Patents by Inventor Thomas Hoock

Thomas Hoock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell-based kinase assay
    Publication number: 20060141549
    Abstract: The present invention relates to improved systems and strategies for the investigation of kinase activity in cells. More specifically, cell-based assay methods are provided that allow the phosphorylating activity of a kinase to be determined inside a cell. The invention also provides cell-based screening assays for identifying compounds that have the ability to modulate the phosphorylating activity of protein kinases. Modulators of kinase activity identified by the screening methods are also described, as are pharmaceutical compositions comprising these modulators and methods of using them for inhibiting or enhancing cellular responses triggered by kinase-mediated events.
    Type: Application
    Filed: August 2, 2005
    Publication date: June 29, 2006
    Inventors: Sudipta Mahajan, Thomas Hoock
  • Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
    Publication number: 20030083467
    Abstract: The present invention relates to novel fusion proteins, DNA molecules encoding the same, vectors comprising the DNA molecules, and host cells containing the vectors for use in measuring protease activity using a novel transcriptional assay. This invention also relates to a method for determining the inhibitory activity of a compound against a protease and to a method for comparing the activity of two proteases which recognize the same cleavage site. Kits for assaying protease activity comprising DNA molecules encoding the fusion protein substrates of this invention are also contemplated.
    Type: Application
    Filed: November 20, 2002
    Publication date: May 1, 2003
    Inventors: Ursula Germann, Thomas Hoock, Ann Kwong
  • Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
    Patent number: 6528276
    Abstract: The present invention relates to novel fusion proteins, DNA molecules encoding the same, vectors comprising the DNA molecules, and host cells containing the vectors for use in measuring protease activity using a novel transcriptional assay. This invention also relates to a method for determining the inhibitory activity of a compound against a protease and to a method for comparing the activity of two proteases which recognize the same cleavage site. Kits for assaying protease activity comprising DNA molecules encoding the fusion protein substrates of this invention are also contemplated.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: March 4, 2003
    Assignee: Vertex Pharmaceuticals Inc.
    Inventors: Ursula Germann, Thomas Hoock, Ann Kwong
  • Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
    Patent number: 6117639
    Abstract: The present invention relates to novel fusion proteins, DNA molecules encoding the same, vectors comprising the DNA molecules, and host cells containing the vectors for use in measuring protease activity using a novel transcriptional assay. This invention also relates to a method for determining the inhibitory activity of a compound against a protease and to a method for comparing the activity of two proteases which recognize the same cleavage site. Kits for assaying protease activity comprising DNA molecules encoding the fusion protein substrates of this invention are also contemplated.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: September 12, 2000
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Ursula Germann, Thomas Hoock, Ann Kwong