Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

Abstract: For analyzing a sample containing particles of at least two categories, such as a sample containing blood cells, a particle counter subject to a detection limit is coupled with an analyzer capable of discerning particle number ratios, such as a visual analyzer, and a processor. A first category of particles can be present beyond detection range limits while a second category of particles is present within respective detection range limits. The concentration of the second category of particles is determined by the particle counter. A ratio of counts of the first category to the second category is determined on the analyzer. The concentration of particles in the first category is calculated on the processor based on the ratio and the count or concentration of particles in the second category.

Abstract: Holographic data storage media having a sandwiched construction are described in which a holographic recording material is sandwiched between two substrates. The holographic media formulation is often formed of two or more components mixed to obtain a homogeneous formulation. The holographic media formulation may include two or more components which are mixed together prior to injection between the substrates. Curing of the holographic media formulation is substantially avoided during mixing, yet accelerated after the formulation is injected between the substrates. Accordingly, the system and techniques can be used to improve the large scale manufacturability of such media by allowing for fabrication of such media within reasonable cycle times, such as less than one minute, while adhering to stringent requirements for optical clarity and parallelism.

Abstract: A hingeable and separable coupling device for coupling two objects together includes a first connectable member having a pair of holes, a shaft having an end which is slidably and biasedly extended through one of the holes of the first connectable member, a sleeve having a stub which is slidably and biasedly extended through another of the holes of the first connectable member, a pair of flanges one of which is mounted to the sleeve for the movement thereof and the other of which is mounted to the shaft for the movement thereof, a second connectable member having a pair of holes one for receiving the end of the shaft and another for receiving the stub of the sleeve, and a lever being pivotally attached to the first connectable member and having a pair of tapered projecting members for engaging and moving the flanges which in turn retracts the stub and the end of the shaft from the holes of the second connectable member and which uncouples the two connectable members.

Abstract: A quick release hinged support or bracket for coupling two cooperating objects together comprises a pair of plates each having opposed side walls and openings for mounting to the objects and further comprises retractable coupling members for hingedly coupling the two plates together. The retractable coupling members allows a user to quickly separate the plates of the hinged support and the two cooperating objects so that the user can conveniently and substantially clean the two objects such as a lid or cover attachable to a container or an appliance. The hinged support allows the user to quickly separate the two objects without having to use a tool.

Abstract: Disclosed herein is an optical vise used to securely fasten glasses thereto for performing maintenance functions, suitably constructed so that the glasses retained therein will not be marred or otherwise damaged while being repaired. The structure disclosed herein includes a pedestal providing a support for horizontally extending trays that serve to carry tools and parts, a vertically adjustable support structure which carries at its vertical extremity remote from the base and vise proper. The vise is capable of rotation about a horizontal axis and defines a nesting area for securing foam or a similar soft resilient rubber material which serves to constrain the eye glasses disposed in a slit between two such pads. A back portion of the vise is provided with a similarly spongy material provided with slits along one face thereof so that the arcuate portion of the glasses which when in use hook around the ears of the wearer slide within these slits to provide further support.