Patents by Inventor Thomas J. Knight

Thomas J. Knight has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240093287
    Abstract: The present disclosure relates to compositions and methods for reducing the concentration of extendable free and buried primers relative to amplification product in a sample. The disclosed methods and compositions can be used to reduce or eliminate index hopping in a next generation sequencing (NGS) platform.
    Type: Application
    Filed: July 30, 2021
    Publication date: March 21, 2024
    Inventors: Keith Robison, Douglas G. Smith, Adam J. Meyer, Andrew J. Mitchell, Alex Plocik, Thomas F. Knight
  • Patent number: 11930304
    Abstract: This invention provides an improved display system and method that is created by adjusting the properties of one or more displays to obtain coarse control over display behavior, by using sensors to optimize display parameters. The display is further improved by constructing a display map by selectively driving the display and sensing the optical image created. Furthermore, the sensors are used to ensure that the resulting optimized display meets target quality measurements over time, potentially taking into account ambient conditions. The system reports on status, and can predict when it no longer meets a quality target. It is able to optimize a display system and keep it optimized over time. Individual displays with the display system can have operating points that are matched to each other. Corrections to the input image signal, delivering improved display system performance, are minimized, and therefore, unwanted artifacts of those changes can be minimized.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: March 12, 2024
    Assignee: Scalable Display Technologies, Inc.
    Inventors: Rajeev J. Surati, Samson J. Timoner, Kevin Amaratunga, Thomas F. Knight, Jr.
  • Patent number: 10297532
    Abstract: A stacked interconnect structure includes a first conductive layer, a second conductive layer, and a first dielectric layer disposed between the first and second conductive layers and having an air gap in a portion of the first dielectric layer that separates the first and second conductive layers. A second dielectric layer is parallel to the first conductive layer, a third dielectric layer overlays a portion of the second dielectric layer and contacts two opposing surfaces of the second conductive layer. A first via extends into the air gap of the first dielectric layer, wherein the second conductive layer is separated from the first via by a portion of the third dielectric layer that extends from a given surface of the third dielectric layer to the second dielectric layer, and a second via that extends from the given surface of the third dielectric layer to the second conductive layer.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: May 21, 2019
    Assignee: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventor: Thomas J. Knight
  • Patent number: 10119127
    Abstract: Glutamine phenylpyruvate transaminase (GPT) proteins, nucleic acid molecules encoding GPT proteins, and uses thereof are disclosed. Provided herein are various GPT proteins and GPT gene coding sequences isolated from a number of plant species. As disclosed herein, GPT proteins share remarkable structural similarity within plant species, and are active in catalyzing the synthesis of 2-hydroxy-5-oxoproline (2-oxoglutaramate), a powerful signal metabolite which regulates the function of a large number of genes involved in the photosynthesis apparatus, carbon fixation and nitrogen metabolism.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: November 6, 2018
    Assignees: Los Alamos National Security, LLC, University of Maine System Board of Trustees
    Inventors: Pat J Unkefer, Penelope S Anderson, Thomas J Knight
  • Patent number: 9862964
    Abstract: The invention relates to transgenic plants exhibiting dramatically enhanced growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, more efficient nitrogen utilization, increased tolerance to high salt conditions, and increased biomass yields. In one embodiment, transgenic plants engineered to over-express both glutamine phenylpyruvate transaminase (GPT) and glutamine synthetase (GS) are provided. The GPT+GS double-transgenic plants of the invention consistently exhibit enhanced growth characteristics, with T0 generation lines showing an increase in biomass over wild type counterparts of between 50% and 300%. Generations that result from sexual crosses and/or selfing typically perform even better, with some of the double-transgenic plants achieving an astounding four-fold biomass increase over wild type plants.
    Type: Grant
    Filed: September 5, 2016
    Date of Patent: January 9, 2018
    Assignees: Los Alamos National Security, LLC, University of Maine System Board of Trustees
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Publication number: 20170121728
    Abstract: The invention relates to transgenic plants exhibiting enhanced growth rates, seed and fruit yields, and overall biomass yields, as well as methods for generating growth-enhanced transgenic plants. In one embodiment, transgenic plants engineered to over-express glutamine phenylpyruvate transaminase (GPT) are provided.
