Patents by Inventor Thomas J. Goodwin

Thomas J. Goodwin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10724030
    Abstract: The present invention provides a system for delivering a time-varying stimulation field to a subject. In the system, a power source, a control component and a transmission component operate as a stimulation field generator to provide a predetermined time-varying stimulation field to up-regulate or down-regulate an expression level of human genes. The present invention also provides a wearable apparatus for delivering the time-varying magnetic field to mammalian cells associated with bone formation in a subject. The wearable apparatus contains the stimulation field generator in a housing. The resulted modification on gene regulation of these genes and mammalian cells promotes the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: July 28, 2020
    Assignee: United States of America as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Publication number: 20200017848
    Abstract: Provided herein are systems and methods for culturing tissue-like assemblies of cells in the presence of a pulsating alternating ionic magnetic resonance field. The cells are introduced into a growth module in fluid connection with a nutrient module in which the gravity vector of the growth module is continually randomized and cultured in the presence of the alternating ionic magnetic resonance field.
    Type: Application
    Filed: September 26, 2019
    Publication date: January 16, 2020
    Applicant: United States of America as Represented by the Administrator of the National Aeronautics and Space
    Inventors: Thomas J. Goodwin, Moses J. Kushman
  • Publication number: 20190297814
    Abstract: The present invention provides an inbred corn line designated HID3768, IID5385, KFX5360, KID7244, LFF6371, LFF7869, or MIJ7209, methods for producing a corn plant by crossing plants of the inbred line HID3768, IID5385, KFX5360, KID7244, LFF6371, LFF7869, or MIJ7209 with plants of another corn plant. The invention further encompasses all parts of inbred corn line HID3768, IID5385, KFX5360, KID7244, LFF6371, LFF7869, or MIJ7209, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line HID3768, IID5385, KFX5360, KID7244, LFF6371, LFF7869, or MIJ7209, and plants produced according to these methods.
    Type: Application
    Filed: March 26, 2019
    Publication date: October 3, 2019
    Applicant: Syngenta Participations AG
    Inventors: Benjamin Ford, Azzeddine Douiyssi, William H. Goodwin, Russel Pinnisch, Jason Cromley, Thomas J. Prest
  • Publication number: 20180171327
    Abstract: The present invention provides a system for delivering a time-varying stimulation field to a subject. In the system, a power source, a control component and a transmission component operate as a stimulation field generator to provide a predetermined time-varying stimulation field to up-regulate or down-regulate an expression level of human genes. The present invention also provides a wearable apparatus for delivering the time-varying magnetic field to mammalian cells associated with bone formation in a subject. The wearable apparatus contains the stimulation field generator in a housing. The resulted modification on gene regulation of these genes and mammalian cells promotes the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Application
    Filed: February 19, 2018
    Publication date: June 21, 2018
    Applicant: United States of America as Represented by the Administrator of the National Aeronautics and Spac
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Patent number: 9914920
    Abstract: Provided herein are a culture apparatus, culture systems and an alternating ionic magnetic resonance electromagnetic chamber for culturing cells, tissues or organoid bodies or for delivering a pulsating alternating ionic magnetic resonance field to an object of interest including the above or to an animal, human or plant. The culture apparatus comprises a culture unit having growth and nutrient modules and a randomizing adapter to continually randomize the gravity vector in the growth module. The culture systems further comprise the alternating ionic magnetic resonance electromagnetic chamber.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: March 13, 2018
    Inventors: Thomas J Goodwin, Moses J Kushman
  • Patent number: 9896681
    Abstract: The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation, up-regulation and/or down-regulation. The method comprises steps of tuning the predetermined profiles of one or more time-varying stimulation fields by manipulating the B-Field magnitude, rising slew rate, rise time, falling slew rate, fall time, frequency, wavelength, and duty cycle, and exposing mammalian cells or tissues to one or more tuned time-varying stimulation fields with predetermined profiles. Examples of mammalian cells or tissues are chondrocytes, osteoblasts, osteocytes, osteoclasts, nucleus pulposus, associated tissue, or any combination. The resulted modification on gene regulation of these cells, tissues or bones may promote the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: February 20, 2018
    Assignee: The United States of America as represented by the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Publication number: 20170298341
