Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular of oropharyngeal squamous cell carcinoma (OPSCC). The present invention furthermore relates to tumor-associated T-cell peptide epitopes that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A system, method and apparatus for configuring a node in a sensor network. A sensor service can enable sensor applications to customize the collection and processing of sensor data from a monitoring location. In one embodiment, sensor applications can customize the operation of nodes in the sensor network via a sensor data control system.

Abstract: The present disclosure is directed to embodiments of a kiosk including a chassis having a patient compartment and a medication compartment. A patient does not have access to the medication compartment in the patient compartment. A dispense structure extends from the patient compartment to the medication compartment such that a dosage of medication may be dispensed to the patient when within the patient compartment. After the medication is dispensed to the patient, a medical professional observes the patient ingest the medication through a video conference display within the patient compartment. A biometric scanner may be in electrical communication with a lock in mechanical cooperation with a door hingedly coupled to the chassis to limit access to the medication compartment. An insulated safe with an internal chamber wherein the internal chamber's temperature is regulated.

Abstract: In an embodiment, an integrated circuit includes transistors in different active regions, electrically isolated using single diffusion break isolation. The single diffusion break isolation includes a first dummy transistor that has a different threshold voltage than the transistors in either active region for which the single diffusion break is creating isolation. The first dummy transistor may have lower leakage current than transistors in either active region, creating effective isolation between the active regions and consuming relatively small amounts of power due to the lower leakage currents.

Abstract: The invention provides a method of suppressing gene expression, comprising providing a mammalian cell with a suppression target RNA molecule comprising a heterologous RNAi target site operatively linked to a RNA sequence from a gene of interest, or with a DNA encoding said suppression target RNA molecule; providing to the cell an inhibitory RNA that has a complementary nucleotide sequence to the heterologous RNAi target site; wherein binding of the inhibitory RNA to the heterologous RNAi target site suppresses gene expression of the operatively linked RNA sequence from the gene of interest; and wherein said heterologous RNAi target site has a size of at least 18 nucleotides in length. The invention further provides nucleic acids and cells suitable for such a method.

Abstract: The invention relates to a method for determining an X-ray image dataset of a target region of an object to be examined, wherein projection images showing the target region are captured by means of an X-ray detector and the X-ray image dataset is reconstructed from the projection images, wherein a first portion of the projection images is captured so as to be collimated onto the target region by the target region being irradiated with X-ray radiation by means of an X-ray device through at least one main radiation opening of a collimator assembly. The invention also relates to a corresponding apparatus for determining an X-ray image dataset of a target region of the object to be examined. The invention generally relates to the field of medical X-ray imaging, in particular with the aim of acquiring projections for reconstructing 2D computed-tomography images.

Abstract: Multi-die structures and methods of fabrication are described. In an embodiment, a multi-die structure includes a first die, a second die, and die-to-die routing connecting the first die to the second die. The die-to-die interconnection may be monolithically integrated as a chip-level die-to-die routing, or external package-level die-to-die routing.

Abstract: A system, method and apparatus for integrated building operations management. Nodes in the sensor network can be configured to interface with a building control system to exchange sensor-related information.

Abstract: The invention relates to a computer-assisted tomography (CT) system having the following features: a) at least one X-ray source, b) at least one patient couch for supporting a patient, c) at least one first X-ray detector, provided permanently or at least temporarily in the ray path of the X-rays radiated by the X-ray source through the patient couch, d) at least one second X-ray detector, provided permanently or at least temporarily in the ray path of the X-rays radiated by the X-ray source through the patient couch, e) at least one actuable drive mechanism, using which the first and/or second X-ray detector can be moved from a position in the ray path of the X-rays radiated by the X-ray source through the patient couch, to a position outside the ray path and vice versa, f) at least one electronic control device that is configured to actuate the drive mechanism.

Abstract: A device configured to autonomously attach a cap to a bottle in a childproof manner. The device may comprise a cap feed line and a bottle feed line. The device may further comprise a moving arm assembly comprising a cam-chuck component having a plurality of jaws configured to grip, lift, and lower a cap onto the bottle. The device may further comprise a slide compensation assembly configured to prevent over-application of force of the cap to the bottle. The device may further comprise a screw drive assembly configured to screw the cap onto the bottle as downward force is applied. The device may further comprise an optical assembly for detecting errors in picking up the cap.

Abstract: An automated system for preparing and assembling a collection of doses of a medication, such as liquid medication including but not limited to methadone and buprenorphine, for fast and accurate order fulfillment. The automated system and its components may be configured to occupy a small footprint for integration in a clinic. The automated system may feature a system for dispensing medication into medication bottles, capping and labeling the bottles, and organizing or collating a collection or group of medication doses into an array for fulfillment of the medication order.

Abstract: Multi-die structures and methods of fabrication are described. In an embodiment, a multi-die structure includes a first die, a second die, and die-to-die routing connecting the first die to the second die. The die-to-die interconnection may be monolithically integrated as a chip-level die-to-die routing, or external package-level die-to-die routing.

Abstract: A system, method and apparatus for configuring a node in a sensor network. A sensor service can enable sensor applications to customize the collection and processing of sensor data from a monitoring location. In one embodiment, sensor applications can customize the operation of nodes in the sensor network via a sensor data control system.

Abstract: A protective arrangement for a motor vehicle for protecting a high-voltage battery of the motor vehicle from the penetration of liquid. The protective arrangement has an electrical component connected to the high-voltage battery via a cable, which component has a drainage device with a drain opening and a closure, by which the drain opening can be released depending on the pressure, a cooling circuit with a circuit component arranged on the component housing, through which component a coolant can flow, and with a pump to pump coolant through the circuit component, and a control device, which is designed to control the pump depending on detection of at least a probable penetration of coolant into the component housing in such a way that an increased pump power is at least temporarily provided by the same if the pump is not yet in a state of maximum pump performance.

Abstract: Various structures that implement topside metal routing and backside metal routing in combination with vertical transistors are disclosed. The various structures include cells that form inverter devices, NAND devices, and MUX (multiplexer) devices. The disclosed cells include two or four vertical transistors with various connections made to the transistors that include either connected gate logic for inverter and NAND devices or disconnected gate logic for MUX devices.

Abstract: Various structures that implement topside metal routing and backside metal routing in combination with vertical transistors are disclosed. The various structures include a building block cell with a metal contact layer between the backside metal routing and the vertical transistors. Various connections can be made within the building block cell to form more complex structures such as, but not limited to, inverter devices, NAND devices, and MUX (multiplexer) devices.

Abstract: A system, method and apparatus for integrated building operations management. Nodes in the sensor network can be configured to interface with a building control system to exchange sensor-related information.

Abstract: Multi-die structures and methods of fabrication are described. In an embodiment, a multi-die structure includes a first die, a second die, and die-to-die routing connecting the first die to the second die. The die-to-die interconnection may be monolithically integrated as a chip-level die-to-die routing, or external package-level die-to-die routing.

Abstract: A system, method and apparatus for configuring a node in a sensor network. A sensor service can enable sensor applications to customize the collection and processing of sensor data from a monitoring location. In one embodiment, sensor applications can customize the operation of nodes in the sensor network via a sensor data control system.

Abstract: Multi-die structures and methods of fabrication are described. In an embodiment, a multi-die structure includes a first die, a second die, and die-to-die routing connecting the first die to the second die. The die-to-die interconnection may be monolithically integrated as a chip-level die-to-die routing, or external package-level die-to-die routing.