Abstract: The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3'kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (3,4,5)-triphosphate in response to activation of trimeric G protein-linked receptors. This novel protein, comprised of a catalytic subunit, p120, and a regulatory subunit, p101, is found in cells of hematopoietic origin and is involved in immune system responses which cause inflammation. The presence of p101 subunit is largely responsible for the dramatic stimulation of kinase activity in the presence of activated trimeric G proteins.

Abstract: The present invention relates to the discovery, identification and characterization of nucleotides that encode the G protein regulated phosphatidylinositol-3' kinase, a heterodimeric enzyme which produces the intracellular messenger phosphatidylinositol (3,4,5)-triphosphate in response to activation of trimeric G protein-linked receptors. This novel protein, comprised of a catalytic subunit, p120, and a regulatory subunit, p101, is found in cells of hematopoietic origin and is involved in immune system responses which cause inflammation. The presence of p101 subunit is largely responsible for the dramatic stimulation of kinase activity in the presence of activated trimeric G proteins.

Abstract: A cavity thickness compensated etalon filter. A tuning medium is placed in a Fabry-Perot etalon cavity. The index of refraction of the tuning medium varies as a function of voltage applied across the medium. The etalon is formed of two generally flat substrates disposed substantially parallel to one another. Each substrate has a layer of conductive material within the cavity adjacent the substrate. Each substrate also has a layer of reflective material within the cavity adjacent the substrate. At least one layer of reflective material is only partially reflective so as to enable light to pass into and out of the cavity. Liquid crystal material may be used as a tuning medium in the cavity. In the case of liquid crystal material, the etalon also comprises an alignment layer disposed within the cavity adjacent each substrate to pre-order the liquid crystal material.

Abstract: A component configuration for enhancing the serviceability of a dispenser includes a platform positionable on the housing of the dispenser. A refrigeration unit mounts at a center and rear portions of the platform. An electronic control is disposed within a housing that is mounted at a center portion of the platform adjacent to the refrigeration unit. The electronic control housing permits access to the electronic control from the front of the dispenser. An evaporator coil of the refrigeration unit includes concentric coil sections defined by an inner coil section, an intermediate coil section, and an outer coil section.

Abstract: An ultra-short optical pulse source uses a gain-switched laser diode with a dispersive delay line to compress the optical pulse output from the laser diode, the gain-switched laser diode having particular spectral characteristics. The gain-switched laser diode may be tested by energizing it with a continuous wave signal at or near the lasing threshold level. The resulting spectrum is examined for the presence of satellite spectral intensity features. Those gain-switched laser diodes that exhibit a spectrum having all satellite spectral features below a predetermined level with respect to the intensity of a principal spectral component are selected for use in the ultra-short optical pulse source.