Abstract: A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2 and R3 are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: Service cells may be utilized to limit the blast radius and reduce the probability of operational incidents (e.g., attacks, load spikes, distributed thrash, and the like). Techniques discussed herein provide any suitable number of service cells, each if which include a management plane and a data plane. A work request that includes an intended state of the service cell can be received and stored. One or more execution tasks can be executed by a management plane of the service cell to bring the data plane to a state corresponding to the intended state. The management plane can monitor the actual state of the data plane with respect to the intended state (e.g., the state requested by a user). Over time, the management plane can make modifications to the service cell to ensure the resources of the data plane are ever in conformance with the intended state requested by the user.

Abstract: Techniques discussed herein manage backups of a service cell (SC). Each SC may include a data plane that is isolated from other SCs and comprises a distributed computing cluster (a cluster). A manifest that specifies one or more backup policies may be used to generate a full backup or a partial backup of a data set stored by the cluster. In accordance with the manifest, a signal may be sent to nodes of the cluster. In response, the nodes may transmit locally-stored data (e.g., data segments) to specified locations at a remote storage. The system may maintain a mapping of which segments correspond to data that was stored in the cluster at a time corresponding to a full or partial backup.

Abstract: Techniques discussed herein manage backups of a service cell (SC). Each SC may include a data plane that is isolated from other SCs and comprises a distributed computing cluster (a cluster). A manifest that specifies one or more backup policies may be used to generate a full backup or a partial backup of a data set stored by the cluster. In accordance with the manifest, a signal may be sent to nodes of the cluster. In response, the nodes may transmit locally-stored data (e.g., data segments) to specified locations at a remote storage. The system may maintain a mapping of which segments correspond to data that was stored in the cluster at a time corresponding to a full or partial backup.

Abstract: Techniques discussed herein manage backups of a service cell (SC). Each SC may include a data plane that is isolated from other SCs and comprises a distributed computing cluster (a cluster). A manifest that specifies one or more backup policies may be used to generate a full backup or a partial backup of a data set stored by the cluster. In accordance with the manifest, a signal may be sent to nodes of the cluster. In response, the nodes may transmit locally-stored data (e.g., data segments) to specified locations at a remote storage. The system may maintain a mapping of which segments correspond to data that was stored in the cluster at a time corresponding to a full or partial backup.

Abstract: Service cells may be utilized to limit the blast radius and reduce the probability of operational incidents (e.g., attacks, load spikes, distributed thrash, and the like). Techniques discussed herein provide any suitable number of service cells, each if which include a management plane and a data plane. A work request that includes an intended state of the service cell can be received and stored. One or more execution tasks can be executed by a management plane of the service cell to bring the data plane to a state corresponding to the intended state. The management plane can monitor the actual state of the data plane with respect to the intended state (e.g., the state requested by a user). Over time, the management plane can make modifications to the service cell to ensure the resources of the data plane are ever in conformance with the intended state requested by the user.

Abstract: This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a thiopyrimidinone structure which function as inhibitors of ALDH protein, and their use as therapeutics for the treatment of cancer and other diseases.

Abstract: A lubrication bypass system is disclosed for controlling flow of a lubricant to a reciprocating machine, such as two-stroke engines and two-stroke compressors, based upon one or more operating parameters. The lubrication bypass system can be positioned in fluid communication with a lubrication system that transports a primary flow of the lubricant from a lubricant reservoir to the reciprocating machine cylinder at a predetermined primary flow rate. The lubrication bypass system can be configured to divert a portion of the primary flow, a bypass flow, from the lubrication system at a bypass flow rate based upon the operating parameters. As a result, a secondary flow of lubricant remaining within the lubrication system can be supplied to the reciprocating machine at a secondary flow rate that is less than the primary flow rate. In this manner, the lubrication bypass system can regulate the secondary flow rate.

Abstract: A low emissions 2-stroke natural gas fueled engine includes at least one cylinder with an exhaust port in communication with a silencer/catalytic converter unit. The unit has first and second volumes in communication with each other. The first volume dampens spurious exhaust pressure excursions and removes particulates in the exhaust. The second volume houses an oxidation catalyst for treating exhaust to reduce exhaust emissions. The engine oil has at most 10 ppm zinc content to reduce metal poisons contained in the exhaust prior to contact with the oxidation catalyst. The engine oil preferably has a very low ash content to minimize sulfur combustion components in the exhaust to reduce masking of the oxidation catalyst. The first volume preferably has a pressure relief valve set to relieve at a pressure greater than the maximum normal operating pressure of the engine to avoid excessive pressure excursions of the engine exhaust from damaging the oxidation catalyst.

