Abstract: The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B) or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.

Abstract: A digital certificate associating a unique identifier for a computer-based appliance with an authentication key pair for that appliance is obtained from a certificate authority using a different, manufacturing key pair for the appliance. The manufacturing key pair may be generated by the appliance at or about its time of manufacture. The public key portion of the manufacturing key pair along with the unique identifier for the appliance may be provided via secure means to the certificate authority prior to the request for the digital certificate concerning the authentication key pair. Eventually, the digital certificate associated with the authentication key pair may be used by the appliance when joining a network, as part of a one-way or two-way authentication process.

Abstract: A first computer-based device is authenticated at a second computer-based device communicatively coupled thereto through use of a unique identifier and an encrypted token, each received from the first device. Following the authentication, configuration information for the first device is sent from the second device to the first device and the first device is authorized to join a network that includes the second device. Further, permissions related to the network may be granted to the first device.

Abstract: A policy distribution server provides, on a subscription basis, policy updates to effect desired behaviors of network intermediary devices. The policy updates may specify caching policies, and may in some instances, include instructions for data collection by the network intermediary devices. Data collected in accordance with such instructions may be used to inform future policy updates distributed to the network intermediary devices.

Abstract: A caching device is configured to determine whether an object received or currently stored at the caching device should be (or continue to be) cached at the caching device, even if the object is otherwise cacheable. If so, the object is cached (or retained) at the caching device, otherwise, it is not. The determination as to whether or not the object should be cached or, if already cached, retained at the caching device may be made on the basis of a worthiness determination which evaluates the object on the basis of one or more parameters or attributes of the object, which worthiness may be one part of an overall value determination for the object.

Abstract: Methods and systems of the present invention are provided for performing proxy control functions in an environment including one or more work machines. Such methods and systems may leverage one or more gateways to serve as a proxy for one or more distinct modules. A gateway, located in a work machine, may be programmed with proxy logic that performs functions associated with certain modules used in a work machine environment. The gateway may monitor a data link and retrieve broadcasted messages. The broadcasted messages may include source and/or destination module address identifiers. The gateway may retrieve messages from the data link based on a determination that the message is destined for a module for which the gateway serves as a proxy. The gateway may route a retrieved message, using a mapping structure, to the appropriate proxy logic that performs functions associated with the destination module.

Abstract: Provided is a method for heat treating a precipitation-hardened article having a thick section and a thin section so that the thin section can be solution annealed while the metallurgical structure of the thick section is substantially unaffected by the solution-annealing process. The method restores the microstructure of the thin section uniformly by solution annealing the thin section to achieve a preselected microstructure but without affecting the microstructure of the thick section.

Abstract: A system and method to securely deliver software updates to an appliance are provided. The system comprises a key generator, a reporting module, and a certificate signing request (CSR) module. The key generator may be configured to generate, at the processing system, verification data for the processing system. The reporting module may be configured to communicate the verification data from the processing system to a verification database. The certificate signing request (CSR) module may be configured to obtain a signed certificate from a certificate authority (CA) based on the verification data stored in the verification database.

Abstract: Consistent with one embodiment of the invention, a wireless mobile device is configured to receive a configuration file from a configuration server. After receiving the configuration file, the wireless mobile device establishes a wireless communication session with a computing device within proximity of the mobile device. The mobile device is configured to send the configuration file to the computing device so as to enable a configuration application executing on the computing device to configure the computing device in accordance with configuration information included in the configuration file.

Abstract: Provided is a method for heat treating a precipitation-hardened article having a thick section and a thin section so that the thin section can be solution annealed while the metallurgical structure of the thick section is substantially unaffected by the solution-annealing process. The method restores the microstructure of the thin section uniformly by solution annealing the thin section to achieve a preselected microstructure but without affecting the microstructure of the thick section.

Abstract: In response to an indication of a desire to initiate a secure communication session (e.g., a session utilizing a the SSL communication protocol) with a computer resource, a digital certificate indicative of whether or not a user consents to monitoring of the secure communication session is requested. The response to this request will permit or deny such monitoring, allowing the session to proceed or be cancelled, accordingly.

Abstract: Systems, methods, and computer products for protecting information during troubleshooting are provided. A dumping mechanism includes marking at least one of a plurality of memory regions in the computer-readable medium as non-dumpable, initiating a core dump, determining which memory regions of the plurality regions are non-dumpable, and dumping the contents only of memory regions not marked as non-dumpable.

