Abstract: A braking system for a vehicle is disclosed. The braking system may have a primary braking system (PBS) having a boost assist subsystem, and an electronic control unit (ECU) for controlling the PBS and the boost assist subsystem. A memory may be in communication with the ECU. A database may be stored in the memory and may define a plurality of category function codes. The codes may define what levels of braking operation may be provided by the PBS when one of a fault or an anomaly is detected. The ECU may further be configured to implement a brake boost evaluation software module to determine whether to apply a requested level of braking being requested by a subsystem of the vehicle when at least one of a malfunction or anomaly is present.

Abstract: A braking system for a vehicle is disclosed. The braking system may have a primary braking system (PBS) having a boost assist subsystem, and an electronic control unit (ECU) for controlling the PBS and the boost assist subsystem. A memory may be in communication with the ECU. A database may be stored in the memory and may define a plurality of category function codes. The codes may define what levels of braking operation may be provided by the PBS when one of a fault or an anomaly is detected. The ECU may further be configured to implement a brake boost evaluation software module to determine whether to apply a requested level of braking being requested by a subsystem of the vehicle when at least one of a malfunction or anomaly is present.

Abstract: This invention provides solar applications with a strong, light, universal solar panel mount that pivots inside the solar panel frame for compact storage or transport with no disassembly. It also pivots out at adjustable angles to work with any latitude or season without assembly. The mount is adjustable to a wide range of solar panel angles to allow the solar panel to best match the sun angle for multiple latitudes and seasons of the year. It can be temporarily free standing or permanently placed via the use of the attachment points.

Abstract: This invention provides solar applications with a strong, light, universal solar panel mount that pivots inside the solar panel frame for compact storage or transport with no disassembly. It also pivots out at adjustable angles to work with any latitude or season without assembly. The mount is adjustable to a wide range of solar panel angles to allow the solar panel to best match the sun angle for multiple latitudes and seasons of the year. It can be temporarily free standing or permanently placed via the use of the attachment points.

Abstract: This invention provides novel nucleotide constructs. Also provided are methods for making DNA constructs useful for introducing sequences into and disrupting the function of a gene in a cell, particularly an embryonic stem cell.

Abstract: The present invention is directed to methods and compositions useful in producing cells and animals having a disruption or modification of a target gene. Vectors useful in producing these cells and animals are described. In addition, methods of screening and enriching cells comprising a targeted gene modification are provided.

Abstract: This invention provides novel nucleotide constructs. Also provided are methods for making DNA constructs useful for introducing sequences into and disrupting the function of a gene in a cell, particularly an embryonic stem cell.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a DEZ receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an MGLUR5 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an n-CL4 cysteine protease gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to compositions and methods relating to the characterization and function of CCR6. Specifically, the present invention provides transgenic animals comprising disruptions in a CCR6 gene and methods of treating diseases conditions, such as pain, inflammatory bowel disease and rheumatoid arthritis. The present invention further relates to agents that modulate CCR6 and methods of screening for agents that modulate CCR6 for the treatment of diseases and conditions such as pain, inflammatory bowel disease and rheumatoid arthritis.

Abstract: The present invention relates to compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruption in a mGluR4. The present invention also provides methods of identifying agents that modulate mGluR4 expression and function, useful models, and potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to compositions and methods relating to the characterization and function of V1a vasopressin receptor. Specifically, the present invention provides transgenic animals comprising disruptions in a V1a vasopressin receptor gene and methods of treating diseases conditions, such as schizophrenia, diabetes and inflammatory bowel disease. The present invention further relates to agents that modulate V1a vasopressin receptor and methods of screening for agents that modulate V1a vasopressin receptor for the treatment of diseases and conditions such as schizophrenia, diabetes and inflammatory bowel disease.

Abstract: The present invention relates to compositions and methods relating to the characterization and function of the TRH receptor. Specifically, the present invention provides transgenic animals comprising disruptions in a TRH receptor gene and methods of treating diseases conditions, such as diabetes related disorders, anxiety, pain and epilepsy. The present invention further relates to agents that modulate the TRH receptor and methods of screening for agents that modulate TRH receptor for the treatment of diseases and conditions such as diabetes related disorders, anxiety, pain and epilepsy.

Abstract: The present invention is directed to methods and compositions useful in producing cells and animals having a disruption or modification of a target gene. Vectors useful in producing these cells and animals are described. In addition, methods of screening and enriching cells comprising a targeted gene modification are provided.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a 5-HT-2B gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a GPCR5-1 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an OGR1 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: This invention provides novel nucleotide constructs. Also provided are methods for making DNA constructs useful for introducing sequences into and disrupting the function of a gene in a cell, particularly an embryonic stem cell.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a platelet-activating factor receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.