Patent number: 6509365
Abstract: 2-Phenylbenzimidazoles and 2-phenylindoles of formula I
wherein
A is N or CH,
R1 is hydrogen or alkyl which optionally carries an OR11 group,
R11 is hydrogen or alkyl,
R2 is hydrogen, chlorine, fluorine, bromine, iodine, alkyl, nitro, CF3, CN, NR21R22, NH—CO—R23, OR21,
R21 and R22 are each hydrogen or alkyl,
R23 is hydrogen, alkyl or phenyl,
R3 is —(CH2)q—NR31R32,
q is 0, 1, 2 or 3,
R31 is hydrogen, alkyl, (CH2)rNR33R34,
R32 is (CH2)rNR33R34,
r is 2, 3, 4, 5 or 6,
R33 and R34 are each hydrogen, alkyl or phenylalkyl wherein the phenyl ring is optionally substituted, or
R33 and R34 and the nitrogen atom form a 3- to 8-membered ring,
R4 is hydrogen, alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH—CO—R43, OR41,
R41 and R42 are each hydrogen or alkyl, and
R43 is alkyl or phenyl,
are useful as inhibitors of poly(ADP-ribose)polymerase and for the production of drugs.
Type:
Grant
Filed:
May 17, 2001
Date of Patent:
January 21, 2003
Assignee:
BASF Aktiengesellschaft
Inventors:
Wilfried Lubisch, Michael Kock, Thomas Höger