Abstract: Provided is a method of detecting analytes in a cell or tissue sample, the method comprising: a) introducing into the cell or tissue sample at least one tagging moiety, wherein the tagging moieties can interact with specific proteins of interest; b) detecting analytes and tagging moieties in the cell or tissue sample; c) spatially detecting proteins in the cell or tissue sample; and d) constructing a map of the analytes in the cell or tissue sample based on the data from steps b) and c). Also provided is a microfluidic chip using the method of detecting analytes, and methods of monitoring an in situ model of a tumor, methods of detecting cancer, and methods of determining response of a subject to a treatment protocol using the microfluidic chip.

Abstract: Disclosed herein are methods of detecting multiple protein interactions within a cell or tissue sample. This can be done by multiplexed imaging. Also disclosed are systems and kits for carrying this out.

Abstract: A novel method is disclosed to make cellulose filaments (CF) from wood or other plant fibers with lower energy consumption. The method consists of multi-stage, high consistency refining, followed by low consistency refining or by low consistency, non-refining mechanical treatment, of wood or other plant fibers. The total specific refining energy for the multi-stage, high consistency refining is preferably 2,000-18,000 kWh/t, and more preferably 2,000-12,000 kWh/t. The CF produced can be used as a superior reinforcement additive in the production of paper, tissue or paperboard and in the production of plastic composites. It can also be used as a viscosity or rheology modifier in food products, coatings or drilling muds. The CF produced can also be used to make strong films for application in packaging and in composites.

Abstract: A novel method is disclosed to make cellulose filaments (CF) from wood or other plant fibers with lower energy consumption. The method consists of multi-stage, high consistency refining, followed by low consistency refining or by low consistency, non-refining mechanical treatment, of wood or other plant fibers. The total specific refining energy for the multi-stage, high consistency refining is preferably 2,000-18,000 kWh/t, and more preferably 2,000-12,000 kWh/t. The CF produced can be used as a superior reinforcement additive in the production of paper, tissue or paperboard and in the production of plastic composites. It can also be used as a viscosity or rheology modifier in food products, coatings or drilling muds. The CF produced can also be used to make strong films for application in packaging and in composites.

Abstract: A novel method for the production of light-stable and process-stable lignocellulosic materials, in particular, the production of mechanical wood pulps with much improved light and process stability is described, as well as the resulting pulps of improved light and process stability and papers containing such pulps. The novel method involves the reaction of lignocellulosic materials such as bleached chemithermomechanical pulps (BCTMP) with (a) a water-soluble, fibre-reactive yellowing inhibitor possessing two or more secondary amino or ammonium (—NHR? or —HN+HR?), tertiary amino or ammonium (—NR?R? or —HN+R?R?), and/or quaternary ammonium (—N+R?R?R??) functional groups in an aqueous medium, or (b) a water-soluble, fibre-reactive hindered amine light stabilizer possessing said amino or ammonium functional groups in an alkaline peroxide bleaching medium or in an aqueous medium with a subsequent bleaching of the materials in an alkaline peroxide bleaching medium.

Abstract: Oxidized white liquor is heat treated to increase the concentration of polysulphide measured at 285 or 286 nm (PSUV) or measured at 416 nm (PSVIS) and the PSUV/PSGR or PSVIS/PSGR ratio, whereby the content of active polysulphide in the total polysulphide is increased which active polysulphide can be exploited to increase pulp yield in Kraft pulping.