    Abstract: Provided herein are models comprising a tissue-like assembly of cells tissues or organoid bodies cultured in the presence of a pulsating alternating ionic magnetic resonance field. The cells, tissues or organoid bodies are introduced into a culture unit comprising growth and nutrient modules in which the gravity vector of the growth unit is continually randomized and cultured in the presence of the alternating ionic magnetic resonance field.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 19, 2017
    Inventors: Thomas J. Goodwin, Moses J. Kushman
  • Publication number: 20170298340
    Abstract: Provided herein are a culture apparatus, culture systems and an alternating ionic magnetic resonance electromagnetic chamber for culturing cells, tissues or organoid bodies or for delivering a pulsating alternating ionic magnetic resonance field to an object of interest including the above or to an animal, human or plant. The culture apparatus comprises a culture unit having growth and nutrient modules and a randomizing adapter to continually randomize the gravity vector in the growth module. The culture systems further comprise the alternating ionic magnetic resonance electromagnetic chamber.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 19, 2017
    Inventors: Thomas J. Goodwin, Moses J. Kushman
  • Publication number: 20140342428
    Abstract: The present invention provides methods to modify the genetic regulation of mammalian tissue, bone, cells or any combination thereof by preferential activation, up-regulation and/or down-regulation. The method comprises steps of tuning the predetermined profiles of one or more time-varying stimulation fields by manipulating the B-Field magnitude, rising slew rate, rise time, falling slew rate, fall time, frequency, wavelength, and duty cycle, and exposing mammalian cells or tissues to one or more tuned time-varying stimulation fields with predetermined profiles. Examples of mammalian cells or tissues are chondrocytes, osteoblasts, osteocytes, osteoclasts, nucleus pulposus, associated tissue, or any combination. The resulted modification on gene regulation of these cells, tissues or bones may promote the retention, repair of and reduction of compromised mammalian cartilage, bone, and associated tissue.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 20, 2014
    Applicant: USA as Represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Patent number: 8795147
    Abstract: An apparatus and method to modify the genetic regulation of mammalian tissue, bone, or any combination.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: August 5, 2014
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Linda C. Shackelford
  • Publication number: 20130267020
    Abstract: Provided herein are a culture apparatus, culture systems and an alternating ionic magnetic resonance electromagnetic chamber for culturing cells, tissues or organoid bodies or for delivering a pulsating alternating ionic magnetic resonance field to an object of interest including the above or to an animal, human or plant. The culture apparatus comprises a culture unit having growth and nutrient modules and a randomizing adapter to continually randomize the gravity vector in the growth module. The culture systems further comprise the alternating ionic magnetic resonance electromagnetic chamber.
    Type: Application
    Filed: April 9, 2013
    Publication date: October 10, 2013
    Inventors: Thomas J. Goodwin, Moses J. Kushman
  • Publication number: 20130267003
    Abstract: Provided herein are methods for culturing cells, tissues or organoid bodies in the presence of a pulsating alternating ionic magnetic resonance field and models comprising a tissue-like assembly of the cells so cultured. The cells, tissues or organoid bodies are introduced into a culture unit comprising growth and nutrient modules in which the gravity vector of the growth unit is continually randomized and cultured in the presence of the alternating ionic magnetic resonance field.
    Type: Application
    Filed: April 9, 2013
    Publication date: October 10, 2013
    Inventors: Thomas J. Goodwin, Moses J. Kushman
  • Patent number: 8338114
    Abstract: Three-dimensional human broncho-epithelial tissue-like assemblies (TLAs) are produced in a rotating wall vessel (RWV) with microcarriers by coculturing mesenchymal bronchial-tracheal cells (BTC) and bronchial epithelium cells (BEC). These TLAs display structural characteristics and express markers of in vivo respiratory epithelia. TLAs are useful for screening compounds active in lung tissues such as antiviral compounds, cystic fibrosis treatments, allergens, and cytotoxic compounds.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: December 25, 2012
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventor: Thomas J. Goodwin
  • Publication number: 20100178680
    Abstract: A rotatable perfused time varying electromagnetic force bioreactor with a rotatable perfusable culture chamber and a time varying electromagnetic force source operatively connected to the rotatable perfusable culture chamber. In use, the rotatable perfused time varying electromagnetic force bioreactor supplies a time varying electromagnetic force to the rotatable perfusable culture chamber of the rotatable perfused time varying electromagnetic force bioreactor to expand cells contained therein.
