Patents by Inventor Thomas Isaac
Thomas Isaac has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240150172Abstract: Disclosed herein are methods of producing a gas at a controlled rate, the methods comprising directing air through a layered bed to produce a gas. The layered bed comprises alternating layers of a layer of dry particles comprising a precursor and a layer of dry particles comprising a proton-generating species. The gas is produced at a rate that is controlled by controlling the presence or absence of air flowing though the layered bed, the amount of time the air flows through the layered bed, the total number of layers in the layered bed, the average thickness of each of the layers of dry particles comprising the precursor in the layered bed, the average thickness of each of the layers of dry particles comprising the proton-generating species in the layered bed, the temperature the method is performed at, or a combination thereof.Type: ApplicationFiled: January 9, 2024Publication date: May 9, 2024Inventors: William Ernst, Thomas Isaac
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Patent number: 11970038Abstract: Particular embodiments may enable configuring settings of a vehicle in a designated mode. A signal to perform a vehicle leveling process using an electronically controlled suspension of a vehicle may be received. A roll angle and a pitch angle of the vehicle as parked may be assessed based on data received from a position sensor built into the vehicle. Signals to adjust an electronically controlled suspension of the vehicle to reduce the roll angle or the pitch angle so that the vehicle is level as parked may be sent based on the assessed roll angle and pitch angle exceeding a threshold value. Data may be transmitted to present information related to the vehicle leveling process in a graphical user interface.Type: GrantFiled: October 14, 2022Date of Patent: April 30, 2024Assignee: Rivian IP Holdings, LLCInventors: Thomas Rocroi, Nathaniel Isaac Gallinger, Erik Robert Glaser, Jeffrey Park, Andrea Marie Best, Wassym Bensaid
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Patent number: 11912568Abstract: Disclosed herein are methods of producing a gas at a controlled rate, the methods comprising directing air through a layered bed to produce a gas. The layered bed comprises alternating layers of a layer of dry particles comprising a precursor and a layer of dry particles comprising a proton-generating species. The gas is produced at a rate that is controlled by controlling the presence or absence of air flowing though the layered bed, the amount of time the air flows through the layered bed, the total number of layers in the layered bed, the average thickness of each of the layers of dry particles comprising the precursor in the layered bed, the average thickness of each of the layers of dry particles comprising the proton-generating species in the layered bed, the temperature the method is performed at, or a combination thereof.Type: GrantFiled: March 14, 2019Date of Patent: February 27, 2024Assignee: ICA TriNova, LLCInventors: William Ernst, Thomas Isaac
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Publication number: 20230405595Abstract: A device for manipulating many hundreds or thousands of microdroplets into an array using EWOD or oEWOD is provided. The device comprises: i) a chip comprising a first region for receiving and manipulating microdroplets; a second region comprising the array and a plurality of electrowetting pathways leading to the array; ii) a microdroplet source configured to provide microdroplets of a predetermined target diameter; iii) a channel configured to provide fluid communication between the microdroplet source and the first region of the chip; and iv) a pressure source configured to move the microdroplets between the microdroplet source and the first region of the chip. The electrowetting pathways on the chip are centre to centre separated by at least double the predetermined target diameter of the microdroplets from the microdroplet source. Furthermore, the controller is configured to enable synchronous movement of the microdroplets in the electrowetting pathways by application of EWOD or oEWOD force.Type: ApplicationFiled: October 5, 2021Publication date: December 21, 2023Applicant: LIGHTCAST DISCOVERY LTDInventors: Evangelia-Nefeli ATHANASOPOULOU, James BUSH, Jasmin Kaur Chana CONTERIO, William DEACON, Richard Jeremy INGHAM, Thomas ISAAC, Ibrahim Saygin TOPKAYA, Andreas Michael WAEBER
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Publication number: 20230364616Abstract: An apparatus for manipulating one or more microdroplets into an array using EWOD or oEWOD is provided. The apparatus comprises: a) a chip for manipulating microdroplets comprising: i) a plurality of electrowetting pathways leading to the array; and ii) one or more waste electrowetting pathways leading to a waste outlet; b) a detector for detecting one or more microdroplets with a distinct characteristic, said detector configured to obtain a measured dataset relating to the distinct characteristic of the detected microdroplet; c) a storage module configured to store and maintain a stored dataset associated with the characteristic measured by the detector; and d) a controller configured to receive the stored dataset from the storage module and the obtained measured dataset to determine whether the measured dataset is associated with a desired or undesired characteristic.Type: ApplicationFiled: October 5, 2021Publication date: November 16, 2023Applicant: LIGHTCAST DISCOVERY LTDInventors: Evangelia-Nefeli ATHANASOPOULOU, James BUSH, William DEACON, Richard Jeremy INGHAM, Thomas ISAAC, Ibrahim Saygin TOPKAYA, Emma TALBOT
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Publication number: 20230053150Abstract: Disclosed herein are methods of producing a gas, the methods comprising dynamically mixing dry particles comprising a precursor and dry particles comprising a proton-generating species for an amount of time to produce the gas and wherein the gas is produced at a rate that is controlled by controlling the rate at which the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed.Type: ApplicationFiled: November 1, 2022Publication date: February 16, 2023Inventors: William Ernst, Thomas Isaac
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Patent number: 11518676Abstract: Disclosed herein are methods of producing a gas at a variable rate, the methods comprising dynamically mixing dry particles comprising a precursor and dry particles comprising a proton-generating species to produce a gas and wherein the gas is produced at a rate that is varied by varying the amount of time the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, the rate at which the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, or a combination thereof.Type: GrantFiled: November 25, 2020Date of Patent: December 6, 2022Assignee: ICA TriNova LLCInventors: William Ernst, Thomas Isaac
