Abstract: This disclosure provides therapeutic methods for treating cancer including combination therapy with a multimeric anti-DR5 antibody and a cancer therapy, e.g., radiation, an anthracycline, a folic acid analog, a platinum-based agent, a taxane, a topoisomerase II inhibitor, a SMAC mimetic, a vinca alkaloid, a Brutons tyrosine kinase (BTK) inhibitor, a phosphoinositide 3-kinase delta (PI3K?) inhibitor, a myeloid cell leukemia-1 (Mcl-1) inhibitor, or any combination thereof.

Abstract: Systems and methods for awarding bonuses associated with gaming machines are disclosed. A bonus system host generates and transmits bonus event information to a gaming machine for display. The bonus system can be associated with a player tracking network including a remote player tracking host and a player tracking device at a gaming machine, which can include a controller and display. Alternatively, no player tracking device exists at the gaming machine, and bonus information is sent to a display on the gaming machine itself. A bonus can be awarded independent of the outcome of play on the gaming machine, and can be a themed bonus. Bonus event results for a specific player can be carried over to a following instance of a game played by that specific player. One form of bonus can be improved pay tables, with odds calculated as a function of player play within the bonus system.

Abstract: A system includes a compressor temperature sensor that generates a compressor discharge temperature signal corresponding to a compressor of a refrigeration system, a compressor pressure sensor that generates a compressor discharge pressure signal corresponding to the compressor, and a controller processing the signals over a predetermined time period. The processing includes calculating a discharge saturation temperature based on the compressor discharge pressure signal, calculating compressor superheat data based on the compressor discharge temperature signal and the discharge saturation temperature, accumulating the compressor superheat data over the predetermined time period, and comparing the accumulated compressor superheat data to a predetermined threshold. The controller generates an alarm indicating a compressor fault based on the comparing.

Abstract: Some implementations of the invention allow patrons to earn a “collectible” during the course of playing a wagering game. A collectible (and/or a hierarchy of collectibles) may be associated with a particular casino. While playing a game, a player may have options to redeem one or more collectibles. In some such implementations, a collectible may activate special game features, such as a special bonus round, a higher paytable for a defined period of time, or other features described in detail herein. A collectible may persist after a gaming session is completed. Some implementations of the invention provide persistent collectibles only for patrons who are members of a player loyalty program. However, other implementations of the invention provide persistent collectibles even for patrons who are not members of a player loyalty program.

Abstract: An electronic game including at least one display exhibiting a plurality of windows or segments each displaying a different subject matter is disclosed. The different subject matter in each of the plurality of windows preferably includes a real time promotional points total, an awards display, a sponsor advertising material display, an Internet display and an electronic game. The electronic game, which may include a wagering game, may be played by tendering money or tendering promotional points instead of money. Promotional points may be awarded instead of a portion of a money award, or supplemental to it. Promotional points may be accumulated by players through both gaming and non-gaming activities, including activities not involving a commercial transaction. An electronic gaming apparatus is described which also serves as an Internet portal.

Abstract: This invention relates to human immunodeficiency virus (HIV) protein fragments which have antiviral activity, and particularly relates to HIV peptides derived from the HIV transmembrane glycoprotein (gp41) which inhibit HIV-induced cell-cell fusion. This invention further relates to methods for the inhibition of enveloped viral infection, and to methods that modulate biochemical processes which involve coiled coil peptide interactions.

Abstract: This invention relates to human immunodeficiency virus (HIV) protein fragments which have antiviral activity, and particularly relates to HIV peptides derived from the HIV transmembrane glycoprotein (gp41) which inhibit HIV-induced cell-cell fusion. This invention further relates to methods for the inhibition of enveloped viral infection, and to methods that modulate biochemical processes which involve coiled coil peptide interactions.

Abstract: An electronic game including at least one display exhibiting a plurality of windows or segments each displaying a different subject matter is disclosed. The different subject matter in each of the plurality of windows preferably includes a real time promotional points total, an awards display, a sponsor advertising material display, an Internet display and an electronic game. The electronic game, which may include a wagering game, may be played by tendering money or tendering promotional points instead of money. Promotional points may be awarded instead of a portion of a money award, or supplemental to it. Promotional points may be accumulated by players through both gaming and non-gaming activities, including activities not involving a commercial transaction. An electronic gaming apparatus is described which also serves as an Internet portal.

Abstract: Native and recombinant peptides which elicit anti-HIV immune response are provided.

Abstract: This invention relates to human immunodeficiency virus (HIV) protein fragments which have antiviral activity, and particularly relates to HIV peptides derived from the HIV transmembrane glycoprotein (gp41) which inhibit HIV-induced cell-cell fusion. This invention further relates to methods for the inhibition of enveloped viral infection, and to methods that modulate biochemical processes which involve coiled coil peptide interactions.

Abstract: The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID:1) ptides corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.