Abstract: The present ivention relates to a high through put screening method for assaying the non-, pro-, or anti-apoptonic or proliferative or necrotic activity of test compounds in cells, using vectors coding for a specific marker protein, cell lines and spheroids transfected with said vectors.

Abstract: The present invention relates to a method for the determination of non-, anti-, or pro-apoptotic and necrotic conditions of cells, newly designed vectors coding for marker proteins, cell lines transfected with such vector, and a method to assay the non-, pro- or anti-apoptotic or necrotic activity of test compounds.

Abstract: The present invention relates to a method for the determination of non-, anti-, or pro-apoptotic and necrotic conditions of cells, newly designed vectors coding for marker proteins, cell lines transfected with such vector, and a method to assay the non-, pro- or anti-apoptotic or necrotic activity of test compounds.

Abstract: An engine brake arrangement for a multi-cylinder internal combustion engine with at least one throttle valve per cylinder which, during braking operation of the internal combustion engine, is opened at times to connect a cylinder space with an exhaust conduit. To permit simple control of the opening and closing periods of the throttle valves, the latter are actuated by a hydraulic fluid, which is pumped by a pump with a single pressure-increasing and pumping element, and is distributed in a distributor with rotating channels to the individual conduits leading to a particular throttle valve.

Abstract: The invention relates to an internal-combustion engine-braking device and comprises a throttle valve actuated by a control piston both of which are arranged in a controlled bore in a cylinder head. To ensure lubrication of the control piston in a simple way, the control bore is equipped with a connecting orifice to the oil return bore leading from the engine rocker-arm space into the crankcase.