Abstract: A rotary component for a gas turbine engine includes a plurality of rotor blades operably coupled to a rotating shaft extending along the central axis and an outer casing arranged exterior to the plurality of rotor blades in a radial direction of the gas turbine engine. The outer casing defines a gap between a blade tip of each of the plurality of rotor blades and the outer casing. The outer casing includes a plurality of features formed into an interior surface thereof. Each of the plurality of features includes one or more design parameters that are perturbed about a mean design parameter for stall performance so as to provide a circumferential variation in wake strengths associated with the plurality of rotor blades, thereby reducing operational noise of the gas turbine engine.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: A connector is provided to attach a supported member to a supporting member, with the supported member being in sloped and skewed relation to the supporting member. The connector has back members attached to side members. A seat member attaches to the side members through a hinged connection. The seat member interfaces with the bottom face of the supported member and can be disposed at a sloped angle. A pair of seat side members extend from the seat member.

Abstract: Embodiments herein relate to a local assistant system responding to voice input using an ear-wearable device. The system detects a wake-up signal and receives a first voice input communicating a first query content. The system includes speech recognition circuitry to determine the first query content, speech generation circuitry, and an input database of locally-handled user inputs. If the first audio input matches one of the locally-handled user inputs, then the system takes a local responsive action. If the first audio input does not match one of the locally-handled user inputs, then the system transmits at least a portion of the first query content over a wireless network to a network resource.

Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: An image-reading device, such as optical code readers used in retail environments to scan objects, is configured to select from various operational modes. The operational modes are selected based on an application of the image-reading device, such as optical code identification or image recognition. Red, white, and other color light sources are activated in patterns corresponding to an illumination sequence of the selected operational mode, while imagers are activated to capture an image based on an exposure pattern of the selected operational mode. Further, a repeating series of light pulses having different portions of light is provided. Various imagers are configured to capture images over one of the portions. This allows an operator to perceive one continuous light pattern, yet allows various imagers to capture an image under different light conditions used for different applications of the image-reading device.

Abstract: Provided are compounds of Formula (I?): or pharmaceutically acceptable salts thereof, wherein the variables in the formula are as defined herein; and methods for their use and production.

Abstract: Disclosed herein, among other things, are methods and apparatus for own-voice sensing in hearing assistance devices. One aspect of the present subject matter includes an in-the-ear (ITE) hearing assistance device adapted to process sounds, including sounds from a wearer's mouth. According to various embodiments, the device includes a hollow plastic housing adapted to be worn in the ear of the wearer and a differential sensor mounted to an interior surface of the housing in an ear canal of the wearer. The differential sensor includes inlets located within the housing and the differential sensor is configured to improve speech intelligibility of sounds from the wearer's mouth, in various embodiments.

Abstract: A radioisotope generator including a laser, a volume of target isotope, and nanoparticles in a solid, liquid, or gas state is provided. In at least one aspect, the radioisotope generator accelerates the decay rate of an isotope, with the laser being used to accelerate the decay of the isotope for the production of desired product isotopes.

Abstract: An approach is disclosed for running a first smart contract on a first blockchain platform which restricts access to a client's funds appropriated to a second smart contract running on a second blockchain platform. A transaction is received by invoking the first smart contract authorizing the second smart contract. In response to receiving an indication of a successful completion of the first smart contract, a plurality of client's authorization tickets are sent to the second smart contract which restricts access to the client's funds appropriated to the second smart contract running on the second blockchain platform. The invoked smart contract receives the set of authorization information and records the set of authorization information. After receiving a set of authenticated authorization tickets exceeding a predetermined threshold, the funds are atomically eliminated on the first blockchain platform and a converted funds generated on the second blockchain platform.

Abstract: Methods of manufacturing an orthopedic shoulder device is provided. The method includes providing a cradle device configured to receive and support a portion of an arm of a user. The method includes assembling an abduction positioning device by coupling the cradle device to an apex of a flexible arch utilizing a rotation coupling member such that adjusting an amount of curvature of the flexible arch adjusts an angle of abduction of the arm of the user relative to a torso of the user. The method includes providing at least one strap for coupling between at least two locations on the flexible arch such that the amount of curvature of the flexible arch is adjusted by adjusting an amount of the at least one strap coupled between the at least two locations on the flexible arch. Methods of utilizing such an orthopedic shoulder device are also provided.

Abstract: Embodiments herein relate to a local assistant system responding to voice input using an ear-wearable device. The system detects a wake-up signal and receives a first voice input communicating a first query content. The system includes speech recognition circuitry to determine the first query content, speech generation circuitry, and an input database of locally-handled user inputs. If the first audio input matches one of the locally-handled user inputs, then the system takes a local responsive action. If the first audio input does not match one of the locally-handled user inputs, then the system transmits at least a portion of the first query content over a wireless network to a network resource.

Abstract: Disclosed herein, among other things, are methods and apparatus for own-voice sensing in hearing assistance devices. One aspect of the present subject matter includes an in-the-ear (ITE) hearing assistance device adapted to process sounds, including sounds from a wearer's mouth. According to various embodiments, the device includes a hollow plastic housing adapted to be worn in the ear of the wearer and a differential sensor mounted to an interior surface of the housing in an ear canal of the wearer. The differential sensor includes inlets located within the housing and the differential sensor is configured to improve speech intelligibility of sounds from the wearer's mouth, in various embodiments.

Abstract: An image-reading device, such as optical code readers used in retail environments to scan objects, is configured to select from various operational modes. The operational modes are selected based on an application of the image-reading device, such as optical code identification or image recognition. Red, white, and other color light sources are activated in patterns corresponding to an illumination sequence of the selected operational mode, while imagers are activated to capture an image based on an exposure pattern of the selected operational mode. Further, a repeating series of light pulses having different portions of light is provided. Various imagers are configured to capture images over one of the portions. This allows an operator to perceive one continuous light pattern, yet allows various imagers to capture an image under different light conditions used for different applications of the image-reading device.