Patents by Inventor Thomas J. Albert

Thomas J. Albert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RET kinase inhibitors
    Patent number: 11970485
    Abstract: Disclosed herein are compounds of formula I: or a pharmaceutically acceptable salt thereof, where the variables are as defined herein. These compounds are useful in treating RET associated cancers. Formulations containing the compounds of formula I and methods of making the compounds of formula I are also disclosed.
    Type: Grant
    Filed: October 19, 2022
    Date of Patent: April 30, 2024
    Assignee: ELI LILLY AND COMPANY
    Inventors: Gabrielle R. Kolakowski, Erin D. Anderson, Steven W. Andrews, Christopher Pierre Albert Jean Boldron, Kevin R. Condroski, Thomas C. Irvin, Manoj Kumar, Elizabeth A. McFaddin, Megan L. McKenney, Johnathan Alexander McLean, Tiphaine Mouret, Michael J. Munchhof, Thomas Pierre Dino Pancaldi, Michael Alexander Pilkington-Miksa, Marta Pinto
  • USE OF MICROARRAYS FOR GENOMIC REPRESENTATION SELECTION
    Publication number: 20110184161
    Abstract: The present invention provides novel methods for reducing the complexity of a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented genomic nucleic acid. The disclosed method provides for cost-effective, flexible and rapid enrichment of target nucleic acid from complex biological samples.
    Type: Application
    Filed: April 11, 2011
    Publication date: July 28, 2011
    Inventor: THOMAS J. ALBERT
  • Method of performing PCR amplification on a microarray
    Patent number: 7892732
    Abstract: The present invention provides a method of amplifying target DNA by PCR or multiplex PCR on a microarray using array-immobilized DNA probes synthesized in a common area on the microarray by a maskless array synthesizer (MAS). The MAS constructed array-immobilized DNA probes include a universal primer linked to a sequence-specific probe, and optionally a calibrated probe for use in quantifying amplified target DNA.
    Type: Grant
    Filed: January 12, 2005
    Date of Patent: February 22, 2011
    Assignee: Roche Nimblegen, Inc.
    Inventors: Roland Green, Thomas J. Albert
  • System and method for improved processing of nucleic acids for production of sequencable libraries
    Publication number: 20110003701
    Abstract: An embodiment of an adaptor element for efficient target processing is described that comprises a semi-complementary double stranded nucleic acid adaptor comprising a non-complementary region and a complementary region, where the non-complementary region comprises a first amplification primer site and a second amplification primer site and the complementary region comprises a sequencing primer site and one or more inosine species.
    Type: Application
    Filed: February 23, 2009
    Publication date: January 6, 2011
    Inventors: Gianni Calogero Ferreri, Jan F. Simons, Michael Todd Ronan, Michael Egholm, Brian C. Godwin, David Roderick Riches, Stephen Kyle Hutchison, Michael S. Braverman, Melinda D. Palmer, Jeffrey Jeddeloh, Jacob Kitzman, Thomas J. Albert
  • ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS
    Publication number: 20100222232
    Abstract: The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules.
    Type: Application
    Filed: April 5, 2010
    Publication date: September 2, 2010
    Inventors: Thomas J. Albert, Roland Green, Todd Richmond, Michael Molla, Jeffrey Jeddeloh, Jason Patrick Affourtit, Mathreyan Srinivasan, Brian Christopher Godwin, Matthew Rodesch
  • Use of microarrays for genomic representation selection
    Publication number: 20080194413
    Abstract: The present invention provides novel methods for reducing the complexity of a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented genomic nucleic acid. The disclosed method provides for cost-effective, flexible and rapid enrichment of target nucleic acid from complex biological samples.
    Type: Application
    Filed: April 24, 2007
    Publication date: August 14, 2008
    Inventor: Thomas J. Albert
  • ENRICHMENT AND SEQUENCE ANALYSIS OF GENOMIC REGIONS
    Publication number: 20080194414
    Abstract: The present invention provides novel methods for reducing the complexity of preferably a genomic sample for further analysis such as direct DNA sequencing, resequencing or SNP calling. The methods use pre-selected immobilized oligonucleotide probes to capture target nucleic acid molecules from a sample containing denatured, fragmented (genomic) nucleic acids for reducing the genetic complexity of the original population of nucleic acid molecules.
    Type: Application
    Filed: January 8, 2008
    Publication date: August 14, 2008
    Inventors: Thomas J. Albert, Roland Green, Todd Richmond, Michael Molla, Jeffrey Jeddeloh, Jason Patrick Affourtit, Mathreyan Srinivasan, Brian Christopher Godwin, Matthew Rodesch