Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract: The present invention relates to methods and compositions for stabilizing proteins. The invention provides compositions comprising at least one tardigrade disordered protein (TDP) and at least one heterologous polypeptide and/or peptide of interest. Further provided are methods for stabilizing proteins and for producing organisms and cells having increased tolerance to desiccation and/or drought.

Abstract: Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Abstract: Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.

Abstract: In some examples, a system may include a housing attachable to a column and including a turn fitting and a receiver. The turn fitting may be movable relative to the receiver and along an axis of the housing between a neutral state and an attached state. In the neutral state, the turn fitting may be disposed at a first axial location along the axis of the housing. In the attached state, the turn fitting may be disposed at a second axial location along the axis of the housing.

Abstract: Methods, systems, and devices for supporting security for private data inputs to artificial intelligence models are described. A device (e.g., an application server) may receive a request to run an artificial intelligence model. The device may run the artificial intelligence model on a public data set and an extended set of data that includes both the public data set and a private data set. The device may determine a first set of outcomes based on running the artificial intelligence model on the public data set and a second set of outcomes based on rerunning the model on the extended set of data. The device may then compare the two sets of outcomes to determine whether a private data value is identifiable based on the second set of outcomes. If a private data value is identifiable, the device may obfuscate the results prior to transmitting the results to the requestor.

Abstract: A method for using a distributed ledger (DL) of a blockchain applicable to a network of blockchain nodes is provided.

Abstract: A system performs optical character recognition (OCR) on an image displaying a portion of an object. An image classification system identifies the object in the image, based on which one or more object detection models identify labels associated with the object within the image. The system determines text of the identified labels using OCR, and analyzes the OCR resultant text for discrepancies and/or inaccuracies. In response to identifying a discrepancy, the system provides a recommendation for improving the accuracy of the OCR resultant text.

Abstract: A neck exercise device and system are disclosed. An implementation of the device can include a head harness having an adjustable headband and a first cranial strap having each end attached to the headband. The device can further include a plurality of attachment members.

Abstract: A neck exercise device and system are disclosed. An implementation of the device can include a head harness having an adjustable headband and a first cranial strap having each end attached to the headband. The device can further include a plurality of attachment members.

Abstract: In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter. The first gasket and the second gasket may include a beveled surface adjacent to the filter. The first channel and the second channel may include a diameter of from about 0.01 mm to about 0.5 mm. A finger tightening system may securely hold the filter without any leaks.

Abstract: Systems, methods, and apparatuses for implementing a behavioral responsive adaptive context engine for emotionally-responsive experiences are disclosed.

Abstract: A neck exercise device and system are disclosed. An implementation of the device can include a head harness having an adjustable headband and a first cranial strap having each end attached to the headband. The device can further include a plurality of attachment members.

Abstract: Artificial intelligence (AI) oversight may be added to a multiparty engagement, such as a conference between devices having user interfaces. The AI may apply visual indicators, e.g., informational elements, recommendations, or other data, on one or more user interface. Visual indicators assist with presenting or participating in a conference. Visual indicators may highlight, e.g., AI-determined attributes of participants in the conference. Attributes may be derived physiological characteristics of participants, such as mood, apparent interest, paying attention, as well as AI-derived data from analyzing data sources, such as data about the participant, past engagements, time zone, name/title and other information to facilitate interaction with the participant. The AI may also review data for past deals, resume, project plans, social media, customer relationship manager data, and the like and develop models to allow it to monitor a conference and provide recommendations to facilitate conference goals.

Abstract: A neck exercise device and system are disclosed. An implementation of the device can include a head harness having an adjustable headband and a first cranial strap having each end attached to the headband. The device can further include a plurality of attachment members.

Abstract: A neck exercise device and system are disclosed. An implementation of the device can include a head harness having an adjustable headband and a first cranial strap having each end attached to the headband. The device can also include a second cranial strap having each end attached to the headband and an adjustable chin strap. The device can further include a plurality of attachment members.

Abstract: In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter. The first gasket and the second gasket may include a beveled surface adjacent to the filter. The first channel and the second channel may include a diameter of from about 0.01 mm to about 0.5 mm. A finger tightening system may securely hold the filter without any leaks.

Abstract: In some examples, a filter assembly may include a filter including a first gasket having a first channel adjacent to a first side of the filter and a second gasket having a second channel adjacent to a second side of the filter. The first gasket and the second gasket may include a beveled surface adjacent to the filter. The first channel and the second channel may include a diameter of from about 0.01 mm to about 0.5 mm. A finger tightening system may securely hold the filter without any leaks.

Abstract: A neck exercise device and system are disclosed. An implementation of the device can include a head harness having an adjustable headband and a first cranial strap having each end attached to the headband. The device can also include a second cranial strap having each end attached to the headband and an adjustable chin strap. The device can further include a plurality of attachment members.

Abstract: Methods, systems, and devices for supporting security for private data inputs to artificial intelligence models are described. A device (e.g., an application server) may receive a request to run an artificial intelligence model. The device may run the artificial intelligence model on a public data set and an extended set of data that includes both the public data set and a private data set. The device may determine a first set of outcomes based on running the artificial intelligence model on the public data set and a second set of outcomes based on rerunning the model on the extended set of data. The device may then compare the two sets of outcomes to determine whether a private data value is identifiable based on the second set of outcomes. If a private data value is identifiable, the device may obfuscate the results prior to transmitting the results to the requestor.