Patents by Inventor Thomas J. Fleck
Thomas J. Fleck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7435832Abstract: The present invention provides crystals, and compositions thereof, wherein the crystals include a malic acid salt of N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide. Methods of preparing such crystals are also disclosed.Type: GrantFiled: April 26, 2007Date of Patent: October 14, 2008Assignee: Pharmacia & Upjohn CompanyInventors: Michael Hawley, Thomas J. Fleck, Stephen P. Prescott, Mark T. Maloney
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Publication number: 20040110787Abstract: The present invention provides a compound of formula as described herein, which are useful as antiviral agents, in particular, as agents against viruses of the herpes family.Type: ApplicationFiled: August 27, 2003Publication date: June 10, 2004Inventors: Mark E. Schnute, Michele M. Cudahy, David John Anderson, Thomas M. Judge, Thomas J. Fleck, Paul Matthew Herrinton, Sajiv K. Nair, Allen Scott, William R. Perrault, Steve P. Tanis, James A. Nieman, Sarah A. Collier, Bruce F. Fleck
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Publication number: 20030069298Abstract: The present invention provides crystals, and compositions thereof, wherein the crystals include a malic acid salt of N-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide. Methods of preparing such crystals are also disclosed.Type: ApplicationFiled: August 13, 2002Publication date: April 10, 2003Applicant: PHARMACIA & UPJOHN COMPANYInventors: Michael Hawley, Thomas J. Fleck, Stephen P. Prescott, Mark T. Maloney
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Patent number: 6140510Abstract: This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in figure BG.sub.4-1, below. ##STR1## where R.sup.50, R.sup.6 and R.sup.9 are defined independently and are H, --(C.sub.1 -C.sub.8)alkyl, --(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.6 -C.sub.12 aryl), --(C.sub.1 -C.sub.8)alkyl-(C.sub.6 -C.sub.12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C.sub.6 -C.sub.12 aryl), (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3) alkoxy, halogen, trifluoromethyl;where R.sup.2 is --(C.sub.1 -C.sub.8)alkyl, --(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.6 -C.sub.12 aryl), --(C.sub.1 -C.sub.8)alkyl-(C.sub.6 -C.sub.Type: GrantFiled: May 10, 1999Date of Patent: October 31, 2000Assignee: Pharmacia & Upjohn CompanyInventors: William W. McWhorter, Thomas J. Fleck, Bruce A. Pearlman
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Patent number: 6097915Abstract: In an electrostatographic imaging apparatus employing at least one charging device, scorotron which consists of one or more fine wires supported on insulated blocks spaced between the photoconductive surface and a conductive or insulative surface parallel to it. A screen or grid is interposed between the corona wires and the photoconductive surface and the grid is maintained at a potential roughly equal to the potential desired on the photoconductive surface. The scorotrons geometry, the individual wires are from 1/2 to 11/2 inches apart and are spaced from the grid by about 3/4 of an inch. Field enhancement electrode(s) are placed on the screen and are biased at the same potential as the screen. The field enhancement electrode(s) enhance electrical performance.Type: GrantFiled: May 14, 1999Date of Patent: August 1, 2000Assignee: Xerox CorporationInventors: Thomas J. Fleck, Kenneth W. Pietrowski, Jing qing Song
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Patent number: 5962697Abstract: This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in figure BG.sub.4-1, below. ##STR1## where R.sup.50, R.sup.6 and R.sup.9 are defined independently and are H, --(C.sub.1 -C.sub.8)alkyl, --(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.6 -C.sub.12 aryl), --(C.sub.1 -C.sub.8) alkyl-(C.sub.6 -C.sub.12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C.sub.6 -C.sub.12 aryl), (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3) alkoxy, halogen, trifluoromethyl;where R.sup.2 is --(C.sub.1 -C.sub.8)alkyl, --(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.6 -C.sub.12 aryl), --(C.sub.1 -C.sub.8)alkyl-(C.sub.6 -C.sub.Type: GrantFiled: July 24, 1997Date of Patent: October 5, 1999Assignee: Pharmacia & Upjohn CompanyInventors: Thomas J. Fleck, Bruce A. Pearlman, William W. McWhorter, Jr.
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Patent number: 5837870Abstract: The present invention includes processes for producing 5-hydroxymethyl substituted oxazolidinone alcohols (III) from carbamates (IIA) or a trifluoroacetamide (IIB) using a dihydroxy compound (I) or glycidol (IV) starting material and for the transformation of the hydroxymethyl substituted oxazolidinone alcohols (III) to the corresponding amino compounds, 5-aminomethyl substituted oxazolidinone amines (VII) which are acylated to form commercially useful antibacterial 5-acylamidomethyl substituted oxazolidinone (VIII).Type: GrantFiled: March 28, 1997Date of Patent: November 17, 1998Assignee: Pharmacia & Upjohn CompanyInventors: Bruce A. Pearlman, William R. Perrault, Michael R. Barbachyn, Peter R. Manninen, Dana S. Toops, David J. Houser, Thomas J. Fleck
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Patent number: 5773610Abstract: This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in FIG. BG.sub.4-1, where R.sup.50, R.sup.6 and R.sup.9 are defined independently and are H, -(C.sub.1 -C.sub.8)alkyl, -(C.sub.3 -C.sub.8)cycloalkyl, -(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, -(C.sub.6 -C.sub.12 aryl), -(C.sub.1 -C.sub.8)alkyl-(C.sub.6 -C.sub.12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C.sub.6 -C.sub.12 aryl), (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy, halogen, trifluoromethyl; where R.sup.2 is -(C.sub.1 -C.sub.8)alkyl, -(C.sub.3 -C.sub.8)cycloalkyl, -(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, -(C.sub.6 -C.sub.12 aryl), -(C.sub.1 -C.sub.8)alkyl-(C.sub.6 -C.sub.Type: GrantFiled: November 1, 1995Date of Patent: June 30, 1998Assignee: Pharmacia & Upjohn CompanyInventors: William W. McWhorter, Thomas J. Fleck, Bruce A. Pearlman
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Patent number: 5613172Abstract: Printing machines and systems which incorporate recharging stations comprised of two corona generating devices which act together to recharge a previously developed photoreceptor to a predetermined potential. The first corona generating device recharges the photoreceptor's surface to a greater absolute potential than a predetermined potential which the surface is to have after being recharged. The second corona generating device reduces the photoreceptor's surface to the potential that it is to have. The second corona generating device is comprised of a plurality of spaced apart coronodes which each can impress charges on the photoreceptor's surface. The second corona generating device receives electrical inputs and applies DC potentials to the coronodes such that adjacent coronodes have opposite polarities.Type: GrantFiled: August 25, 1995Date of Patent: March 18, 1997Assignee: Xerox CorporationInventors: Kenneth W. Pietrowski, Thomas J. Fleck
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Patent number: 5600430Abstract: In a multi-color imaging apparatus utilizing a recharge step between two image creation steps for recharging a charge retentive surface to a predetermined potential pursuant to forming the second of the two images, a first corona generating device recharges the charge retentive surface to a higher absolute potential than a predetermined potential, and then a second corona generating device recharges the charge retentive surface to the predetermined potential. An electrical charge associated with the first image is substantially neutralized after being recharged by the first and second corona generating device.Type: GrantFiled: November 30, 1994Date of Patent: February 4, 1997Assignee: Xerox CorporationInventors: Jeffrey J. Folkins, Roger L. Bullock, Thomas J. Fleck, Kenneth W. Pietrowski, Charles H. Tabb, Zhao-Zhi Yu, Mark A. Gwaltney