    Type: Application
    Filed: June 26, 2006
    Publication date: July 15, 2010
    Applicants: REGENETECH, INC., NASA
    Inventors: Thomas J. Goodwin, Clayton R. Parker
  • Patent number: 7601114
    Abstract: An apparatus is introduced for the use of enhancing tissue repair in mammals. The apparatus includes a sleeve; an electrically conductive coil; a sleeve support; an electrical circuit configured to supply the coil with a square wave time varying electrical current sufficient to create approximately 0.05 gauss to 0.5 gauss. When in use, the sleeve of the apparatus is placed on a mammalian body part and the time varying electromagnetic force of from approximately 0.05 gauss to 0.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: October 13, 2009
    Assignees: Regenetech, Inc., The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Clayton R. Parker
  • Publication number: 20090156883
    Abstract: A time varying electromagnetic force sleeve (10) comprising a time varying electromagnetic force source (3) operatively connected to a coil (1) having a conductive portion (7), a coil support (5), and an interior portion wherein the interior portion defines a space that removably receives a mammalian body part. Also provided is a method for enhancing repair of defective tissue of a mammal.
    Type: Application
    Filed: June 23, 2006
    Publication date: June 18, 2009
    Inventors: Thomas J. Goodwin, Clayton R. Parker
  • Publication number: 20090081751
    Abstract: A composition is disclosed with the composition comprising a mixture of natively glycosylated mammalian biological molecules produced by electromagnetically stimulating living mammalian cells.
    Type: Application
    Filed: April 23, 2008
    Publication date: March 26, 2009
    Inventors: Thomas J. Goodwin, Donnie Rudd
  • Patent number: 7456019
    Abstract: An improved three-dimensional cell to tissue development process using a specific time varying electromagnetic force, pulsed, square wave, with minimum fluid shear stress, freedom for 3-dimensional spatial orientation of the suspended particles and localization of particles with differing or similar sedimentation properties in a similar spatial region.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: November 25, 2008
    Assignees: Regenetech, Inc., The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Clayton R. Parker
  • Patent number: 7179217
    Abstract: An apparatus is disclosed for enhancing tissue repair in mammals, with the apparatus comprising: a sleeve for encircling a portion of a mammalian body part, said sleeve comprising an electrically conductive coil capable of generating an electromagnetic field when an electrical current is applied thereto, means for supporting the sleeve on the mammalian body part; and means for supplying the electrically conductive coil with a square wave time varying electrical current sufficient to create a time varying electromagnetic force of from approximately 0.05 gauss to 0.05 gauss within the interior of the coil in order that when the sleeve is placed on a mammalian body part and the time varying electromagnetic force of from approximately 0.05 gauss to 0.
    Type: Grant
    Filed: June 29, 2005
    Date of Patent: February 20, 2007
    Assignees: Regenetech, Inc., The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Clayton R. Parker
  • Patent number: 6673597
    Abstract: The present invention provides systems for growing two or three dimensional mammalian cells within a culture medium facilitated by an electromagnetic field, and preferably, a time varying electromagnetic field. The cells and culture medium are contained within a fixed or rotating culture vessel, and the electromagnetic field is emitted from at least one electrode. In one embodiment, the electrode is spaced from the vessel. The invention further provides methods to promote neural tissue regeneration by means of culturing the neural cells in the claimed system. In one embodiment, neuronal cells are grown within longitudinally extending tissue strands extending axially along and within electrodes comprising electrically conductive channels or guides through which a time varying electrical current is conducted, the conductive channels being positioned within a culture medium.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: January 6, 2004
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: David A. Wolf, Thomas J. Goodwin