Patents by Inventor Thomas H. Cauley, III
Thomas H. Cauley, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11920700Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.Type: GrantFiled: February 15, 2019Date of Patent: March 5, 2024Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon
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Patent number: 11878302Abstract: System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.Type: GrantFiled: September 2, 2021Date of Patent: January 23, 2024Assignee: Bio-Rad Laboratories, Inc.Inventors: George Carman, Thomas H. Cauley, III, David P. Stumbo
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Publication number: 20240001364Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: ApplicationFiled: March 9, 2023Publication date: January 4, 2024Inventor: Thomas H. CAULEY, III
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Patent number: 11633736Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: GrantFiled: March 22, 2019Date of Patent: April 25, 2023Assignee: TALIS BIOMEDICAL CORPORATIONInventor: Thomas H. Cauley, III
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Publication number: 20220280081Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: August 17, 2020Publication date: September 8, 2022Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Publication number: 20220032306Abstract: Disclosed herein are methods and devices for preparing a dried reagent for long term storage and rehydrating and mixing the dried reagent.Type: ApplicationFiled: October 12, 2021Publication date: February 3, 2022Inventors: Thomas H. CAULEY III, Melvin YAMAMOTO
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Publication number: 20220020455Abstract: Methods are provided for operating an instrument to test samples suspected of containing a target pathogen in a near patient point of care environment. One embodiment of the method includes adding an identifying mark to a point of care cartridge and inserting the cartridge into an instrument. Additionally, interaction with a graphical user interface on the instrument can initiate the test sequence or eject the cartridge.Type: ApplicationFiled: July 14, 2020Publication date: January 20, 2022Inventors: Thomas H. CAULEY, III, Marc VALER SERRA
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Publication number: 20210394189Abstract: System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.Type: ApplicationFiled: September 2, 2021Publication date: December 23, 2021Inventors: George Carman, Thomas H. Cauley, III, David P. Stumbo
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Publication number: 20210369160Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: April 14, 2021Publication date: December 2, 2021Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Publication number: 20210331173Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: ApplicationFiled: March 22, 2019Publication date: October 28, 2021Applicant: TALIS BIOMEDICAL CORPORATIONInventor: Thomas H. CAULEY, III
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Patent number: 11110458Abstract: System, including methods and apparatus, for spacing droplets from each other and for detection of spaced droplets.Type: GrantFiled: February 3, 2014Date of Patent: September 7, 2021Assignee: Bio-Rad Laboratories, Inc.Inventors: George Carman, Thomas H. Cauley, III, David P. Stumbo
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Publication number: 20210251540Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: November 2, 2020Publication date: August 19, 2021Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Patent number: 11009150Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.Type: GrantFiled: November 25, 2019Date of Patent: May 18, 2021Assignee: Talis Biomedical CorporationInventors: Thomas H. Cauley, III, John Dixon
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Patent number: 11008627Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: GrantFiled: October 16, 2019Date of Patent: May 18, 2021Assignee: Talis Biomedical CorporationInventors: Sayeed Andeshmand, Thomas H. Cauley, III, John Dixon, David Glade, Hédia Maamar, Michael John McAdams, Dzam-Si Jesse Ng, David Alexander Rolfe
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Publication number: 20210116049Abstract: Rotary valves and methods of using, manufacturing, and storing the same are provided herein. The rotary valve includes a rotor and a stator, biased toward one another to form a fluid tight seal. In some implementations, the rotor comprises an integrated flow channel containing a porous solid support. Frequently, the interface between rotor and stator is made fluid-tight using a gasket. Some implementations of the rotary valve include a displaceable spacer to prevent the gasket from sealing against at least one of the rotor and stator prior to operation, wherein when the spacer is displaced, the gasket seals the rotor and stator together in a fluid-tight manner.Type: ApplicationFiled: February 15, 2019Publication date: April 22, 2021Applicant: Talis BioMedical CorporationInventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON
