Patents by Inventor Thomas J. Koob

Thomas J. Koob has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12208180
    Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: January 28, 2025
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Robert Tofe, Elizabeth Chen
  • Patent number: 12076348
    Abstract: Provided herein are micronized placental compositions composed of micronized placental tissue component, such as amnion or chorion and/or filler bound to one or more chelating agents, which in turn are optionally bound, reversibly, to pharmacologically active metal ions. Further provided are methods of making and using the placental compositions. The compositions have numerous therapeutic applications.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 3, 2024
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Patent number: 12070528
    Abstract: Described herein are compositions of collagen and micronized placental tissue components, methods for producing the same and methods for using the same for wound healing, repairing damaged tendons, cosmetic applications and covering biocompatible materials and/or devices.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: August 27, 2024
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Michelle Massee
  • Patent number: 11865142
    Abstract: The present disclosure provides compositions composed of amniotic fluid and/or modified amniotic fluid, a pharmaceutically acceptable carrier, and optionally a placental tissue graft, micronized placental tissue components, or extracts derived therefrom. Also described are systems and apparatuses for administering or storing said compositions, as well as methods of treatment using said compositions.
    Type: Grant
    Filed: May 27, 2021
    Date of Patent: January 9, 2024
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Michelle Massee
  • Publication number: 20230347015
    Abstract: A dehydrated, partially perforated, placental tissue allograft that can be used in the treatment of wounds. Specifically, the dehydrated, partially perforated placental allograft has the property of being able to be cleaned during processing without disrupting the grafts structural integrity or decreasing the concentration of growth factors found within the finished graft. The dehydrated, partially perforated, placental tissue allograft is reconstituted prior to applying it to the subject and is substantially free of undesirable maternal blood contaminants.
    Type: Application
    Filed: April 5, 2023
    Publication date: November 2, 2023
    Inventors: Thomas J. Koob, Michelle Massee, Divya Sukumar
  • Patent number: 11690896
    Abstract: Described herewith are compositions comprising placental growth factors and methods for non-surgical, localized delivery thereof. The composition is delivered to a diseased or injured organ and/or body part and is formulated in a manner which allows for localized retention of the composition at the site of delivery.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: July 4, 2023
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Rebeccah J. C. Brown
  • Patent number: 11648281
    Abstract: Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: May 16, 2023
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Hubbard Frank Burrows, III
  • Patent number: 11607430
    Abstract: Described herein are dehydrated, laminated tissue grafts composed of two or more membrane layers of an amnion membrane, a chorion membrane, a Wharton's jelly, or an intermediate tissue layer, where a layer of micronized placental tissue is interposed between two of the layers. Also described herein are methods for making and using the laminated tissue grafts.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: March 21, 2023
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, John Daniel, Randall Spencer
  • Patent number: 11589973
    Abstract: Implantable medical constructs formed by winding using winding support structures that can be flexible and can be integrated into the medical construct with biocompatible fiber(s) and/or yarn(s) and at least one continuous length collagen fiber. The implantable medical construct can include open suture anchor apertures formed using posts during a winding sequence.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: February 28, 2023
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Patent number: 11583609
    Abstract: The present disclosure describes a medical construct. The medical construct includes a first layer comprising an array of collagen fibers, the first layer forming a core of the medical construct, and a second layer comprising a plurality of braided collagen fibers, wherein the second layer surrounds the core of the medical construct. In some embodiments, the medical construct may further include a third layer comprising a plurality of braided collagen fibers, wherein the third layer surrounds the second layer. Methods of manufacturing a medical construct also provided.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: February 21, 2023
    Assignee: MiMedx Group, Inc.
