Abstract: Disclosed are compounds suitable for enhancing cancer treatment, for example, a compound of formula (I): (I) wherein R1 is as defined herein. Also disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, a method of inducing apoptosis in cancer cells in a mammal, and a method of treating prostate cancer in mammal in need thereof comprising administration of a compound described herein.

Abstract: An input device includes a touch plate having a central axis and a top surface with three outer points evenly spaced away from the central axis. A touch sensor is used to detect a user touch on the top surface at the first outer point, and a support mechanism supports the touch plate and is configured to translate the touch plate at the second and third outer points upon application of the user touch and translation of the touch plate at the first outer point. Translation of the three outer points is substantially equal along the central axis.

Abstract: A highly-directed light, with color in the blue area of the spectrum, has been developed that meets the particular requirements of two types of users. One application enables a user to see a keyboard clearly enough, predominately from his peripheral vision, to use it while engaged in other principal tasks. The other application allows readers with aging eyesight to more clearly focus on written text without the aid of magnifying or reading glasses. The user's ocular physiology, the physics of the light source and the juxtaposition of the working components for the typical operational scenario were considered while designing an apparatus and method to deliver an optimal working solution.