Abstract: A device (1) for crimping connection elements (2). The device (1) comprises a machine frame (5), at least one punch, a drive assembly, at least one anvil (17), and a working chamber (31). The punch (3) is preferably arranged in a movable manner in relation to the machine frame (5). The punch (3) contains at least one working surface (4) for deforming a connection element (2). The drive assembly for moving the punch (3) is connected to the punch. The anvil (17) is connected to the machine frame (5) and has a receiving surface (8) for the connection element (2). The working chamber is located between the punch and the anvil and is opened and closed by a relative movement between the punch and the anvil. The device has at least one sonotrode, by which the receiving surface (8) of the anvil (17) is supplied with ultrasound.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?) which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?) which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: A sonotrode (18) for producing a welded and/or soldered join between a cable (17) and a sheath (17), covering the cable (17), comprising at least one working surface (2). The working surface (2) is curved in a concave manner, at least in sections. An anvil (10) comprises at least one counter surface (11) which is curved in a concave manner, at least in sections. The device for producing the join between a cable (17) and a sheath (17), covering the cable (17), comprises a sonotrode (18) joined to an ultrasound source (8) at least at a joining surface (5), and comprising an anvil (10) arranged opposite the working surface (2) of the sonotrode (18). A method for producing a join between a cable (17) and a sheath (17) covering the cable (17) is also disclosed.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?), which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: A device (1) for crimping connection elements (2). The device (1) comprises a machine frame (5), at least one punch, a drive assembly, at least one anvil (17), and a working chamber (31). The punch (3) is preferably arranged in a movable manner in relation to the machine frame (5). The punch (3) contains at least one working surface (4) for deforming a connection element (2). The drive assembly for moving the punch (3) is connected to the punch. The anvil (17) is connected to the machine frame (5) and has a receiving surface (8) for the connection element (2). The working chamber is located between the punch and the anvil and is opened and closed by a relative movement between the punch and the anvil. The device has at least one sonotrode, by which the receiving surface (8) of the anvil (17) is supplied with ultrasound.

Abstract: A sonotrode (18) for producing a welded and/or soldered join between a cable (17) and a sheath (17), covering the cable (17), comprising at least one working surface (2). The working surface (2) is curved in a concave manner, at least in sections. An anvil (10) comprises at least one counter surface (11) which is curved in a concave manner, at least in sections. The device for producing the join between a cable (17) and a sheath (17), covering the cable (17), comprises a sonotrode (18) joined to an ultrasound source (8) at least at a joining surface (5), and comprising an anvil (10) arranged opposite the working surface (2) of the sonotrode (18). A method for producing a join between a cable (17) and a sheath (17) covering the cable (17) is also disclosed.

Abstract: A device (10?) for welding components by ultrasound. The device (10?) comprises a sonotrode (11?) having a sonotrode head (12?), which can be excited by a vibration generator to produce torsion vibrations with respect to a torsion axis (T). At least one welding surface (14?) is arranged on the peripheral side on the sonotrode head (12?) with respect to the torsion axis (T). The device (10?) also comprises a support device (15?) which supports the sonotrode head (11?) in a support area (16?), which contains a vibration node of the sonotrode head (12?). The support area (16?) and the welding surface (14?) at least partially extend along a common plane (E) which extends perpendicular to the torsion axis (T). A device (10?) for welding components by ultrasound by using a temperature control device are also disclosed.

Abstract: The invention relates to a protein or peptide comprising the C?-D loop of a member of the CD28 family, uses thereof and mAbs obtainable therefrom.

Abstract: The invention relates to the use of a CD28-specific superagonistic monoclonal antibody (mAb) or of a mimicry compound hereto for making a pharmaceutical composition for the induction and/or multiplication of regulatory T cells.

Abstract: The invention relates to the use of a CD28-specific superagonistic monoclonal antibody (mAb) or of a mimicry compound hereto for making a pharmaceutical composition for the induction and/or multiplication of regulatory T cells.

Abstract: The invention teaches human-compatible monoclonal antibodies which are specific against human CD28 and human T-lymphocytes of several to all subgroups to activate without occupancy of an antigen receptor of the human T-lymphocytes and thus antigen-non-specifically.

Abstract: The invention teaches a method for testing a prospective or known immunomodulatory drug for T-cell activation, comprising the step of contacting in-vitro a peripheral blood mononuclear cell (PBMC) culture with a predetermined amount of the prospective or known immunomodulatory drug and observing the PBMC culture for T-cell activation using a readout system, upon contact with the prospective or known immunomodulatory drug, wherein the cell density of a PBMC preculture is adjusted such that cell-cell contact of the PBMC is enabled and wherein the PBMC preculture is cultured for at least 12 h.

Abstract: The invention relates to a protein or peptide comprising the C?-D loop of a member of the CD28 family, uses thereof and mAbs obtainable therefrom.

Abstract: The invention teaches human-compatible monoclonal antibodies which are specific against human CD28 and human T-lymphocytes of several to all subgroups to activate without occupancy of an antigen receptor of the human T-lymphocytes and thus antigen-non-specifically.

Abstract: The invention relates to microparticles with a support structure and CD28-specific superagonistic monoclonal antibodies (mAbs) bonded to the support structure or a compound mimicking the above.

Abstract: The invention relates to the use of a CD28-specific superagonistic monoclonal antibody (mAb) or of a mimicry compound hereto for making a pharmaceutical composition for the induction and/or multiplication of regulatory T cells.

Abstract: The invention relates to the use of a CD28-specific superagonistic monoclonal antibody (mAb) or of a mimicry compound hereto for making a pharmaceutical composition for the induction and/or multiplication of regulatory T cells.

Abstract: The invention relates to a protein or peptide comprising the C?-D loop of a member of the CD28 family, uses thereof and mAbs obtainable therefrom.

Abstract: The invention relates to microparticles with a support structure and CD28-specific superagonistic monoclonal antibodies (mAbs) bonded to the support structure or a compound mimicking the above.