Abstract: The present invention concerns a neuroglobin, a nucleic acid coding for such a protein and a method for the preparation of such a protein. The invention in addition concerns antibodies directed against the protein and the use of the DNA and the protein for diagnosis and/or treatment of diseases of the nervous system.

Abstract: Splice variants of a human “TUB” antisense gene have been discovered, which overlap with human TUB and murine “tub” in antisense orientation. The overlapping portions suggest a regulatory/attenuation effect, due to RNA-RNA-interaction. These findings demonstrate that these TUB antisense constructs can regulate weight disorders, such as obesity, and progressive sensorineural degeneration phenotypes of the central nervous system. Accordingly, the invention provides therapeutic methods utilizing these constructs, as well as methods for identifying compounds that can therapeutically treat weight disorders.

Abstract: The present invention concerns a neuroglobin, a nucleic acid coding for such a protein and a method for the preparation of such a protein. The invention in addition concerns antibodies directed against the protein and the use of the DNA and the protein for diagnosis and/or treatment of diseases of the nervous system.