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Publication number: 20210047678Abstract: Methods and systems are provided for point-of-care nucleic acid amplification and detection. One embodiment of the point-of-care molecular diagnostic system includes a cartridge and an instrument. The cartridge can accept a biological sample, such as a urine or blood sample. The cartridge, which can comprise one or more of a loading module, lysis module, purification module and amplification module, is inserted into the instrument which acts upon the cartridge to facilitate various sample processing steps that occur in order to perform a molecular diagnostic test.Type: ApplicationFiled: October 16, 2019Publication date: February 18, 2021Inventors: Sayeed ANDESHMAND, Thomas H. CAULEY, III, John DIXON, David GLADE, Hédia MAAMAR, Michael John McADAMS, Dzam-Si Jesse NG, David Alexander ROLFE
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Publication number: 20210023560Abstract: This disclosure relates to an apparatus for simultaneously filling a plurality of sample chambers. In one aspect, the apparatus comprises a common fluid source and a plurality of independent, continuous fluidic pathways. Each independent, continuous fluidic pathway comprises a sample chamber and a pneumatic compartment. The sample chamber is connected to the common fluid source, and the pneumatic compartment is connected to the sample chamber. The sample chamber comprises, in part, an assay chamber. The assay chamber comprises a monolithic substrate and a plug having optically transmissive properties. In some embodiments, the assay chamber contains a magnetic mixing element. In some embodiments, the assay chamber is a double tapered chamber. In some embodiments, a ratio of a volume of the sample chamber to a volume of the pneumatic compartment is substantially equivalent for each fluidic pathway of the plurality of fluidic pathways.Type: ApplicationFiled: March 22, 2019Publication date: January 28, 2021Applicant: TALIS BIOMEDICAL CORPORATIONInventor: Thomas H. CAULEY, III
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Patent number: 10898895Abstract: This disclosure relates to an assembly for loading a sample liquid. The assembly comprises an entry port comprising an inlet and a gas vent, and a reservoir. The reservoir comprises a distal wall, a fin, and a continuous fluidic pathway. The fin comprises first and second surfaces and extends from the inlet towards the distal wall. The continuous fluidic pathway comprises a converging channel that is in fluidic communication with the inlet and is defined by the second surface of the fin, and a diverging channel that is defined by the first surface of the fin and is in fluidic communication with the gas vent. At a distal end of the fin, a width of the converging channel at most equals a width of the diverging channel, and the width of the converging channel at most equals a distance between the distal end of the fin and the distal wall.Type: GrantFiled: September 13, 2018Date of Patent: January 26, 2021Assignee: Talis Biomedical CorporationInventors: Thomas H. Cauley, III, David Alexander Rolfe, Marc Valer Serra
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Publication number: 20210008559Abstract: Disclosed herein are methods and devices for preparing a dried reagent for long term storage and rehydrating and mixing the dried reagent.Type: ApplicationFiled: December 8, 2017Publication date: January 14, 2021Inventors: Thomas H. CAULEY, III, Melvin YAMAMOTO
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Publication number: 20210008513Abstract: This disclosure relates to a magnetic mixing apparatus that mixes a sample contained in a mixing chamber using a stir bar, while minimizing the amount of contact between the stir bar and walls of the mixing chamber. In one aspect, the apparatus comprises a ferromagnetic stir bar contained in the mixing chamber, and a driving magnet and a driven magnet located on opposite sides of the mixing chamber. The driving magnet, the driven magnet, and the ferromagnetic stir bar are each capable of rotating about a respective axis. The driving magnet, the driven magnet, and the ferromagnetic stir bar are magnetically coupled such that rotation of the driving magnet induces rotation of the driven magnet and rotation of the driving magnet and the driven magnet induce rotation of the ferromagnetic stir bar. In some embodiments, rotation of the ferromagnetic stir bar within the mixing chamber mixes the sample contained within the mixing chamber.Type: ApplicationFiled: September 12, 2018Publication date: January 14, 2021Applicant: TALIS BIOMEDICAL CORPORATIONInventors: Thomas H. CAULEY, III, David ROLFE