Abstract: A catheter assembly is provided having a working lumen and a guide. The guide is configured to position a fragmentizing device within the working lumen. The guide is configured to prevent or minimize any unintended movement of a distal section of the fragmentizing device within the working lumen when the distal section of the fragmentizing device is positioned at a distal end of the working lumen.

Abstract: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).

Abstract: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).

Abstract: Disclosed is a method for identifying an individual who has an altered risk for developing colorectal cancer comprising detecting a single nucleotide polymorphism (SNP).

Abstract: Gene expression patterns were analyzed in CD40-sensitive and CD40-resistant diffuse large-cell B-lymphoma (DLCBL) cell lines to identify signaling pathways which are involved in CD40-mediated apoptosis. CD40-resistant lines expressed pre-B cell markers including RAG and VPREB, whereas CD40-sensitive cells resembled mature B-cells and expressed higher levels of transcripts encoding several members of the CD40 signaling pathway including LCK and VAV. In addition, CD40 sensitive DLCBL cell lines also displayed constitutive activation of ERK and failed to undergo apoptosis when ERK phosphorylation was inhibited. In contrast, CD40 resistant lines showed no constitutive activation of ERK and no increase in ERK activity in response to CD40 stimulation. The invention includes methods to differentiate between CD40-sensitive and CD-40 resistant cells based on these differences in gene expression.

Abstract: Novel alterations in the glycerol kinase gene are described. Also described are methods of predicting or assisting in the prediction of impaired glucose tolerance and type 2 diabetes mellitus.

Abstract: The invention provides nucleic acid segments of the human genome, particularly nucleic acid segments from a gene, including polymorphic sites. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also provided. The nucleic acids, primers and probes are used in applications such as phenotype correlations, forensics, paternity testing, medicine and genetic analysis.

Abstract: Novel alterations in the glycerol kinase gene are described. Also described are methods of predicting or assisting in the prediction of impaired glucose tolerance and type 2 diabetes mellitus.

Abstract: Polymorphic nucleic acid molecules encoding the very low density lipoprotein receptor are described, as well as gene products encoded by these nucleic acid molecules. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also described, along with methods of use therefor.

Abstract: Isolated spastin genes and fragments thereof, as well as Spastin proteins and fragments thereof are disclosed. Also disclosed are altered forms of spastin, as well as methods for the diagnosis and treatment of neurodegenerative disease.

Abstract: Novel alterations in the glycerol kinase gene are described. Also described are methods of predicting or assisting in the prediction of impaired glucose tolerance and type 2 diabetes mellitus.

Abstract: The complete genomic structure of the peroxisome proliferator-activated receptor alpha gene is described. Also described are the identification of novel single nucleotide polymorphisms and association with higher plasma LDL-cholesterol and total and LDL-apolipoprotein B concentrations.

Abstract: Methods and kits for determining an individual's susceptibility to atopy-associated disease are described. Also described are nucleic acids comprising alleles linked to atopy-associated diseases.

Abstract: The complete genomic structure of the peroxisome proliferator-activated receptor alpha gene is described. Also described are the identification of novel single nucleotide polymorphisms and association with higher plasma LDL-cholesterol and total and LDL-apolipoprotein B concentrations.

Abstract: Methods for determining an individual's susceptibility to obesity or to a health disorder associated with obesity, comprising detecting an allele at a polymorphic site genetically linked to the resistin gene locus, wherein the allele is further linked to obesity, and wherein detection of the allele is indicative of the patient's susceptibility to a health disorder associated with obesity are provided. Also included in the present disclosure are nucleic acid molecules containing allelic variants at polymorphic sites.

Abstract: Polymorphic nucleic acid molecules encoding the very low density lipoprotein receptor are described, as well as gene products encoded by these nucleic acid molecules. Allele-specific primers and probes hybridizing to regions flanking or containing these sites are also described, along with methods of use therefor.

Abstract: Methods of detecting expanded nucleotide repeats in genomic DNA in a biological sample are disclosed and methods for the diagnosis of pathological and potentially pathological conditions in an individual based on the detection of the presence of expanded nucleotide repeats.

Abstract: Natural antioxidant compositions comprising ascorbyl palmitate, a mixed tocopherol concentrate, and rosemary extract are disclosed. The compositions can be used in place of synthetic antioxidants and are effective even in the presence of metals and minerals. In one embodiment of the invention, the inventive composition is added to a dietary vitamin/mineral supplement.

Abstract: An aluminium reduction cell includes an anode 10, electrolyte 12, a cathode 14, a potlining 16 which may be of alumina and cathode current collectors embedded therein. The collectors include a section comprising a major proportion by volume of bodies 22, e.g. of titanium diboride or a TiB.sub.2 /Al cermet, joined or surrounded by aluminium, the section being so positioned that the aluminium is at least partly fluid when the cell is in operation. The bodies, which are preferably close-packed, may be cubic or cuboid or in the form of sheets or thin slabs arranged with their major faces parallel to one another and to the axis of the collector section. The collectors show good electrical conductivity together with satisfactory resistance to magnetic stirring and impact and transverse forces.

Abstract: An electrolytic reduction cell for the production of aluminium has current collector bars running across the floor of the cell unitarily or in separate sections. Deformation of the molten metal/electrolytic bath interface is reduced by leading current out of the collector bars or bar sections at positions remote from their ends by connector bars connected to said positions.