Abstract: A low emissions 2-stroke natural gas fueled engine includes at least one cylinder with an exhaust port in communication with a silencer/catalytic converter unit. The unit has first and second volumes in communication with each other. The first volume dampens spurious exhaust pressure excursions and removes particulates in the exhaust. The second volume houses an oxidation catalyst for treating exhaust to reduce exhaust emissions. The engine oil has at most 10 ppm zinc content to reduce metal poisons contained in the exhaust prior to contact with the oxidation catalyst. The engine oil preferably has a very low ash content to minimize sulfur combustion components in the exhaust to reduce masking of the oxidation catalyst. The first volume preferably has a pressure relief valve set to relieve at a pressure greater than the maximum normal operating pressure of the engine to avoid excessive pressure excursions of the engine exhaust from damaging the oxidation catalyst.

Abstract: A low emissions 2-stroke natural gas fueled engine includes at least one cylinder with an exhaust port in communication with a silencer/catalytic converter unit. The unit has first and second volumes in communication with each other. The first volume dampens spurious exhaust pressure excursions and removes particulates in the exhaust. The second volume houses an oxidation catalyst for treating exhaust to reduce exhaust emissions. The engine oil has at most 10 ppm zinc content to reduce metal poisons contained in the exhaust prior to contact with the oxidation catalyst. The engine oil preferably has a very low ash content to minimize sulfur combustion components in the exhaust to reduce masking of the oxidation catalyst. The first volume preferably has a pressure relief valve set to relieve at a pressure greater than the maximum normal operating pressure of the engine to avoid excessive pressure excursions of the engine exhaust from damaging the oxidation catalyst.

Abstract: A hydrocarbon adsorber and a thermoplastic resin combined and formed to a porous scavenger for insertion into the air intake system of a motor vehicle engine. The resulting porous scavenger adsorbs volatile hydrocarbon molecules from raw fuel remaining in the air intake when the engine is shut off. The adsorbed molecules are then stripped or purged from the scavenger and reintroduced into the air intake when the engine is next started.

Abstract: A system and method for processing thermal signature data is provided. The system provides a thermal signature data processor that analyzes one or more pixels to determine whether an aspect of an alarm-worthy event has occurred. In one embodiment, the system analyzes visual data with relation to the thermal signature data to determine whether an alarm-worthy event (e.g., intrusion) has occurred and subsequently generates an alarm to indicate an intrusion or alarm-worthy event.

Abstract: An additive to enhance the activity of an FCC catalyst containing zeolite and matrix components comprises zeolite microspheres having a novel morphology comprising a macroporous matrix and crystallized zeolite freely coating the walls of the pores of the matrix. The additives formed from microspheres containing a metakaolin and kaolin calcined through its exotherm, the latter calcined kaolin being derived from a kaolin having a high pore volume. Kaolin having a high pore volume can be a pulverized ultrafine kaolin or a kaolin which has been pulverized to have an incipient slurry point less than 57% solids.

Abstract: A combination of a container body, an opening in said container body, an inner wall on said container body, a basket, a plurality of fingers on said basket engaging said inner wall, and a sorbent body in said basket.

Abstract: A low emissions 2-stroke natural gas fueled engine includes at least one cylinder with an exhaust port in communication with a silencer/catalytic converter unit. The unit has first and second volumes in communication with each other. The first volume dampens spurious exhaust pressure excursions and removes particulates in the exhaust. The second volume houses an oxidation catalyst for treating exhaust to reduce exhaust emissions. The engine oil has at most 10 ppm zinc content to reduce metal poisons contained in the exhaust prior to contact with the oxidation catalyst. The engine oil preferably has a very low ash content to minimize sulfur combustion components in the exhaust to reduce masking of the oxidation catalyst. The first volume preferably has a pressure relief valve set to relieve at a pressure greater than the maximum normal operating pressure of the engine to avoid excessive pressure excursions of the engine exhaust from damaging the oxidation catalyst.

Abstract: A combination of a container and a sorbent wherein a support is provided in the neck of a container to support a sorbent out of contact with the contents of the container.

Abstract: An adsorbent capsule including a core of pressed adsorbent material having a water-insoluble binder, and a water-vapor or permeable coating of water-based resin, namely, hydroxypropylmethylcellulose.

Abstract: An additive to enhance the activity of an FCC catalyst containing zeolite and matrix components comprises zeolite microspheres having a novel morphology comprising a macroporous matrix and crystallized zeolite freely coating the walls of the pores of the matrix. The additives formed from microspheres containing a metakaolin and kaolin calcined through its exotherm, the latter calcined kaolin being derived from a kaolin having a high pore volume. Kaolin having a high pore volume can be a pulverized ultrafine kaolin or a kaolin which has been pulverized to have an incipient slurry point less than 57% solids.