Abstract: This invention relates to a hydroxamate metalloprotease inhibitor compound for use in a method of diagnosing or treating cancer, inflammatory diseases or Alzheimer's disease. The compound comprises a zinc-chelating N-hydroxamate moiety radiolabeled with a radionuclide. Radiolabeled compounds of the invention may be used in targeted radionuclide therapy wherein a patient is treated with a compound of the invention comprising a diagnostic radionuclide to identify the presence of a cancer or disease, followed by treatment with a compound of the invention comprising a therapeutic radionuclide to treat said cancer or disease.

Abstract: The present disclosure relates to a system and method for coordinated laser delivery and imaging during an interventional procedure. A method may include activating an imaging source to provide a pulsed imaging signal and activating a laser source to provide a pulsed laser signal while the imaging source remains activated. The method may include coordinating the pulsed laser signal and the pulsed imaging signal to output each pulse of the pulsed laser signal and each pulse of the pulsed imaging signal in non-overlapping time windows. A system may include a controller in communication with the laser source and the imaging source for coordinating the output of the laser signal and the imaging signal.

Abstract: The present disclosure relates to a system and method for coordinated laser delivery and imaging during an interventional procedure. A method may include activating an imaging source to provide a pulsed imaging signal and activating a laser source to provide a pulsed laser signal while the imaging source remains activated. The method may include coordinating the pulsed laser signal and the pulsed imaging signal to output each pulse of the pulsed laser signal and each pulse of the pulsed imaging signal in non-overlapping time windows. A system may include a controller in communication with the laser source and the imaging source for coordinating the output of the laser signal and the imaging signal.

Abstract: A preferred contact group centric interface for a communication device can be used to facilitate communications by a user. The user interface can be arranged to activate from a user's “home page” on the display, from an idle screen that is accessed after a timeout period expires, or any other appropriate mechanism that activates the preferred contact group centric experience. A user selects the preferred contact group from among an array of the user's contacts. Once the contact group is configured, a minimal number of navigation/selection features is necessary to activate any number of communication modes available to the contacts. The contact group is configured such that simple and quick navigation between the contact members is achieved. The contact group can be presented in 2D and 3D arrangements, in any number of list or geometric configurations. A pricing plan can optionally be tied to each member of the contact group.

Abstract: A method for verifying a set of policy instructions to be used by a policy decision point (PDP) in adjudicating access requests to protected resources. The policy instructions are in the form of Horn clauses or conditional tag-expressions that are validated against a known test policy or desired outcome. The policy instructions are then compiled into aggregate form. When a plurality of policy instructions creates a conflict, the policy instructions are hierarchically organized to resolve said conflict.

Abstract: A system for controlling file access on a mobile computing device. Policy conditions are held at a policy decision point (PDP) and can be dynamically modified at run-time. Access requests to a file or set of files are intercepted by an agent that subsequently brokers the adjudication of said request via a secure, encrypted and hidden back-channel where the requestor is never allowed access to or knowledge of either the adjudication process or the parameters associated with adjudication. The PDP then returns either an access approval or denial based on said policy conditions.

Abstract: Embodiments include a catheter system comprising an elongated housing having a housing channel disposed between a first proximal end and a first distal end. The first distal end includes a ramp, having an inclining proximal section and an apex section, and a nose section. The catheter system further includes a rail wire channel in communication with the ramp but not the nose section and a laser delivery member being at least partially disposed within the housing channel and movable therein. In some embodiments, the catheter system includes a rail wire fixedly attached to and terminating at the first distal end of the elongated housing, wherein the rail wire extends through the rail wire channel, and wherein the laser delivery member is slidably coupled to the rail wire.

Abstract: A system and devices for ablation and removal of occlusions from blood vessels is provided. Laser cutting systems and mechanical cutting systems are provided in catheter devices, the cutting systems operable to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation. Catheter systems comprise distal end features adapted to cut and remove at least portions of an occlusion that generally correspond to dimensions of an inner lumen of a catheter.

Abstract: Systems and methods are described for utilizing a secure environment on a mobile computing device for applying policy-based decision management in response to access requests from untrusted areas. A policy decision processor (PDP) within the secure environment provides a policy decision in response to an access query. A decision cache within the secure environment can be used to store policy decisions for faster resolution of access requests. Policy enforcement points (PEPs) are placed between external devices that are trying to access the device and the secured environment, where the PEPs are used to enforce the policy-based decision, and can be located either inside or outside the secure environment. Decision certificates can be formulated using validity information and timestamps, and used for validation policy certificates. Memory in non-secure areas can also be marked (colored) for use in performing trusted operations in order to optimize system resource usage.

Abstract: A system for performing coincident boot of computing devices having non-volatile memory and secure and non-secure partitions on the same System on Chip (SoC) or on a similarly capable computing device with secure division and separation of sensitive memory resources, secure protection of intellectual property during boot and post-boot, and support for secure interoperations between secure and non-secure states. The system packages components of the boot loader into a single signed and encrypted package. That package is loaded into the non-secure memory where it is verified before being extracted to the secure partition.