    Type: Application
    Filed: August 10, 2016
    Publication date: May 4, 2017
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Publication number: 20170051301
    Abstract: The invention relates to transgenic plants exhibiting dramatically enhanced growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, more efficient nitrogen utilization, increased tolerance to high salt conditions, and increased biomass yields. In one embodiment, transgenic plants engineered to over-express both glutamine phenylpyruvate transaminase (GPT) and glutamine synthetase (GS) are provided. The GPT+GS double-transgenic plants of the invention consistently exhibit enhanced growth characteristics, with T0 generation lines showing an increase in biomass over wild type counterparts of between 50% and 300%. Generations that result from sexual crosses and/or selfing typically perform even better, with some of the double-transgenic plants achieving an astounding four-fold biomass increase over wild type plants.
    Type: Application
    Filed: September 5, 2016
    Publication date: February 23, 2017
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Publication number: 20160289648
    Abstract: Glutamine phenylpyruvate transaminase (GPT) proteins, nucleic acid molecules encoding GPT proteins, and uses thereof are disclosed. Provided herein are various GPT proteins and GPT gene coding sequences isolated from a number of plant species. As disclosed herein, GPT proteins share remarkable structural similarity within plant species, and are active in catalyzing the synthesis of 2-hydroxy-5-oxoproline (2-oxoglutaramate), a powerful signal metabolite which regulates the function of a large number of genes involved in the photosynthesis apparatus, carbon fixation and nitrogen metabolism.
    Type: Application
    Filed: March 8, 2016
    Publication date: October 6, 2016
    Inventors: Pat J Unkefer, Penelope S Anderson, Thomas J Knight
  • Publication number: 20160293520
    Abstract: A method is provided of forming an interconnect structure. The method comprises forming a first dielectric layer overlying a first conductive layer, etching a trench opening in the first dielectric layer, depositing a sacrificial material layer in the trench opening, and forming a second conductive layer overlying the sacrificial layer. The method also comprises forming a via to the sacrificial layer, and performing an etch to remove the sacrificial material layer through the via and leave a resultant air gap between the first conductive layer and the second conductive layer increasing the effective dielectric constant between the first and second conductive layers.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 6, 2016
    Applicant: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventor: THOMAS J. KNIGHT
  • Patent number: 9434956
    Abstract: The invention relates to transgenic plants exhibiting dramatically enhanced growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, more efficient nitrogen utilization, increased tolerance to high salt conditions, and increased biomass yields. In one embodiment, transgenic plants engineered to over-express both glutamine phenylpyruvate transaminase (GPT) and glutamine synthetase (GS) are provided. The GPT+GS double-transgenic plants of the invention consistently exhibit enhanced growth characteristics, with T0 generation lines showing an increase in biomass over wild type counterparts of between 50% and 300%. Generations that result from sexual crosses and/or selfing typically perform even better, with some of the double-transgenic plants achieving an astounding four-fold biomass increase over wild type plants.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: September 6, 2016
    Assignees: LOS ALAMOS NATIONAL SECURITY, LLC, UNIVERSITY OF MAINE SYSTEM BOARD OF TRUSTEES
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Patent number: 9385068
    Abstract: A method is provided of forming an interconnect structure. The method comprises forming a first dielectric layer overlying a first conductive layer, etching a trench opening in the first dielectric layer, depositing a sacrificial material layer in the trench opening, and forming a second conductive layer overlying the sacrificial layer. The method also comprises forming a via to the sacrificial layer, and performing an etch to remove the sacrificial material layer through the via and leave a resultant air gap between the first conductive layer and the second conductive layer decreasing the effective dielectric constant between the first and second conductive layers.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: July 5, 2016
    Assignee: Northrop Grumman Systems Corporation
    Inventor: Thomas J. Knight
  • Publication number: 20160137972
    Abstract: The present disclosure relates to transgenic algae having increased growth characteristics, and methods of increasing growth characteristics of algae.
    Type: Application
    Filed: October 16, 2014
    Publication date: May 19, 2016
    Inventors: Pat J. UNKEFER, Penelope S. ANDERSON, Thomas J. KNIGHT
  • Patent number: 9296998
    Abstract: Glutamine phenylpyruvate transaminase (GPT) proteins, nucleic acid molecules encoding GPT proteins, and uses thereof are disclosed. Provided herein are various GPT proteins and GPT gene coding sequences isolated from a number of plant species. As disclosed herein, GPT proteins share remarkable structural similarity within plant species, and are active in catalyzing the synthesis of 2-hydroxy-5-oxoproline (2-oxoglutaramate), a powerful signal metabolite which regulates the function of a large number of genes involved in the photosynthesis apparatus, carbon fixation and nitrogen metabolism.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: March 29, 2016
    Assignees: Los Alamos National Security, LLC, University of Maine System Board of Trustees
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Publication number: 20160068854
    Abstract: The present disclosure relates to compositions and methods for increasing the leaf-to-root ratio of the signal metabolite 2-oxoglutaramate and related proline molecules in plants by modulating levels of ?-amidase to increase nitrogen use efficiency, resulting in enhanced growth, faster growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, increased tolerance to high salt conditions, and increased biomass yields.
