Patents by Inventor Thomas H. Graham

Thomas H. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8569299
    Abstract: Compounds of structural formulas I-1 and I-2 are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: October 29, 2013
    Assignee: Merck Sharp & Dohme Corp
    Inventors: Thomas H. Graham, Wensheng Liu, Iyassu K. Sebhat, Dong-Ming Shen, Zhi-Cai Shi
  • Publication number: 20130217660
    Abstract: Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Application
    Filed: May 12, 2011
    Publication date: August 22, 2013
    Inventors: Dong-Ming Shen, John S. Debenham, Thomas H. Graham, Matthew J. Clements, Yong Zhang
  • Publication number: 20130143859
    Abstract: Compounds of structural formulas I-1 and I-2 are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Application
    Filed: June 3, 2011
    Publication date: June 6, 2013
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Thomas H. Graham, Wensheng Liu, Iyassu K. Sebhat, Dong-Ming Shen, Zhi-Cai Shi
  • Publication number: 20130030019
    Abstract: Compounds of structural formula (I) are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
    Type: Application
    Filed: April 21, 2011
    Publication date: January 31, 2013
    Inventors: Thomas H. Graham, Dong-Ming Shen, Min Shu
  • Patent number: 5517747
    Abstract: A coaxial-to-coplanar waveguide connector is used for interconnecting stripline compatible devices utilizing coaxial cable. The connector is formed at the end of a length of coaxial cable embedded within a circuit board. The connector generally has a substantially semi-circular connection section. The connection section includes a conductor partly surrounded by an electrically insulative dielectric which is partly surrounded by a shield. An electrically conductive sheet is used to couple the shield to a ground plane of the circuit board. Electrically conductive ribbon is connect the conductor to a stripline compatible device. The coaxial-to-coplanar waveguide connector may be fabricated by coating a dielectric board with an adhesive material and then routing a length of miniature coaxial cable in the adhesive. Conductive material and dielectric material are consecutively laid upon the dielectric cable board.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: May 21, 1996
    Assignee: AIL Systems, Inc.
    Inventors: John A. Pierro, Thomas H. Graham, Scott M. Weiner, Paul Heller, Joseph L. Merenda
  • Patent number: 5402088
    Abstract: A coaxial-to-coplanar waveguide connector is used for interconnecting stripline compatible devices utilizing coaxial cable. The connector is formed at the end of a length of coaxial cable embedded within a circuit board. The connector generally has a substantially semi-circular connection section. The connection section includes a conductor partly surrounded by an electrically insulative dielectric which is partly surrounded by a shield. An electrically conductive sheet is used to couple the shield to a ground plane of the circuit board. Electrically conductive ribbon is connect the conductor to a stripline compatible device. The coaxial-to-coplanar waveguide connector may be fabricated by coating a dielectric board with an adhesive material and then routing a length of miniature coaxial cable in the adhesive. Conductive material and dielectric material are consecutively laid upon the dielectric cable board.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: March 28, 1995
    Assignee: AIL Systems, Inc.
    Inventors: John A. Pierro, Thomas H. Graham, Scott M. Weiner, Paul Heller, Joseph L. Merenda
  • Patent number: 5119049
    Abstract: An ultraminiature delay line assembly for use with an electronic system. The delay line is utilized for producing and introducing a known controllable time delay to an electrical signal without the accompanying signal attenuation normally associated with traditional coaxial delay lines. The ultraminiature delay line utilizes miniature coaxial transmission cable which is smaller in diameter than the coaxial transmission cable traditionally used. An ultraminiature delay line includes a thin substrate supporting base plate. Mounted on the thin substrate supporting base plate are numerous concentrically wound miniature coaxial cable assemblies. Coupled to the middle of each miniature coaxial cable assembly is a signal amplifying device having variable programmable gain which offsets signal attenuation caused by the length of miniature coaxial cable.
    Type: Grant
    Filed: April 12, 1991
    Date of Patent: June 2, 1992
    Assignee: Ail Systems, Inc.
    Inventors: Paul Heller, John A. Pierro, Thomas H. Graham, Scott M. Weiner