Patents by Inventor Thomas J. Kress

Thomas J. Kress has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Separation of 5-nitroquinoline and 8-nitroquinoline
    Patent number: 6268500
    Abstract: The present invention relates to a process for preparing 5-nitroquinoline hydrohalide comprising: (A) heating a slurry comprising a mixture of nitroquinoline position isomer hydrohalide salts in wet dimethylformamide to form a solution; (B) cooling the solution of Step (A) until a precipitate comprising 5-nitroquinoline hydrohalide is formed; and (C) collecting the precipitate.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: July 31, 2001
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, James P. Wepsiec
  • 5.alpha.-reductase inhibitors
    Patent number: 6150375
    Abstract: A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5.alpha.-reductase.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: November 21, 2000
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, Loretta A. McQuaid, Blake L. Neubauer, Vincent P. Rocco, Kevin L. Haehl, Thomas J. Kress, James P. Wepsiec
  • Process for preparation of benzo[f]quinolinones
    Patent number: 5578724
    Abstract: A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5.alpha.-reductase and their preparation is disclosed.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: November 26, 1996
    Assignee: Eli Lilly and Company
    Inventors: Kevin L. Haehl, Thomas J. Kress, James P. Wepsiec
  • Intermediates to 4-amino- hexahydrobenz (cd) indoles and processes therefor
    Patent number: 5559245
    Abstract: New intermediates, and processes therefor, provide an efficient method for deriving 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indoles, which are themselves intermediates to useful CNS agents, from the Kornfeld-Woodward ketone and like compounds. Preferred embodiments provide means for the preparation of substantially pure enantiomers of the desired 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indole.
    Type: Grant
    Filed: September 12, 1995
    Date of Patent: September 24, 1996
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, M. Robert Leanna, Michael J. Martinelli, Barry C. Peterson
  • Crystalline salt of 4-(di-N-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]-indole
    Patent number: 5397799
    Abstract: Crystalline 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole hippurate and its method of preparation and use are provided.
    Type: Grant
    Filed: May 19, 1993
    Date of Patent: March 14, 1995
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, David L. Varie
  • Intermediates to 4-amino-hexahydrobenz[cd]indoles and processes therefor
    Patent number: 5212319
    Abstract: New intermediates, and processes therefor, provide an efficient method for deriving 4-amino-1,2,-2a,3,4,5-hexahydrobenz[cd]indoles, which are themselves intermediates to useful CNS agents, from the Kornfeld-Woodward ketone and like compounds. Preferred embodiments provide means for the preparation of substantially pure enantiomers of the desired 4-amino-1,2,2a,3,4,5-hexahydrobenz[cd]indole.
    Type: Grant
    Filed: November 26, 1991
    Date of Patent: May 18, 1993
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, M. Robert Leanna, Michael J. Martinelli, Barry C. Peterson
  • 4-amino-6-iodo-hexahydrobenz(cd)indoles
    Patent number: 5039820
    Abstract: 4-Amino-6-iodo-1,2,2a,3,4,5-hexahydrobenz[ cd]indoles are useful intermediates to 4-amino-1,3,4,5-tetrahydrobenz [cd]indoles containing aminocarbonyl or alkoxycarbonyl substituents in the 6-position which are useful for the treatment of various disorders of the central nervous system.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: August 13, 1991
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, James P. Wepsiec
  • Process for preparing 5-halopyrimidines
    Patent number: 4252955
    Abstract: The reaction of formamide at high temperature with a 4-halo-5-hydroxy-2(5H)-furanone provides high yields of 5-chloro or 5-bromopyrimidines.
    Type: Grant
    Filed: November 2, 1979
    Date of Patent: February 24, 1981
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, Edward F. Szymanski
  • Process for preparing 2-amino-5-chloropyridine
    Patent number: 3985759
    Abstract: 2-Amino-5-chloropyridine is prepared by chlorinating 2-aminopyridine in a strongly acidic medium. 2-Amino-5-chloropyridine is a useful intermediate in the preparation of chloro-substituted-imidazo-pyridine herbicides.
    Type: Grant
    Filed: June 7, 1974
    Date of Patent: October 12, 1976
    Assignee: Eli Lilly and Company
    Inventors: Thomas J. Kress, Larry L. Moore
  • Process for bromination of pyrimidine
    Patent number: 3956301
    Abstract: The process for brominating pyrimidine which comprises reacting bromine at an elevated temperature with the hydrogen halide addition salt of pyrimidine in an organic solvent substantially inert to the action of bromine under the conditions of the process. The process is also shown to be applicable to other nitrogen-containing heterocycles.
    Type: Grant
    Filed: March 24, 1975
    Date of Patent: May 11, 1976
    Assignee: Eli Lilly and Company
    Inventor: Thomas J. Kress