Abstract: A device for automated pumping and dispensing of single doses of opioid addiction medication to a user. The device includes a pumping platform, an outlet, and a cup dispensing component configured to dispense a cup onto the pumping platform. The device further includes a pumping mechanism configured to rotate and pump the opioid addiction medication into the cup. The device further includes a pusher wheel operatively coupled to the pumping platform, configured to cyclically rotate between positions. In one position, the pusher wheel pushes the pumping mechanism away and blocks the outlet. In another position, the pusher wheel moves such that the pumping mechanism rotates over the pumping platform and blocks the outlet. In another position, the pusher wheel pushes the cup from the pumping platform to the outlet and moves such that the outlet is exposed.

Abstract: Systems, apparatuses, and methods for placing cells in an integrated circuit are described. In various embodiments, an integrated circuit is divided into many partitions. In a first set of partitions susceptible to transistor latch-up, the many transistor gate stripes are connected to one of the power rails rather than left floating. The lengths of the transistor gate stripes are shortened for well tap cells in the first partition, but increased in a second partition susceptible for poor signal integrity. One or more implant layers are formed underneath the transistor gate stripes in each of the first and second partitions to adjust an amount of protection against transistor latch-up and poor signal integrity. An electrostatic discharge transistor is included with at least one source region of multiple source regions formed in a well with a same doping polarity as the at least one source region.

Abstract: A system for dispensing prepackaged single doses of a medication. The system includes a carousel made up of columns each containing single doses sharing a dosage size and a medication type, configured to rotate about an axis. A pushing mechanism is coupled to the columns, configured to push a selected single dose from a column onto the verification platform. The system further includes a biometric authentication mechanism for determining an identity of a patient based on biometric data to find a dosage order corresponding to their identity, and directing the rotation mechanism to rotate the dose in the dosage order in-line with the pushing mechanism. The system further includes a mechanism configured to dispense the selected single dose if the selected single dose matches the dosage order, and push the selected single dose into a rejection reservoir if the selected single dose does not match the dosage order.

Abstract: A method for remotely approving and dispensing medications directly to a patient for opioid addiction treatment. The method includes determining an identity of the patient, by a biometric sensing component and establishing remote communication between the patient and a medical official certified for treating opioid addiction. The method also includes transmitting a medical record corresponding to the patient to the medical official, generating, by the medical official, the opioid addiction treatment, generating an event record made up of the identity of the patient, the opioid addiction treatment, the medical record, and the medical official, and transmitting the event record to a dosing location.

Abstract: The present invention relates to a method for detecting and/or quantifying an analyte in a sample using mass spectrometry. The method of the invention comprises: extracting the analyte from the sample using solid phase extraction (SPE) so as to obtain an SPE extract comprising the analyte, concentrating the analyte, said concentrating comprising evaporating solvent from the SPE-extract; and detecting and/or quantifying the analyte in the sample using mass spectrometry.

Abstract: A medical imaging system repeatedly irradiates a capturing area of a patient with a radiation, acquires data from the irradiated area of the patient and generates images from such acquired data. The system is arranged for automatic adaptive adjustment of at least one parameter of the system influencing the image quality of the generated images dependent from the position, spatial orientation and/or type of an intervention tool which is introduced into the patient.

Abstract: A system for dispensing and verifying a dosage in a bottle. The system includes a stage for holding the bottle. The system further includes a pump-printer module, configured to receive a set of dosage specifications. The module includes a dosage dispenser configured to fill the bottle with the dosage according to the set of dosage specifications, and a printer device configured to print and apply a label onto the bottle listing out the set of dosage specifications. The dosage dispenser and the printer device are configured to operate simultaneously. The system further includes one or more imaging components disposed optically in-line with the stage, configured to capture a plurality of images of the bottle and the label.

Abstract: A method for remotely approving and dispensing medications directly to a patient for opioid addiction treatment. The method includes determining an identity of the patient, by a biometric sensing component and establishing remote communication between the patient and a medical official certified for treating opioid addiction. The method also includes transmitting a medical record corresponding to the patient to the medical official, generating, by the medical official, the opioid addiction treatment, generating an event record made up of the identity of the patient, the opioid addiction treatment, the medical record, and the medical official, and transmitting the event record to a dosing location.

