Patents by Inventor Thomas Hartung

Thomas Hartung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210284648
    Abstract: The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: June 3, 2021
    Publication date: September 16, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Patent number: 11040977
    Abstract: The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: June 22, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Publication number: 20200121725
    Abstract: The present invention relates to novel compositions and methods to produce 3D organ equivalents of the brain (i.e. “mini-brains”). The invention also relates to methods of using human induced pluripotent stem cells, a combination of growth and other soluble factors and gyratory shaking. Cells from healthy or diseased donors or animals can be used to allow testing different genetic backgrounds. The model can be further enhanced by using genetically modified cells, adding micro-glia or their precursors or indicator cells (e.g. with reporter genes or tracers) as well as adding endothelial cells to form a blood-brain-barrier.
    Type: Application
    Filed: December 2, 2019
    Publication date: April 23, 2020
    Inventors: Thomas Hartung, David Pamies, Helena T. Hogberg
  • Publication number: 20190194210
    Abstract: The invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Patent number: 10246460
    Abstract: The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: April 2, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Patent number: 10227308
    Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: March 12, 2019
    Assignees: HOFFMANN-LA ROCHE INC., EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRCIH, UNIVERSITÄT ZÜRICH
    Inventors: Simon M. Ametamey, Juergen Fingerle, Luca Gobbi, Uwe Grether, Ahmed Haider, Thomas Hartung, Linjing Mu, Leo Nicholls, Mark Rogers-Evans, Christoph Ullmer
  • Patent number: 9784753
    Abstract: Preparations containing deep-frozen blood are used for test procedures for determining blood response.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: October 10, 2017
    Inventors: Albrecht Wendel, Thomas Hartung
  • Publication number: 20170166534
    Abstract: The present invention relates to a compound of formula (I) wherein R1 is defined as in the description and in the claims. The compound of formula (I) can be used as radiolabeled ligand.
    Type: Application
    Filed: February 27, 2017
    Publication date: June 15, 2017
    Applicants: Hoffmann-La Roche Inc., EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH, UNIVERSITÄT ZÜRICH
    Inventors: Simon M. Ametamey, Juergen Fingerle, Luca Gobbi, Uwe Grether, Ahmed Haider, Thomas Hartung, Linjing Mu, Leo Nicholls, Mark Rogers-Evans, Christoph Ullmer
  • Publication number: 20160280712
    Abstract: The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Benno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels
  • Publication number: 20160031878
    Abstract: The present invention relates to radiolabeled compounds of formula I wherein R1, R2, R3 and R4 are as defined herein.
    Type: Application
    Filed: July 30, 2015
    Publication date: February 4, 2016
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Edilio BORRONI, Alexander FLOHR, Luca GOBBI, Thomas HARTUNG, Raphael HOAREAU, Michael HONER, Laurent MARTARELLO
  • Patent number: 8398192
    Abstract: An ink delivery device (30) for the ink supply of an inking system (20) of a printing machine (10) with ink, includes an ink reservoir (31), a drive that is connected to the ink reservoir (31) and configured such that the ink reservoir (31) can be pressurized by the drive, and a control device for controlling the drive of the ink delivery device (30), in which the drive and the control device are configured and connected with each other such that the ink delivery device (30) can be operated based on a method, in which the method includes the following steps: initiating an ink delivery process, increasing the pressure in the ink reservoir to a target operating pressure, adjusting the pressure in the ink reservoir to an adjusted operating pressure, and terminating the ink delivery process.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: March 19, 2013
    Assignee: Technotrans AG
    Inventor: Thomas Hartung
  • Publication number: 20130005588
    Abstract: Described herein are methods for establishing the non-toxicity of a substance. For example, described herein are methods for the construction of a comprehensive database of toxicity associated pathways and methods of using such a database.
    Type: Application
    Filed: March 15, 2011
    Publication date: January 3, 2013
    Inventor: Thomas Hartung
  • Patent number: 8153679
    Abstract: The present invention relates to novel radiolabelled inhibitors of formula I for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality. wherein R1 is isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy; and R2 is a radiolabelled group CH3, wherein the radionuclide is 3H or 11C. The radiolabelled compounds of formula I may be used as PET (Positron Emission Tomography) radiotracer for the labelling and diagnostic molecular imaging of the glycine 1 transporter functionality.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: April 10, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Daniela Alberati, Edilio Maurizio Borroni, Thomas Hartung, Roger David Norcross, Emmanuel Pinard
  • Publication number: 20110001774
    Abstract: An ink delivery device (30) for the ink supply of an inking system (20) of a printing machine (10) with ink, includes an ink reservoir (31), a drive that is connected to the ink reservoir (31) and configured such that the ink reservoir (31) can be pressurized by the drive, and a control device for controlling the drive of the ink delivery device (30), in which the drive and the control device are configured and connected with each other such that the ink delivery device (30) can be operated based on a method, in which the method includes the following steps: initiating an ink delivery process, increasing the pressure in the ink reservoir to a target operating pressure, adjusting the pressure in the ink reservoir to an adjusted operating pressure, and terminating the ink delivery process.
    Type: Application
    Filed: February 23, 2009
    Publication date: January 6, 2011
    Applicant: TECHNOTRANS AG
    Inventor: Thomas Hartung
  • Patent number: 7745107
    Abstract: Testing of flowing media for microbial toxins via whole blood incubation in a flow vessel containing a separation element and assaying for mediators.
    Type: Grant
    Filed: March 25, 2002
    Date of Patent: June 29, 2010
    Inventor: Thomas Hartung
  • Publication number: 20100111862
    Abstract: The present invention relates to novel radiolabelled inhibitors of formula I for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality. wherein R1 is isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy; and R2 is a radiolabelled group CH3, wherein the radionuclide is 3H or 11C. The radiolabelled compounds of formula I may be used as PET (Positron Emission Tomography) radiotracer for the labelling and diagnostic molecular imaging of the glycine 1 transporter functionality.
    Type: Application
    Filed: October 28, 2009
    Publication date: May 6, 2010
    Inventors: Daniela Alberati, Edilio Maurizio Borroni, Thomas Hartung, Roger Norcross, Emmanuel Pinard
  • Publication number: 20080014101
    Abstract: A device for supplying ink to a printing press, includes a piston pump and a hydraulic or pneumatic cylinder driving mechanism which drives the piston rod of the piston pump and the cylinder driving mechanism includes several cylinder chambers, which are separated from one another and each of which contains a driving piston, which can be acted upon with pressure.
    Type: Application
    Filed: July 12, 2007
    Publication date: January 17, 2008
    Applicant: TECHNOTRANS AG
    Inventors: Thomas Hartung, Alexander Frank
  • Publication number: 20070197615
    Abstract: The present invention is concerned with a novel process for the preparation of compounds of formula (I) wherein R1 and R2 are as defined in the description and claims. The compounds of formula (I) are pharmaceutically active substances.
    Type: Application
    Filed: February 15, 2007
    Publication date: August 23, 2007
    Inventors: Thomas Hartung, Christian Jenny, Francois Montavon, Pius Waldmeier
  • Publication number: 20050090020
    Abstract: Preparations containing deep-frozen blood are used for test procedures for determining blood response.
    Type: Application
    Filed: January 22, 2004
    Publication date: April 28, 2005
    Inventors: Albrecht Wendel, Thomas Hartung
  • Publication number: 20040161766
    Abstract: Testing of flowing media for microbial toxins via whole blood incubation in a flow vessel containing a separation element and assaying for mediators.
    Type: Application
    Filed: April 7, 2004
    Publication date: August 19, 2004
    Inventor: Thomas Hartung