Patents by Inventor Thomas J. Browne
Thomas J. Browne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11859447Abstract: A window covering system that includes an elongated tube configured for a window covering to be wound around the tube, a clutch assembly that includes a pulley and a power spring having a first end engaging the pulley and a second end that is stationary, a limiter assembly, a booster assembly arranged between the clutch assembly and the limiter assembly, a cord arranged at least partially within the clutch assembly, and a wand fixed to the cord to selectively raise and lower the window covering.Type: GrantFiled: May 11, 2017Date of Patent: January 2, 2024Assignee: ROLLEASE ACMEDA, INC.Inventors: Thomas J. Brown, II, Douglas Moore, Roccardo Santilli
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Patent number: 11096930Abstract: Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.Type: GrantFiled: April 24, 2017Date of Patent: August 24, 2021Assignees: Merck Sharp & Dohme Corp., IOmet Pharma Ltd.Inventors: Phillip M. Cowley, Meredeth Ann McGowan, Thomas J. Brown, Yongxin Han, Kun Liu, Qinglin Pu, Alan Wise, Hongjun Zhang, Hua Zhou
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Publication number: 20200230117Abstract: Disclosed herein are substituted imidazopyridine compounds of formula (I) which are inhibitors of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan-2,3-dioxygenase (TDO) enzymes: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO- and/or TDO-associated disease or disorder.Type: ApplicationFiled: April 24, 2017Publication date: July 23, 2020Applicants: IOMet Pharma Ltd., Merck Sharp & Dohme Corp.Inventors: Phillip M. Cowley, Meredeth Ann McGowan, Thomas J. Brown, Yongxin Han, Kun Liu, Qinglin Pu, Alan Wise, Hongjun Zhang, Hua Zhou
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Patent number: 10501458Abstract: Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the general formula (I) detailed within.Type: GrantFiled: July 1, 2016Date of Patent: December 10, 2019Assignees: Iomet Pharma Ltd., Merck Sharp & Dohme Corp.Inventors: Phillip M. Cowley, Alan Wise, Thomas J. Brown, Meredeth A. McGowan, Hua Zhou, Yongxin Han
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Publication number: 20190178030Abstract: A window covering system that includes an elongated tube configured for a window covering to be wound around the tube, a clutch assembly that includes a pulley and a power spring having a first end engaging the pulley and a second end that is stationary, a limiter assembly, a booster assembly arranged between the clutch assembly and the limiter assembly, a cord arranged at least partially within the clutch assembly, and a wand fixed to the cord to selectively raise and lower the window covering.Type: ApplicationFiled: May 11, 2017Publication date: June 13, 2019Applicant: ROLLEASE ACMEDA, INC.Inventors: Thomas J. BROWN, II, Douglas MOORE, Roccardo SANTILLI
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Publication number: 20180186787Abstract: Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the general formula (I) detailed within.Type: ApplicationFiled: July 1, 2016Publication date: July 5, 2018Applicants: Merck Sharp & Dohme Corp., IOmet Pharma ltd.Inventors: Phillip M. Cowley, Alan Wise, Thomas J. Brown, Meredeth A. McGowan, Hua Zhou, Yongxin Han
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Patent number: 9225795Abstract: Passive advertising via a video display unit or radio passive advertising is performed through the insertion of commercials at specific time locations based on signaling provided in a video or audio broadcast stream. However, such advertising systems do not take advantage of a recipient's first impulse to react to the advertisement, thereby losing a potential sale. Embodiments disclosed herein provide a recipient of a video display or radio broadcasts with real-time information on products (e.g., goods or services) placed in the video display or radio broadcasts. In addition, embodiments provide the recipient with a real-time opportunity to gather information or to respond to requests (e.g., marketing requests) at the time associated with the recipient's initial impulse to act in response to receiving the video display or radio broadcast.Type: GrantFiled: November 16, 2012Date of Patent: December 29, 2015Assignee: Rubriq CorporationInventors: Asghar D. Mostafa, Thomas J. Brown, Dyanna T. Gerber