    Inventors: Chen-rei Wan, Thomas J. Koob, Kirk Joseph Naizer
  • Patent number: 11497791
    Abstract: Described herein are compositions and methods of using placental stem cell recruiting factors, more specifically, isolated placental stem cell recruiting factors. In one embodiment, isolated placental stem cell recruiting factors are delivered to a site such as a diseased or injured organ and/or body part in an amount sufficient to recruit stem cells to the site.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: November 15, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Rebeccah J. C. Brown
  • Patent number: 11389565
    Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: July 19, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Guilhem Denoziere, Rebeccah J. C. Brown
  • Patent number: 11338063
    Abstract: Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in wound healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of chorion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 24, 2022
    Assignee: MiMedx Group, Inc.
    Inventors: John Daniel, Randall Spencer, Brenda Morse, Thomas J. Koob, Somaly Sith
  • Publication number: 20220133955
    Abstract: A meshed, dehydrated, placental tissue allograft that can be used in the treatment of wounds. Specifically, the meshed allograft has the property of being able to be expanded to cover an irregularly shaped wound, therefore reducing the need to apply multiple, uniform sized grafts to a single wound site. The meshed, dehydrated placental tissue allograft is sourced from a human donor, and is then processed to remove any potential contaminants or microbes prior to applying a specific mesh pattern to the tissue. The meshed, dehydrated, placental tissue graft is reconstituted prior to applying to the subject, and can then be configured to optimally cover the shape of the wound site.
    Type: Application
    Filed: November 4, 2021
    Publication date: May 5, 2022
    Inventors: Adam McQueen, Rick LeVaughn, Thomas J. Koob, Michelle Massee
  • Publication number: 20210393852
    Abstract: A meshed, dehydrated, umbilical tissue allograft that can be used in the treatment of wounds. Specifically, the meshed allograft has the property of being able to be expanded to cover an irregularly shaped wound, therefore reducing the need to apply multiple, uniform sized grafts to a single wound site. The meshed, dehydrated umbilical tissue allograft is sourced from a human donor, and is then processed to remove any potential contaminants or microbes prior to applying a specific mesh pattern to the tissue. The meshed, dehydrated, umbilical tissue graft is reconstituted prior to applying to the subject, and can then be configured to optimally cover the shape of the wound site.
    Type: Application
    Filed: June 17, 2021
    Publication date: December 23, 2021
    Inventors: Adam McQueen, Rick LeVaughn, Thomas J. Koob, Michelle Massee
  • Publication number: 20210283190
    Abstract: The present disclosure provides compositions composed of amniotic fluid and/or modified amniotic fluid, a pharmaceutically acceptable carrier, and optionally a placental tissue graft, micronized placental tissue components, or extracts derived therefrom. Also described are systems and apparatuses for administering or storing said compositions, as well as methods of treatment using said compositions.
    Type: Application
    Filed: May 27, 2021
    Publication date: September 16, 2021
    Inventors: Thomas J. Koob, Michelle Massee
  • Publication number: 20210177910
    Abstract: Disclosed herewith is a method for inducing angiogenesis using modified placental tissue or an extract thereof to treat conditions other than cardiovascular conditions.
    Type: Application
    Filed: October 13, 2020
    Publication date: June 17, 2021
    Applicant: MIMEDX GROUP, INC.
    Inventor: Thomas J. Koob
  • Publication number: 20210146011
    Abstract: Described herein are tissue grafts derived from the placental tissue that are reinforced with at least one biocompatible mesh. The tissue grafts possess good adhesion to biological tissues and are useful in wound healing applications. Also described herein are methods for making and using the tissue grafts.
    Type: Application
    Filed: December 4, 2020
    Publication date: May 20, 2021
    Inventors: Thomas J. Koob, Robert Tofe, Elizabeth Chen
  • Patent number: 11000553
    Abstract: Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: May 11, 2021
    Assignee: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Hubbard Frank Burrows, III
  • Publication number: 20210128637
    Abstract: Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
    Type: Application
    Filed: January 15, 2021
    Publication date: May 6, 2021
    Applicant: MiMedx Group, Inc.
    Inventors: Thomas J. Koob, Hubbard Frank Burrows, III