optical signal. The optical modulator also includes an electrical signal path capable of receiving and carrying a modulation signal, which is applied to the optical signal at the first and second modulation segments to generate a modulated optical signal. An inductive element may be disposed between electrical inputs to the first and second modulator segments. The optical modulator may be an electro-absorption modulator (EAM). The inductive element may be an inductor or a transmission line segment.

Abstract: A system comprising at least one liquid detector that has a cathode and an anode and at least one switching mechanism for receiving a positive voltage from the cathode and anode of a liquid detector. Each switching mechanism comprises at least one switching component that is connected with a power source. Each switching component supplying a current from its connected power source when the switching component is activated. Preferably, each switching component is activated, when the switching component receives a voltage that exceeds a threshold voltage. The system also comprises a base unit that communicates remotely or through direct connection with each switching mechanism. The base unit communicates with at least one application control device that is connected with at least one electronic control apparatus for preventing the undesirable condition.

Abstract: The apparatus and method described utilizes a discrete deposition process to apply materials to an optical substrate. The materials can be applied to an optical substrate to create an ophthalmic lens or apply a coating to a lens or other optical surface. Average surface roughness below 10 nanometers can be achieved using the described apparatus and method. Localized error is minimized to less than 1 micron over a 1 mm linear distance to avoid a lens anomaly such as a localized power distortion or power wave. Coating is applied to an entire substrate surface or selected portions. Material can be deposited on the optical substrate to provide the substrate with desired refracting properties. One or more surfaces of the substrate can be coated. Waste material is minimized and a uniform coating is applied for the improvement of optical qualities of the substrate.

Abstract: This disclosure concerns transceivers that include CDR bypass functionality. In one example, a 10 G XFP transceiver module includes integrated CDR functionality for reducing jitter. The 10 G XFP transceiver module also implements CDR bypass functionality so that the CDR can be bypassed at rate less than about 10 Gb/s, such as the Fibre Channel 8.5 Gb/s rate for example.