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Patent number: 8497768Abstract: Disclosed is an antitheft, emergency system for a vehicle. The system may include a system activation switch, at least one emergency switch, an engine shutoff element connected to the engine, and an emergency transmitter. The at least one emergency switch may trigger the engine shutoff element to render the engine inoperational and may simultaneously, covertly trigger an emergency transmitter to transmit a distress signal.Type: GrantFiled: July 8, 2009Date of Patent: July 30, 2013Inventor: Thomas J. Brown
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Publication number: 20110006921Abstract: Disclosed is an antitheft, emergency system for a vehicle. The system may include a system activation switch, at least one emergency switch, an engine shutoff element connected to the engine, and an emergency transmitter. The at least one emergency switch may trigger the engine shutoff element to render the engine inoperational and may simultaneously, covertly trigger an emergency transmitter to transmit a distress signal.Type: ApplicationFiled: July 8, 2009Publication date: January 13, 2011Inventor: Thomas J. BROWN
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Patent number: 7832618Abstract: Disclosed are methodologies for producing lead type electrical components. Components are placed in a lead frame with termination paste applied to selected portions of the component. Upon firing of the assembled lead frame and electrical components, the electrical components are concurrently terminated, and provided with strongly secured leads.Type: GrantFiled: January 10, 2008Date of Patent: November 16, 2010Assignee: AVX CorporationInventors: John L. Galvagni, Thomas J. Brown
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Patent number: 7454827Abstract: A method for forming a threaded pedestal cup including providing a pedestal with an interior cavity having an inner surface, and a top portion that has a larger diameter than a bottom portion; inserting a non-threaded arbor into the interior cavity to engage the inner surface of the bottom portion; and engaging the outer surface with a threading tool, wherein the engaging includes deforming the metal into threads.Type: GrantFiled: November 2, 2004Date of Patent: November 25, 2008Assignee: Cap and Seal Company, Inc.Inventors: Thomas J. Brown, Gary T. Mayberry
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Publication number: 20080179382Abstract: Disclosed are methodologies for producing lead type electrical components. Components are placed in a lead frame with termination paste applied to selected portions of the component. Upon firing of the assembled lead frame and electrical components, the electrical components are concurrently terminated, and provided with strongly secured leads.Type: ApplicationFiled: January 10, 2008Publication date: July 31, 2008Applicant: AVX CorporationInventors: John L. Galvagni, Thomas J. Brown
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Publication number: 20020152396Abstract: Deterring a rollback attack against a first database by determining if the first database is corrupted, the first database being associated with a first authentication code, determining if a second database is corrupted when the first database is corrupted, the second database being associated with a second authentication code, the second database having contents substantially the same as the first database, and when the second database is not corrupted, recalculating the second authentication code using a portion of the first authentication code, copying the second database over the first database, and proceeding with authorized operations for processing content by an application program.Type: ApplicationFiled: April 11, 2001Publication date: October 17, 2002Inventors: Michael S. Fox, Keith L. Shippy, Thomas J. Brown
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Patent number: 6152138Abstract: A kinesiological mouthpiece includes a strap assembly with a bridge, a pair of extensions extending generally rearwardly and outwardly from the bridge and a pair of wings extending generally rearwardly from the extensions. The strap assembly is flexible for forming in a generally U-shaped use configuration. The wings are displaced at a different level from the bridge whereby the bridge can be positioned generally between the lower teeth and the lower lip with the wings approximately located on bite lines of the back teeth. A pair of bitepad assemblies are rotatably and longitudinally-adjustably mounted on the wings and each includes a bitepad with upper and lower contact surfaces for contacting by the back teeth.Type: GrantFiled: February 23, 1999Date of Patent: November 28, 2000Inventors: Thomas J. Brown, Thomas W. Brown