Abstract: Methods and systems are provided for performing protocol conversions in an environment including a work machine having one or more modules coupled to one or more data links. Such methods and systems may leverage one or more gateways to perform tunneling, translating, and bridging operations. Tunneling processes may include receiving a message from a source module in a first protocol, encapsulating the message within transmission units of a second protocol, and transmitting the encapsulated message via the second protocol. Translating processes may include receiving, by the gateway, a message in a first data link protocol including a parameter identifier. The gateway may match the parameter identifier with a parameter identifier included in a translation table and scale associated parameter data using a scale factor corresponding to a second data link protocol. The gateway may then provide the scaled parameter data to a module using the second data link protocol.

Abstract: A method and system are provided to perform a process of managing communications in an environment including a mobile work machine having one or more on-board data links connected to one or more on-board modules and a gateway and including one or more off-board data links connected to one or more off-board systems and the gateway. The process is performed by the gateway and includes receiving a request generated by a source device and transmitted on a first data link. In one embodiment, the first data link may be either one of the on-board data links and one of the off-board data links. Based on the request, the gateway selectively executes a server application that performs a server process. Further, the gateway identifies a destination device associated with the request, configures the request to a format compatible with the destination device, and provides the formatted request to the destination device.

Abstract: A first computer-based device is authenticated at a second computer-based device communicatively coupled thereto through use of a unique identifier and an encrypted token, each received from the first device. Following the authentication, configuration information for the first device is sent from the second device to the first device and the first device authorized to join a network that includes the second device. Further, permissions related to the network may be granted to the first device.

Abstract: A digital certificate associating a unique identifier for a computer-based appliance with an authentication key pair for that appliance is obtained from a certificate authority using a different, manufacturing key pair for the appliance. The manufacturing key pair may be generated by the appliance at or about its time of manufacture. The public key portion of the manufacturing key pair along with the unique identifier for the appliance may be provided via secure means to the certificate authority prior to the request for the digital certificate concerning the authentication key pair. Eventually, the digital certificate associated with the authentication key pair may be used by the appliance when joining a network, as part of a one-way or two-way authentication process.

Abstract: Consistent with one embodiment of the invention, a wireless mobile device is configured to receive a configuration file from a configuration server. After receiving the configuration file, the wireless mobile device establishes a wireless communication session with a computing device within proximity of the mobile device. The mobile device is configured to send the configuration file to the computing device so as to enable a configuration application executing on the computing device to configure the computing device in accordance with configuration information included in the configuration file.

Abstract: A fixture and method for repairing superalloy articles. The fixture ideally holds the article in place if repairs are made. An interface between the fixture and the article facilitate transfer of heat between the article and the fixture so that the article can be differentially heat treated. A portion of the article extends from the fixture. This portion of the article, which may be repaired within the fixture or may be repaired elsewhere, is solution heat treated while in the fixture so that the area extending from the fixture is solutioned, while heat is transferred from the article through the fixture, thereby preventing the temperature of the portion of the article within the fixture from being elevated so as to modify its microstructure. The solutioned portion can then be heat treated, while in the fixture, to precipitation harden it as desired.

Abstract: A process for refurbishing a worn surface of a shroud support component of a turbomachine, as well as a shroud support component refurbished with the process. The process generally entails removing a surface region of the worn surface so as to define a repair surface on the component. A braze tape formed from a slurry to comprise a braze material and a wear-resistant alloy is then applied to the repair surface, followed by a heat treatment to cause the braze tape to diffusion bond to the repair surface so as to define a built-up surface. The built-up surface is then machined to define a wear-resistant coating on the component.

Abstract: A heating apparatus and method for pre-weld heat treating, welding and post-weld heat treating a superalloy article in a single enclosure while avoiding oxidation of the article. The enclosure is preferably equipped with a one-way valve that permits the escape of gases, but otherwise seals the enclosure to prevent the ingress of air during welding and heat treatment as a result of thermal gradients induced when the article is inductively heated. To provide access to the article and a device used to weld the article, the enclosure is equipped with gloves by which the welding device and the article can be manipulated while a nonreactive atmosphere is fully maintained within the enclosure and the article is inductively heating.