Abstract: A system and method for secure access to computing services in trusted computing environments. The present invention facilitates the execution of services in a secure environment by unsecure requestors where the requestor has no visibility into the secure environment. A remote service creates an encrypted data bundle (EDB) consisting of the request and associated data and transmits the EDB to the unsecure requestor. The EDB is then transmitted to the Trusted Service Receiver (TSR) in the secure environment that decrypts the EDB and determines if the request is valid and permissible. If valid and permissible, the TSR determines what secure service will be required and Trusted Services (TS) are invoked. TSR then collects results from each TS invoked and transmits the result according to the instructions in the request.

Abstract: The present disclosure is directed, in one embodiment, to a wire centering sheath system in which wires outwardly extend from a sheath to brace against a vessel wall. The wire centering sheath system may be used to center endovascular devices.

Abstract: Laser energy delivery devices and methods are provided. A laser energy delivery device for providing treatment to a subject may include a coupling adapted to couple to a laser energy generator. A sheath is coupled to the coupling, the sheath including a distal end adapted to be disposed in the subject. A plurality of transport members are carried by the coupling and the sheath, the plurality of transport members being adapted to receive laser energy at the coupling, transmit laser energy through the sheath, and deliver laser energy to the subject. A sensor is adapted to detect transmission of laser energy through at least one of the plurality of transport members.

Abstract: Laser energy delivery devices and methods are provided. A laser energy delivery device may include a housing, and a coupling is carried by the housing and adapted to couple to a laser energy generator. A sheath is carried by the housing, and the sheath includes a distal end adapted to be disposed in the subject. A plurality of transport members are carried by the sheath, and the plurality of transport members are adapted to receive laser energy at the coupling, transmit laser energy through the sheath, and deliver laser energy to the subject. A fluid-driven motor is carried by the housing and adapted to be driven upon receiving a fluid from a fluid source. A drive wire is carried by the sheath and eccentrically coupled to the distal end of the sheath, and the drive wire is adapted to be rotatably driven by the fluid-driven motor and rotates to eccentrically rotate the distal end of the sheath.

Abstract: Catheter devices for ablation and removal of occlusions from blood vessels and methods of using the same are provided. Catheter devices are useful to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation. Distal features of the catheter devices comprise arrangements of laser ablative or mechanical cutting features that generally provide enhanced surface areas and cutting functions. Spiral or helical arrangements are provided to aid in cutting operations.

Abstract: A system for policy-managed secure code execution and messaging for computing devices where each trusted application is managed independently of others and is not visible to unauthorized inspection or execution. If a file bundle received by the system contains metadata concerning the context of the file or its execution, the metadata is decrypted if necessary. If the file bundle containing the executable code is encrypted, its key is stored in a policy server to await adjudication of the request to execute. If the policy server allows execution of the executable code, the key stored in the policy server is used to decrypt the file bundle and the resulting executable code is stored as a trusted application in secure memory. Future requests to execute the trusted application are adjudicated by the policy server and enforced by the exclusive policy execution point associated with that trusted application in secure memory.

Abstract: A preferred contact group centric interface for a communication device can be used to facilitate communications by a user. The user interface can be arranged to activate from a user's “home page” on the display, from an idle screen that is accessed after a timeout period expires, or any other appropriate mechanism that activates the preferred contact group centric experience. A user selects the preferred contact group from among an array of the user's contacts. Once the contact group is configured, a minimal number of navigation/selection features is necessary to activate any number of communication modes available to the contacts. The contact group is configured such that simple and quick navigation between the contact members is achieved. The contact group can be presented in 2D and 3D arrangements, in any number of list or geometric configurations. A pricing plan can optionally be tied to each member of the contact group.

Abstract: Devices, methods and systems for removing unwanted tissue from within a patient's vasculature system are provided. Specifically, a laser ablation catheter having a tip with an open, arched-shaped cross section is described. The cross section of the tip enhances the catheter's ability to ablate, separate, and/or dilate the various layers within a patient's vasculature, thereby facilitating the removal undesirable lesions and fibrous tissue within a patient's vasculature.

Abstract: A system and method for policy-based active Data Loss Prevention (DLP) using a two-step process to first determine if an attempt to access a data object is governed by DLP policy, and if so, then applying the DLP policy to either allow or deny access. Attempts by an agent to access, create, modify, or distribute a data object are trapped by a policy execution point. A first query determines if DLP policies govern that access request. If they do, then the metadata is decrypted to form a second query to a policy decision point to adjudicate the access request. If the access request is allowed, then a second key is provided to decrypt the data object for further processing. The system further provides for the encryption of unencrypted data objects to protect them for all future access queries.

Abstract: Catheters for ablation and removal of occlusions from blood vessels are provided. Laser cutting systems and mechanical cutting systems are provided in catheter devices, the cutting systems operable to ablate, cut, dislodge, and otherwise remove occlusions within a blood vessel that may limit or prevent proper circulation. A helical or partially-helical inner surface structure is provided in the catheter, the structure operable to remove or translate dislodged material(s).