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Patent number: 6086462Abstract: A powered coping and profile cutting and/or sanding apparatus is able to impart any shape to the surface of a body of material (17) at any angle, simple or compound, relative to the body of material. The apparatus comprises a reciprocating "frame"(36) encasing thin stacking metal sheets (42) which are adjustable in a forward/backward direction for allowing multiple shape setups. The sheets (42), which are oriented vertically, have saw teeth at their top sections (42a) and no teeth at their bottom sections (42b). Adhesive-backed sandpaper (78) is affixed to the bottom section (42b) after the shape is set. This allows a cutting phase and a sanding phase with the same profile. The entire reciprocating frame (36) pivots multidirectionally within two planes, and may be locked at any angle. The reciprocating frame (36) is movable in a forward/backward direction.Type: GrantFiled: December 30, 1997Date of Patent: July 11, 2000Inventor: Thomas J. Brown
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Patent number: 5958442Abstract: Oncostatin M is employed in methods to treat acute and chronic gastrointestinal inflammation, rheumatoid arthritis and multiple sclerosis.Type: GrantFiled: October 24, 1997Date of Patent: September 28, 1999Assignee: Bristol-Myers Squibb CompanyInventors: Philip M. Wallace, Thomas J. Brown
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Patent number: 5873365Abstract: A kinesiological mouthpiece includes a strap assembly with a bridge, a pair of extensions extending generally rearwardly and outwardly from the bridge and a pair of wings extending generally rearwardly from the extensions. The strap assembly is flexible for forming in a generally U-shaped use configuration. The wings are displaced at a different level from the bridge whereby the bridge can be positioned generally between the lower teeth and the lower lip with the wings approximately located on bite lines of the back teeth. A pair of bitepad assemblies are rotatably and longitudinally-adjustably mounted on the wings and each includes a bitepad with upper and lower contact surfaces for contacting by the back teeth.Type: GrantFiled: August 12, 1996Date of Patent: February 23, 1999Inventor: Thomas J. Brown
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Patent number: 5814307Abstract: The present invention relates to methods of using oncostatin M (OM). In particular, it relates to the use of OM to stimulate interleukin 6 (IL-6) synthesis in target cells, especially human endothelial cells. The resultant IL-6, in turn, may perform a variety of functions such as cell growth regulation, leukocyte differentiation, and tumor inhibition. Furthermore, the present invention also relates to the use of OM to treat cytopenias, including anemia and thrombocytopoiesis, and to increase tolerance to irradiation and cytotoxic drugs. Therefore, the methods of the invention may have a wide range of applications, including, but not limited to, the inhibition of tumor growth, the treatment of cytopenias, and to increase the tolerance to radio- and chemotherapy. OM may be used in combination with various cytokines, including erythropoietin, colony-stimulating factors, interleukin-3 or thrombopoietin.Type: GrantFiled: September 26, 1994Date of Patent: September 29, 1998Assignee: Bristol-Myers Squibb CompanyInventors: Philip M. Wallace, Thomas J. Brown
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Patent number: 5428012Abstract: Novel compositions comprising Oncostatin M and congeners thereof, as well as methods for their preparation and methods for their use are provided. The compositions may be prepared by isolation from natural sources, or by recombinant means in either prokaryotic or eukaryotic host cells. In addition, the DNA and polypeptide sequences for Oncostatin M are disclosed. The compositions find use in modulating growth of cells, in particular inhibition of tumor cell proliferation, and stimulation of normal cell growth, especially cells involved in hematopoiesis. Cell growth inhibition compositions may additionally include an adjunctive agent comprising at least one of a transforming growth factor, tumor necrosis factor, or an interferon. Receptors having high affinity for Oncostatin M may additionally be used to screen polypeptides for Oncostatin M-like activity. Methods for use of antibodies to the compositions and probes specific for Oncostatin M mRNA as a means for detecting tumor cells are also provided.Type: GrantFiled: July 1, 1993Date of Patent: June 27, 1995Assignee: Oncogen Limited PartnershipInventors: Mohammed Shoyab, Joyce M. Zarling, Hans Marquardt, Marcia B. Hanson, Thomas J. Brown
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Patent number: D373421Type: GrantFiled: August 8, 1995Date of Patent: September 3, 1996Inventor: Thomas J. Brown