Abstract: A computer-implemented method for operating an approval manager for approving control unit functions of different safety levels in a control unit of a technical system. The method includes: carrying out diagnostic functions in the control unit, wherein a safety level is assigned to each of the diagnostic functions; depending on the detection of a fault event or a functionality by the relevant diagnostic function, adjusting an associated status variable in a status variable memory area assigned to the safety level of the diagnostic function; carrying out a control unit function, which is assigned to a particular safety level, depending on one or more associated status variables, wherein only status variables which are stored in status variable memory areas assigned to the safety level of the control unit function or higher safety levels are taken into account.

Abstract: The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric m

Abstract: The present invention relates to a method of identifying a predisposition for developing type 2 diabetes mellitus in a subject, said method comprising the step of assessing in a sample obtained from said subject the amount of one or more metabolite(s) selected from (a) a first group comprising the metabolites glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2, phosphatidylcholine acyl-alkyl C36:3 and isobaric metabolites having the same molecular mass as glycine, lysoPhosphatidylcholine acyl C18:2, lysoPhosphatidylcholine acyl C17:0, lysoPhosphatidylcholine acyl C18:0, lysoPhosphatidylcholine acyl C18:1, phosphatidylcholine acyl-alkyl C34:2, phosphatidylcholine acyl-alkyl C36:2 or phosphatidylcholine acyl-alkyl C36:3 but different chemical formula; and/or (b) a second group comprising the metabolite acetylcarnitine C2 and an isobaric m

Abstract: A method for operating a processing roller of a processing machine having a circumferential length and comprising a tool having a tool length extending in the circumferential direction is disclosed. A processing length extending in the circumferential direction is defined, along which the tool is engaged with the material to be processed during processing. A compensation length in the circumferential direction is further prescribed, along which a compensation motion of the processing roller is performed, wherein the tangential velocity of the processing roller is negative at least at times. The compensation length is determined using the circumferential length, the processing length, and the tool length.

Abstract: A method for operating a transverse machining roller of a transverse machining device, which is driven by means of a drive unit and is for the rotary machining of a product web that is transportable in a transport direction, in order to produce machined sections of product web of different formats, having the following steps: selection of a desired format for the sections of product web, preparation of a number of motion rules for controlling a rotary movement of the transverse machining roller in a control unit, for the desired format, production or calculation of a movement of the transverse machining roller on the basis of motion rules prepared in the control unit and/or at least one parameter of the drive unit and/or at least one instruction of a user.