Abstract: The present disclosure describes methods of administering N-acetylcysteine (NAC) via intranasal nose-to-brain administration. The effect of intranasal NAC nose-to-brain administration can be monitored using an analytical technique, for example, magnetic resonance spectroscopy (MRS). In some embodiments, intranasal nose-to-brain NAC can be used to treat a condition, for example, a brain injury.

Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.

Abstract: The present disclosure describes methods of administering a pharmaceutical composition comprising a glutathione precursor and a thermoresponsive polymer via intranasal administration. In some embodiments, intranasal administration of the glutathione precursor can be used to treat a condition, for example, a central nervous system disorder.

Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.

Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.

Abstract: The present disclosure describes methods of administering N-acetylcysteine (NAC) via intranasal nose-to-brain administration. The effect of intranasal NAC nose-to-brain administration can be monitored using an analytical technique, for example, magnetic resonance spectroscopy (MRS). In some embodiments, intranasal nose-to-brain NAC can be used to treat a condition, for example, a brain injury.

Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.

Abstract: The present disclosure describes methods of treating a central nervous system condition associated with oxidative stress using a 5-lipoxigenase activating protein (FLAP) inhibitor, for example, N-acetylcysteine or nordihydroguaiaretic acid. The present disclosure also describes methods of treating a central nervous system condition with N-acetylcysteine and a second therapeutic agent such as prostaglandin E2.

Abstract: Devices and methods for delivering a chemical compound to, through or into a membrane, tissue or layer are provided. The device may include an AC signal source and at least one electrode. In one application, an interdigitated electrode may be electrically connected to the AC signal source. In one application, the chemical compound such as a medicament containing a drug may be disposed on or within the electrode and logic may control the AC signal source to provide the signal, including setting or selecting characteristics such as voltage, frequency and the like to orient and/or motivate an amount of the chemical compound through the electrode and into the tissue.

Abstract: Devices and methods for delivering a chemical compound to, through or into a membrane, tissue or layer are provided. The device may include an AC signal source and at least one electrode. In one application, an interdigitated electrode may be electrically connected to the AC signal source. In one application, the chemical compound such as a medicament containing a drug may be disposed on or within the electrode and logic may control the AC signal source to provide the signal, including setting or selecting characteristics such as voltage, frequency and the like to orient and/or motivate an amount of the chemical compound through the electrode and into the tissue.

Abstract: A line light source includes point light source and a light distribution assembly for transporting light from the point source. A fluorescent colorant is included in the light distribution assembly.

Abstract: A portable system and method for printing variable information indicia on a reflective sign comprises providing a first polymeric sign component having a surface suitable for receiving a printed image. A definition of an image to be printed on the first sign component is provided to a portable computer. Indicia in the form of images is then rapidly transferred to the surface of the first sign component.

Abstract: An integrated retroreflective data communication display for visual and electromagnetic communication is described. The display may be configured as an integrated retroreflective electronic license plate, with printed visual information, similar to the information printed on traditional license plates, on retroreflective sheeting. An antenna network is integrated within the license plate for electromagnetic communication and may be connected to external electronic modules. The display may also be configured as an integrated retroreflective electronic road sign, also providing visual and electromagnetic information in a unitary structure.

Abstract: Retroreflective assembly comprising:a) a transparent globule having a first, uncoated part-spherical surface portion for reception of incident light; a second, substantially flat surface portion opposite the first surface portion; and a third, toroidal surface portion intermediate the first and second surface portions, the toroidal surface having a radius of curvature smaller than the radius of curvature of the first part-spherical surface portion;b) a monolayer of externally reflecting transparent microspheres for focusing and retroreflecting light beams incident upon the first surface portion and which have passed through, the globule, the monolayer being applied to the second surface portion and to at least a part of the toroidal surface portion; andc) a layer of diffuse reflecting pigment disposed behind the monolayer of microspheres.Optionally, a space coat is interposed between the monolayer and the diffuse reflecting pigment. In some embodiments, fluorescent pigment is used.

Abstract: An internally illuminated sign employs retroreflective sheeting with optically transmissive bonds between cover layer and base layer, thereby making the sign suitable for applications where visibility of the sign is required if the internal illumination source fails. A light conduit may be employed to allow the source of internal illumination to be remote from the interior of the sign enclosure. Total internal reflection type sheeting also may be employed to diffuse the internal illumination.

Abstract: A sheet having a set of axial markings viewable as a contour-dependent, directional image. The image is intact only when the sheet is in substantially a predetermined contour and viewed within a predetermined conical field of view. Also a method for forming such sheets.

Abstract: A sheet containing an integrated-directional, half-tone image. Each sheet may contain one or more such images. Also a method for forming such images in microlens sheetings comprising directly a highly collimated light through an interposed half-tone mask.

Abstract: A directional image is created in transparent sheeting comprising a monolayer of microlenses by forming deformations in at least some of the microlenses by irradiation with a laser beam which has a short pulse duration. The directional images may be formed in transparent sheeting which has been applied to a document as an overlay. When viewed under diffuse lighting conditions, the deformations appear as a dark image. The deformations may be formed so that when viewed under retroreflective conditions within a conical field the image is darker than the surrounding background, and when viewed under retroreflective conditions outside the conical field the image is brighter than the surrounding background.

Abstract: Retroreflective sheeting of the prior art comprises a monolayer of transparent glass microspheres partially embedded in a binder layer and a specularly reflective layer covering the back surfaces of the microspheres. In the prior art, a laser beam directed at an angle to the face of the sheeting forms an image in such sheeting which is directional in that it can be viewed only from that angle. In the invention, such a directional image is provided by tiny ellipsoidal cavities, each opening through a back surface of the microsphere.

Abstract: The novel transparent sheet contains at least one authenticating image, each image being viewable from the front of the sheet, but only across a cone which preferably is less than 90.degree.. The novel sheet may be adhesively bonded over information areas of a document for authenticating purposes. When such an authenticating image is viewable only from an angle appreciably different from angles at which the document is ordinarily viewed, the image is obscure in that users of the document will notice the authenticating image only when confirming the authenticity of the document. Usually each authenticating image is viewable only across a cone of about 10 to 20 degrees.