Abstract: A device (1) for crimping connection elements (2). The device (1) comprises a machine frame (5), at least one punch, a drive assembly, at least one anvil (17), and a working chamber (31). The punch (3) is preferably arranged in a movable manner in relation to the machine frame (5). The punch (3) contains at least one working surface (4) for deforming a connection element (2). The drive assembly for moving the punch (3) is connected to the punch. The anvil (17) is connected to the machine frame (5) and has a receiving surface (8) for the connection element (2). The working chamber is located between the punch and the anvil and is opened and closed by a relative movement between the punch and the anvil. The device has at least one sonotrode, by which the receiving surface (8) of the anvil (17) is supplied with ultrasound.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?) which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?) which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: A sonotrode (18) for producing a welded and/or soldered join between a cable (17) and a sheath (17), covering the cable (17), comprising at least one working surface (2). The working surface (2) is curved in a concave manner, at least in sections. An anvil (10) comprises at least one counter surface (11) which is curved in a concave manner, at least in sections. The device for producing the join between a cable (17) and a sheath (17), covering the cable (17), comprises a sonotrode (18) joined to an ultrasound source (8) at least at a joining surface (5), and comprising an anvil (10) arranged opposite the working surface (2) of the sonotrode (18). A method for producing a join between a cable (17) and a sheath (17) covering the cable (17) is also disclosed.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?), which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: A device (1) for crimping connection elements (2). The device (1) comprises a machine frame (5), at least one punch, a drive assembly, at least one anvil (17), and a working chamber (31). The punch (3) is preferably arranged in a movable manner in relation to the machine frame (5). The punch (3) contains at least one working surface (4) for deforming a connection element (2). The drive assembly for moving the punch (3) is connected to the punch. The anvil (17) is connected to the machine frame (5) and has a receiving surface (8) for the connection element (2). The working chamber is located between the punch and the anvil and is opened and closed by a relative movement between the punch and the anvil. The device has at least one sonotrode, by which the receiving surface (8) of the anvil (17) is supplied with ultrasound.

Abstract: A sonotrode (18) for producing a welded and/or soldered join between a cable (17) and a sheath (17), covering the cable (17), comprising at least one working surface (2). The working surface (2) is curved in a concave manner, at least in sections. An anvil (10) comprises at least one counter surface (11) which is curved in a concave manner, at least in sections. The device for producing the join between a cable (17) and a sheath (17), covering the cable (17), comprises a sonotrode (18) joined to an ultrasound source (8) at least at a joining surface (5), and comprising an anvil (10) arranged opposite the working surface (2) of the sonotrode (18). A method for producing a join between a cable (17) and a sheath (17) covering the cable (17) is also disclosed.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?), which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: The invention relates to a method for determination of the frequency of regulatory T-cells in samples obtained from human blood and to methods for the preparation of compositions comprising predetermined amount of regulatory T-cells. The invention is based on the conception that a large fraction of regulatory T-cells present in human peripheral blood do not express detectable amounts of Foxp3, the master transcription factor used for identification of regulatory T-cells, as a result of cytokine deprivation outside of the tissue context.

Abstract: The invention relates to the use of monoclonal antibodies which are specific for CD28 and activate the T lymphocytes of several up to all subgroups without the occupation of an antigen receptor of the T lymphocytes and which therefor activate said lymphocytes in an antigen unspecific manner or the invention relates to the use of an analogue thereof for producing a pharmaceutical composition in the form of a preparation or a preparation packet for treating virus infections in humans or lower warm-blooded animals having infected T lymphocytes. The pharmaceutical composition additionally contains a virus inhibitor. The invention also relates to a corresponding pharmaceutical composition and a treatment plan including the pharmaceutical composition.

Abstract: The invention relates to a protein or peptide comprising the C?-D loop of a member of the CD28 family, uses thereof and mAbs obtainable therefrom.

Abstract: The invention teaches a method for testing a prospective or known immunomodulatory drug for T-cell activation, comprising the step of contacting in-vitro a peripheral blood mononuclear cell (PBMC) culture with a predetermined amount of the prospective or known immunomodulatory drug and observing the PBMC culture for T-cell activation using a readout system, upon contact with the prospective or known immunomodulatory drug, wherein the cell density of a PBMC preculture is adjusted such that cell-cell contact of the PBMC is enabled and wherein the PBMC preculture is cultured for at least 12 h.

Abstract: The invention relates to the use of monoclonal antibodies which are specific for CD28 and activate the T lymphocytes of several up to all subgroups without the occupation of an antigen receptor of the T lymphocytes and which therefor activate said lymphocytes in an antigen unspecific manner or the invention relates to the use of an analogue thereof for producing a pharmaceutical composition in the form of a preparation or a preparation packet for treating virus infections in humans or lower warm-blooded animals having infected T lymphocytes. The pharmaceutical composition additionally contains a virus inhibitor. The invention also relates to a corresponding pharmaceutical composition and a treatment plan including the pharmaceutical composition.

Abstract: The invention relates to microparticles with a support structure and CD28-specific superagonistic monoclonal antibodies (mAbs) bonded to the support structure or a compound mimicking the above.

Abstract: The invention relates to a method for connecting a cable to an electrical connection element (14), in particular a plug connector, cable shoe or similar, during which the connection elements (14) are transported successively by a transport unit (6, 7) to an ultrasonic welding device (8), each of the connection elements (14) is brought into contact with a cable end section in the ultrasonic welding device (8) and is then connected by ultrasonic welding. To increase the production speed of a cable provided with a connection element (14), it is suggested according to the invention that the next connection element (14) to be connected is transported by the transport unit (6, 7) to the ultrasonic welding device (8) during production of the ultrasonic welded connection.

Abstract: The invention teaches the application of monoclonal antibodies being specific for CD28 and activating T lymphocytes of several to all sub-groups without occupying an antigen receptor of the T lymphocytes and thus in an antigen-unspecific manner, or an analogue thereto, for producing a pharmaceutical composition in an embodiment as a preparation or preparation package for treating virus infections of the human body or of the body of a lower warm-blooded animal with infected T lymphocytes, and wherein the pharmaceutical composition further contains a virus inhibitor, a corresponding pharmaceutical composition and a treatment plan using the pharmaceutical composition.