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Publication number: 20210147231Abstract: Disclosed herein are methods of producing a gas at a variable rate, the methods comprising dynamically mixing dry particles comprising a precursor and dry particles comprising a proton-generating species to produce a gas and wherein the gas is produced at a rate that is varied by varying the amount of time the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, the rate at which the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, or a combination thereof.Type: ApplicationFiled: November 25, 2020Publication date: May 20, 2021Inventors: William Ernst, Thomas Isaac
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Patent number: 10850981Abstract: Disclosed herein are methods of producing a gas at a variable rate, the methods comprising dynamically mixing dry particles comprising a precursor and dry particles comprising a proton-generating species to produce a gas and wherein the gas is produced at a rate that is varied by varying the amount of time the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, the rate at which the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, or a combination thereof.Type: GrantFiled: April 24, 2018Date of Patent: December 1, 2020Assignee: ICA TriNova, LLCInventors: William Ernst, Thomas Isaac
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Publication number: 20200277668Abstract: A first apparatus for sequencing a polynucleotide analyte is provided an apparatus for sequencing a polynucleotide analyte comprising: (a) a first zone for generating a flowing stream of single nucleotides by progressive pyrophosphorolysis of a molecule of the analyte attached to a particle and exposed to a flowing aqueous medium; (b) a second zone for generating a corresponding stream of aqueous droplets from the aqueous medium and the nucleotide stream and wherein at least some of the droplets contain a single nucleotide; and (c) a third zone for storing and/or for interrogating each droplet to reveal a property characteristic of the single nucleotide it may contain; wherein in that the first zone includes at least one chemically-modified substrate adapted to bind temporarily to a particle having at least two different regions adapted to bind respectively to the substrate and to the analyte.Type: ApplicationFiled: February 17, 2017Publication date: September 3, 2020Applicant: BASE4 INNOVATION LIMITEDInventors: Cameron Alexander FRAYLING, Thomas ISAAC, Maciej SOSNA
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Publication number: 20200034119Abstract: A method for translating user inputs into discretely functional styled standalone features includes receiving a feature selection associated with a front-end user interface element configured for a client-side application from a user device at a designer-developer application. For each feature of the feature selection, the method identifies a data exchange format of the feature and determines whether the feature selection indicates a change to the feature. When the feature selection indicates the change to the feature, the method maps the change to an appropriate web-development language based on the type of edit associated with the change and updates the data exchange format for the feature of the feature selection based on the change. The method also receives a request for the front-end user interface element and communicating the data exchange format for each feature associated with the front-end user interface element of the request.Type: ApplicationFiled: June 20, 2019Publication date: January 30, 2020Applicant: Frank, Inc.Inventors: Thomas Isaac McLaughlin, Karim Antoine Sabri
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Publication number: 20190284049Abstract: Disclosed herein are methods of producing a gas at a controlled rate, the methods comprising directing air through a layered bed to produce a gas. The layered bed comprises alternating layers of a layer of dry particles comprising a precursor and a layer of dry particles comprising a proton-generating species. The gas is produced at a rate that is controlled by controlling the presence or absence of air flowing though the layered bed, the amount of time the air flows through the layered bed, the total number of layers in the layered bed, the average thickness of each of the layers of dry particles comprising the precursor in the layered bed, the average thickness of each of the layers of dry particles comprising the proton-generating species in the layered bed, the temperature the method is performed at, or a combination thereof.Type: ApplicationFiled: March 14, 2019Publication date: September 19, 2019Inventors: William Ernst, Thomas Isaac
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Publication number: 20180305209Abstract: Disclosed herein are methods of producing a gas at a variable rate, the methods comprising dynamically mixing dry particles comprising a precursor and dry particles comprising a proton-generating species to produce a gas and wherein the gas is produced at a rate that is varied by varying the amount of time the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, the rate at which the dry particles comprising the precursor and the dry particles comprising the proton-generating species are dynamically mixed, or a combination thereof.Type: ApplicationFiled: April 24, 2018Publication date: October 25, 2018Inventors: William Ernst, Thomas Isaac
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Publication number: 20120093724Abstract: Various embodiments of this invention relate generally to targeted activation and delivery of therapeutic drugs to cells that produce prostate specific antigen (PSA), prostate specific membrane antigen (PSMA) or human glandular kallikrein (hK2). Various further embodiments relate more specifically to PSMA-specific peptide prodrugs that become activated to yield therapeutic drugs. Further aspects of various embodiments of the present invention also relate to methods and compositions for treating or preventing cancers and methods and compositions for detecting and/or imaging cancers.Type: ApplicationFiled: March 17, 2010Publication date: April 19, 2012Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Samuel Ray Denmeade, John Thomas Isaacs, Soeren Brogger Christensen