Patents by Inventor Thomas H. Corbett
Thomas H. Corbett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8183379Abstract: The invention provides compounds of formula I: wherein Y is F or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof, and methods of inhibiting cancer cells.Type: GrantFiled: November 14, 2008Date of Patent: May 22, 2012Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Lisa Polin, Stuart T. Hazeldine, Thomas H. Corbett
-
Patent number: 7728007Abstract: The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: GrantFiled: October 29, 2008Date of Patent: June 1, 2010Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
-
Patent number: 7585863Abstract: The invention provides compounds of the formula: wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: GrantFiled: August 31, 2006Date of Patent: September 8, 2009Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
-
Patent number: 7507749Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agent. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: May 24, 2007Date of Patent: March 24, 2009Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
-
Publication number: 20090076073Abstract: The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: ApplicationFiled: October 29, 2008Publication date: March 19, 2009Inventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
-
Patent number: 7470788Abstract: The invention provides compounds of formula I: wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: September 9, 2005Date of Patent: December 30, 2008Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Lisa Polin, Stuart T. Hazeldine, Thomas H. Corbett
-
Patent number: 7241894Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: December 10, 2004Date of Patent: July 10, 2007Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
-
Patent number: 7109341Abstract: The invention provides compounds of the formula: wherein A, X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical compositions comprising a compound of the above formula or a salt thereof, intermediates useful for preparing a compound of the above formula, and therapeutic methods comprising administering a compound of the above formula or a salt thereof to a mammal in need thereof.Type: GrantFiled: July 3, 2003Date of Patent: September 19, 2006Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
-
Patent number: 6867219Abstract: The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.Type: GrantFiled: July 31, 2002Date of Patent: March 15, 2005Assignee: Wayne State UniversityInventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
-
Publication number: 20040132618Abstract: The invention provides compounds of the formula: 1Type: ApplicationFiled: July 3, 2003Publication date: July 8, 2004Inventors: Jerome P. Horwitz, Thomas H. Corbett, Eduardo Palomino, Lisa Polin, Stuart T. Hazeldine
-
Publication number: 20030158088Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.Type: ApplicationFiled: December 17, 2002Publication date: August 21, 2003Applicant: Advanced Research and Technology Institute, Inc.Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
-
Publication number: 20030144321Abstract: The invention provides compounds of formula I: 1Type: ApplicationFiled: July 31, 2002Publication date: July 31, 2003Inventors: Jerome P. Horwitz, Stuart T. Hazeldine, Thomas H. Corbett, Lisa Polin
-
Patent number: 6573296Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.Type: GrantFiled: April 16, 1999Date of Patent: June 3, 2003Assignee: Advanced Research and Technology Institute, Inc.Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
-
Publication number: 20020019439Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.Type: ApplicationFiled: April 16, 1999Publication date: February 14, 2002Inventors: PAUL A. GRIECO, D. JAMES MORRE, THOMAS H. CORBETT, FREDERICK A. VALERIOTE
-
Patent number: 6013626Abstract: A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.Type: GrantFiled: March 7, 1995Date of Patent: January 11, 2000Assignees: The University of Hawaii, Wayne State UniversityInventors: Richard E. Moore, Marcus A. Tius, Russell A. Barrow, Jian Liang, Thomas H. Corbett, Frederick A. Valeriote, Trimurtulu Golakoti, Thomas K. Hemscheidt
-
Patent number: 5965493Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.Type: GrantFiled: May 1, 1997Date of Patent: October 12, 1999Assignees: Advanced Research and Technology Institute, Inc., The Board of Governors of Wayne State University, Purdue Reseach FoundationInventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
-
Patent number: 5955423Abstract: A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.Type: GrantFiled: June 7, 1995Date of Patent: September 21, 1999Assignees: The University of Hawaii, Wayne State UniversityInventors: Richard E. Moore, Charles D. Smith, Gregory M. L. Patterson, Susan L. Mooberry, Thomas H. Corbett, Frederick A. Valeriote, Trimurtulu Golakoti
-
Patent number: 5952298Abstract: A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.Type: GrantFiled: June 7, 1995Date of Patent: September 14, 1999Assignees: The University Of Hawaii, Wayne State UniversityInventors: Richard E. Moore, Charles D. Smith, Gregory M.L. Patterson, Susan L. Mooberry, Thomas H. Corbett, Frederick A. Valeriote, Trimurtulu Golakoti
-
Patent number: 5849748Abstract: The present invention includes purified and isolated quassinoids and synthetically derived quassinoid analogs based on a picrasane carbon skeleton. Novel sidechains at C-15 incorporating water solubilizing agents such as glycine are discussed. Therapeutic methods taking advantage of anticancer, antiviral, and herbistatic properties of these quassinoids are disclosed, including use against solid tumors and human immunodeficiency virus infected cells.Type: GrantFiled: June 13, 1997Date of Patent: December 15, 1998Assignee: Advanced Research and Technology Institute, Inc.Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote
-
Patent number: 5639712Abstract: Quassinoid compounds, compositions, and methods of using them for treating cells and solid tumors, and inhibiting plant growth.Type: GrantFiled: November 4, 1994Date of Patent: June 17, 1997Assignees: Indiana University Foundation, Purdue Research Foundation, Bd. of Governors of Wayne State Univ.Inventors: Paul A. Grieco, D. James Morre, Thomas H. Corbett, Frederick A. Valeriote