Abstract: This disclosure is directed to compounds and pharmaceutical compositions for treating and preventing viral diseases, as Covid-19. Among others, the invention relates to the use of immune cells and ribonucleases in the preparation and use of pharmaceutical formulations for the treatment of said disease.

Abstract: This disclosure is directed to compounds and pharmaceutical compositions for treating and preventing viral diseases, as Covid-19. Among others, the invention relates to the use of ribonucleases and bioxoms, exosomes or combination thereof in the preparations and use of pharmaceutical formulations for the treatment of said disease. In addition, the invention relates to the use of immune cells and ribonucleases in the preparation and use of pharmaceutical formulations for the treatment of said disease.

Abstract: The present disclosure provides methods for prophylactically treating a subject for viral infections comprising topically administering a ranpirnase composition. The disclosure also provides compositions that could be used for prophylactic treatment.

Abstract: The present disclosure provides methods for prophylactically treating a subject for viral infections comprising topically administering a ranpirnase composition. The disclosure also provides compositions that could be used for prophylactic treatment.

Abstract: The present disclosure provides methods for prophylactically treating a subject for viral infections comprising topically administering a ranpirnase composition. The disclosure also provides compositions that could be used for prophylactic treatment.

Abstract: The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.

Abstract: The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.

Abstract: The present invention relates to cellular proteins that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.

Abstract: The present invention relates to nucleic acid sequences and cellular proteins encoded by these sequences that are involved in infection or are otherwise associated with the life cycle of one or more pathogens.

Abstract: The present invention relates to a protein, ADAM10, ADAM10 nucleic acid sequences and ADAM10 proteins encoded by these sequences that are involved in infection by one or more pathogen such as a virus, a parasite, a bacteria or a fungus or are otherwise associated with the life cycle of a pathogen.

Abstract: The present invention relates to a protein, ADAM10, ADAM10 nucleic acid sequences and ADAM10 proteins encoded by these sequences that are involved in infection by one or more pathogen such as a virus, a parasite, a bacteria or a fungus or are otherwise associated with the life cycle of a pathogen.

Abstract: Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.

Abstract: Host nucleic acids and host proteins that participate in viral infection, such as human immunodeficiency virus (HIV), influenza A, and Ebola virus, have been identified. Interfering with or disrupting the interaction between a host nucleic acid or host protein and a virus or viral protein confers an inhibition of or resistance to infection. Thus, interfering with such an interaction in a host subject can confer a therapeutic or prophylactic effect against a virus. The sequences identified can be used to identify agents that reduce or inhibit viral infection.

Abstract: The present invention relates to crystalline Rab9 in complex with either GDP or the GTP analog Guanosine 5?-(?,?-imido) triphosphate (GppNHp), the three dimensional coordinates and structures of Rab9 in Rab9-GDP and Rab9-GppNHp complexes, and uses thereof for drug design. In particular, the present invention relates to methods for producing Rab9 crystals of sufficient quality to obtain a determination of the three dimensional structure of Rab9 to a high resolution in both its GTP-bound (on/active) and GDP-bound (off/inactive) conformations. The present invention also relates to a computer-readable medium encoded with the three dimensional coordinates of Rab9 in Rab9-GDP and Rab9-GppNHp complexes wherein, using a graphical display software program, the three dimensional coordinates create an electronic file that can be visualized on a computer capable of representing the electronic file as a three dimensional image.

Abstract: The present invention relates to tires suitable for bearing heavy loads, and to the use of a rubber composition to form the treads of such tires which delays the appearance of irregular wear on the treads of such tires during travel. The invention applies to tires for motor vehicles, such as heavy vehicles, construction vehicles or aircraft. The rubber composition comprises: an elastomeric matrix comprising majoritarily at least one diene elastomer having at one or more of its chain ends a functional group which is active for coupling to a reinforcing white filler, a reinforcing filler comprising at least 50% by weight a reinforcing white filler, and a reinforcing white filler/functionalized diene elastomer bonding agent. The present invention relates to tires suitable for bearing heavy loads, and to the use of the rubber composition to delay the appearance of irregular wear on the treads of such tires during travel.

Abstract: The present invention relates to tires suitable for bearing heavy loads, and to the use of a rubber composition to form the treads of such tires which delays the appearance of irregular wear on the treads of such tires during travel. The invention applies to tires for motor vehicles, such as heavy vehicles, construction vehicles or aircraft. The rubber composition comprises: an elastomeric matrix comprising majoritarily at least one diene elastomer having at one or more of its chain ends a functional group which is active for coupling to a reinforcing white filler, a reinforcing filler comprising at least 50% by weight a reinforcing white filler, and a reinforcing white filler/functionalized diene elastomer bonding agent. The present invention relates to tires suitable for bearing heavy loads, and to the use of the rubber composition to delay the appearance of irregular wear on the treads of such tires during travel.

Abstract: The present invention relates to tires suitable for bearing heavy loads, and to the use of a rubber composition to form the treads of such tires which delays the appearance of irregular wear on the treads of such tires during travel. The invention applies to tires for motor vehicles, such as heavy vehicles, construction vehicles or aircraft.

Abstract: The present invention relates to tires suitable for bearing heavy loads, and to the use of a rubber composition to form the treads of such tires which delays the appearance of irregular wear on the treads of such tires during travel. The invention applies to tires for motor vehicles, such as heavy vehicles, construction vehicles or aircraft.