Abstract: A device for automated pumping and dispensing of single doses of opioid addiction medication to a user. The device includes a pumping platform, an outlet, and a cup dispensing component configured to dispense a cup onto the pumping platform. The device further includes a pumping mechanism configured to rotate and pump the opioid addiction medication into the cup. The device further includes a pusher wheel operatively coupled to the pumping platform, configured to cyclically rotate between positions. In one position, the pusher wheel pushes the pumping mechanism away and blocks the outlet. In another position, the pusher wheel moves such that the pumping mechanism rotates over the pumping platform and blocks the outlet. In another position, the pusher wheel pushes the cup from the pumping platform to the outlet and moves such that the outlet is exposed.

Abstract: Systems, apparatuses, and methods for placing cells in an integrated circuit are described. In various embodiments, an integrated circuit is divided into many partitions. In a first set of partitions susceptible to transistor latch-up, the many transistor gate stripes are connected to one of the power rails rather than left floating. The lengths of the transistor gate stripes are shortened for well tap cells in the first partition, but increased in a second partition susceptible for poor signal integrity. One or more implant layers are formed underneath the transistor gate stripes in each of the first and second partitions to adjust an amount of protection against transistor latch-up and poor signal integrity. An electrostatic discharge transistor is included with at least one source region of multiple source regions formed in a well with a same doping polarity as the at least one source region.

Abstract: The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

Abstract: The invention relates to a rigid, curved laryngoscope. The laryngoscope is characterised in that it has a rigid, curved body, a light source and image-capturing unit integrated in the body and two channels, each suitable for accommodating a flexible surgical instrument, which is suited for a mechanical intervention at the operation site. The laryngoscope according to the invention can be simply and economically produced and is suited for repeated use. It is also mechanically stable and can be handled quickly and easily.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer, in particular of oropharyngeal squamous cell carcinoma (OPSCC). The present invention furthermore relates to tumor-associated T-cell peptide epitopes that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A system, method and apparatus for configuring a node in a sensor network. A sensor service can enable sensor applications to customize the collection and processing of sensor data from a monitoring location. In one embodiment, sensor applications can customize the operation of nodes in the sensor network via a sensor data control system.

Abstract: The present disclosure is directed to embodiments of a kiosk including a chassis having a patient compartment and a medication compartment. A patient does not have access to the medication compartment in the patient compartment. A dispense structure extends from the patient compartment to the medication compartment such that a dosage of medication may be dispensed to the patient when within the patient compartment. After the medication is dispensed to the patient, a medical professional observes the patient ingest the medication through a video conference display within the patient compartment. A biometric scanner may be in electrical communication with a lock in mechanical cooperation with a door hingedly coupled to the chassis to limit access to the medication compartment. An insulated safe with an internal chamber wherein the internal chamber's temperature is regulated.

Abstract: In an embodiment, an integrated circuit includes transistors in different active regions, electrically isolated using single diffusion break isolation. The single diffusion break isolation includes a first dummy transistor that has a different threshold voltage than the transistors in either active region for which the single diffusion break is creating isolation. The first dummy transistor may have lower leakage current than transistors in either active region, creating effective isolation between the active regions and consuming relatively small amounts of power due to the lower leakage currents.

Abstract: The invention provides a method of suppressing gene expression, comprising providing a mammalian cell with a suppression target RNA molecule comprising a heterologous RNAi target site operatively linked to a RNA sequence from a gene of interest, or with a DNA encoding said suppression target RNA molecule; providing to the cell an inhibitory RNA that has a complementary nucleotide sequence to the heterologous RNAi target site; wherein binding of the inhibitory RNA to the heterologous RNAi target site suppresses gene expression of the operatively linked RNA sequence from the gene of interest; and wherein said heterologous RNAi target site has a size of at least 18 nucleotides in length. The invention further provides nucleic acids and cells suitable for such a method.

Abstract: The invention relates to a method for determining an X-ray image dataset of a target region of an object to be examined, wherein projection images showing the target region are captured by means of an X-ray detector and the X-ray image dataset is reconstructed from the projection images, wherein a first portion of the projection images is captured so as to be collimated onto the target region by the target region being irradiated with X-ray radiation by means of an X-ray device through at least one main radiation opening of a collimator assembly. The invention also relates to a corresponding apparatus for determining an X-ray image dataset of a target region of the object to be examined. The invention generally relates to the field of medical X-ray imaging, in particular with the aim of acquiring projections for reconstructing 2D computed-tomography images.

Abstract: Multi-die structures and methods of fabrication are described. In an embodiment, a multi-die structure includes a first die, a second die, and die-to-die routing connecting the first die to the second die. The die-to-die interconnection may be monolithically integrated as a chip-level die-to-die routing, or external package-level die-to-die routing.

Abstract: A system, method and apparatus for integrated building operations management. Nodes in the sensor network can be configured to interface with a building control system to exchange sensor-related information.