    Type: Application
    Filed: June 19, 2015
    Publication date: March 10, 2016
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Patent number: 9252182
    Abstract: Photo-conducting infrared sensors are provided including a substrate (e.g., silicon) with one or more trenches formed on a first surface. An infrared-reflective film can be deposited directly or indirectly onto and conforming in shape with the first surface of the substrate. A lead chalcogenide film can be deposited directly or indirectly over the top of the infrared-reflective film and conforming in shape with the first surface of the substrate. Accordingly, the infrared-reflective film is directly or indirectly sandwiched between the substrate and the lead chalcogenide film.
    Type: Grant
    Filed: September 5, 2012
    Date of Patent: February 2, 2016
    Assignee: Northrop Grumman Systems Corporation
    Inventors: Thomas J. Knight, Christopher F. Kirby
  • Publication number: 20150255375
    Abstract: A method is provided of forming an interconnect structure. The method comprises forming a first dielectric layer overlying a first conductive layer, etching a trench opening in the first dielectric layer, depositing a sacrificial material layer in the trench opening, and forming a second conductive layer overlying the sacrificial layer. The method also comprises forming a via to the sacrificial layer, and performing an etch to remove the sacrificial material layer through the via and leave a resultant air gap between the first conductive layer and the second conductive layer increasing the effective dielectric constant between the first and second conductive layers.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 10, 2015
    Applicant: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventor: THOMAS J. KNIGHT
  • Patent number: 9068194
    Abstract: The present disclosure relates to compositions and methods for increasing the leaf-to-root ratio of the signal metabolite 2-oxoglutaramate and related proline molecules in plants by modulating levels of ?-amidase to increase nitrogen use efficiency, resulting in enhanced growth, faster growth rates, greater seed and fruit/pod yields, earlier and more productive flowering, increased tolerance to high salt conditions, and increased biomass yields.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: June 30, 2015
    Assignees: Los Alamos National Security, LLC, University of Maine System Board of Trustees
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Patent number: 8865451
    Abstract: The present disclosure relates to transgenic algae having increased growth characteristics, and methods of increasing growth characteristics of algae. In particular, the disclosure relates to transgenic algae comprising a glutamine phenylpyruvate transaminase transgene and to transgenic algae comprising a glutamine phenylpyruvate transaminase transgene and a glutamine synthetase.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: October 21, 2014
    Assignees: Los Alamos National Security, LLC, University of Maine System Board of Trustees
    Inventors: Pat J. Unkefer, Penelope S. Anderson, Thomas J. Knight
  • Patent number: 8802595
    Abstract: The present invention describes a composition including a mixture of L- and D-pyroglutamate stereoisomers in a ratio of L to D of from about 80:20 to about 97:3 , and, a carrier medium for application of the L- and D-pyroglutamate stereoisomers to a target plant. The composition can also be used as a germination medium and may be incorporated into a seed coat for assisting in germination. The present invention further describes a method of increasing the agronomic performance of a target plant by treating a target plant with a composition including a mixture of L- and D-pyroglutamate stereoisomers in a ratio of L to D of from about 80:20 to about 97:3 and a carrier medium for said L- and D-pyroglutamate stereoisomers.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: August 12, 2014
    Assignee: Los Alamos National Security, LLC
    Inventors: Pat J. Unkefer, Rodolfo A. Martinez, Thomas J. Knight
  • Publication number: 20140061833
    Abstract: Photo-conducting infrared sensors are provided including a substrate (e.g., silicon) with one or more trenches formed on a first surface. An infrared-reflective film can be deposited directly or indirectly onto and conforming in shape with the first surface of the substrate. A lead chalcogenide film can be deposited directly or indirectly over the top of the infrared-reflective film and conforming in shape with the first surface of the substrate. Accordingly, the infrared-reflective film is directly or indirectly sandwiched between the substrate and the lead chalcogenide film.
    Type: Application
    Filed: September 5, 2012
    Publication date: March 6, 2014
    Applicant: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventors: Thomas J. Knight, Christopher F. Kirby