Patents by Inventor Thomas J. McMurry

Thomas J. McMurry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-based multimeric targeted contrast agents
    Patent number: 6991775
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: January 31, 2006
    Assignee: Epix Medical, Inc.
    Inventors: Steffi K. Koerner, Andrew Kolodziej, Thomas J. McMurry, Shrikumar Nair, Alexander L. Nivorozhkin, Wei-Chuan Sun, Xifang Wang
  • Polypeptide conjugates with extended circulating half-lives
    Publication number: 20040254119
    Abstract: The present invention relates to compounds and methods for synthesizing compounds wherein the compounds exhibit extended circulating half-life in the blood. The increase in circulating half-life is achieved by conjugating polypeptides to binding groups that exhibit high affinity for human serum albumin.
    Type: Application
    Filed: July 15, 2004
    Publication date: December 16, 2004
    Inventors: Theodore R. West, Thomas J McMurry, Stephane Dumas, Andrew Kolodziej
  • Diagnostic imaging contrast agents with extended blood retention
    Publication number: 20040208827
    Abstract: The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
    Type: Application
    Filed: January 12, 2004
    Publication date: October 21, 2004
    Applicant: Epix Medical, Inc., a Delaware corporation
    Inventors: Thomas J. McMurry, Hironao Sijiki, Daniel M. Scott, Randall B. Lauffer
  • Diagnostic imaging contrast agents with extended blood retention
    Publication number: 20040202613
    Abstract: The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
    Type: Application
    Filed: January 12, 2004
    Publication date: October 14, 2004
    Applicant: Epix Medical, Inc., a Delaware corporation
    Inventors: Thomas J. McMurry, Hironao Sijiki, Daniel M. Scott, Randall B. Lauffer
  • Bioactivated diagnostic imaging constrast agents
    Publication number: 20040156785
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bioactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Application
    Filed: January 16, 2004
    Publication date: August 12, 2004
    Applicant: Epix Medical , Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stephane Dumas
  • Bioactivated diagnostic imaging contrast agents
    Patent number: 6709646
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Grant
    Filed: September 14, 2001
    Date of Patent: March 23, 2004
    Assignee: Epix Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stéphane Dumas
  • Diagnostic imaging contrast agents with extended blood retention
    Patent number: 6676929
    Abstract: The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
    Type: Grant
    Filed: December 20, 2001
    Date of Patent: January 13, 2004
    Assignee: Epix Medical, Inc.
    Inventors: Thomas J. McMurry, Hironao Sijiki, Daniel M. Scott, Randall B. Lauffer
  • Targeting multimeric imaging agents through multilocus binding
    Publication number: 20040005274
    Abstract: The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites.
    Type: Application
    Filed: May 27, 2003
    Publication date: January 8, 2004
    Applicant: Epix Medical, Inc., a Delaware corporation
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephane Dumas, Andrew Kolodziej, John C. Amedio, Peter D. Caravan, Zhaoda Zhang, Shrikumar Nair, Robert M. Weisskoff
  • Targeting multimeric imaging agents through multilocus binding
    Patent number: 6652835
    Abstract: The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites. The compounds consist of: a) two or more Image Enhancing Moieties (IEMs) (or signal-generating moiety) comprising multiple subunits; b) two or more Target Binding Moieties (TBMs), providing for in vivo localization and multimer rigidification; and c) a scaffold framework for attachment of the above moieties. d) optional linkers for attachment of the IEMs to scaffold. This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement of diagnostic imaging.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: November 25, 2003
    Assignee: Epix Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephane Dumas, Andrew Kolodziej, John Amedio, Peter Caravan, Zhaoda Zhang
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20030216320
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: July 30, 2002
    Publication date: November 20, 2003
    Inventors: Steffi K. Koerner, Andrew Kolodziej, Thomas J. McMurry, Shrikumar Nair, Alexander L. Nivorozhkin, Wei-Chuan Sun, Xifang Wang
  • Diagnostic imaging contrast agents with extended blood retention
    Publication number: 20030180223
    Abstract: The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
    Type: Application
    Filed: January 30, 2003
    Publication date: September 25, 2003
    Inventors: Thomas J. McMurry, Hironao Sijiki, Daniel M. Scott, Randall B. Lauffer
  • Peptide-based multimeric targeted contrast agents
    Publication number: 20030180222
    Abstract: Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
    Type: Application
    Filed: July 30, 2002
    Publication date: September 25, 2003
    Inventors: Zhaoda Zhang, John C. Amedio, Peter D. Caravan, Stephane Dumas, Andrew Kolodziej, Thomas J. McMurry
  • Magnetic resonance imaging using contrast agents bioactivated by enzymatic cleavage
    Publication number: 20030082106
    Abstract: The present invention relates to contrast agents for diagnostic magnetic resonance imaging. In particular, this invention relates to novel compounds which exhibit surprisingly improved relaxivity due to improved binding of an amino acid targeting group within the molecules to proteins following specific cleavage of the agent by a peptidase. This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement during magnetic resonance imaging.
    Type: Application
    Filed: July 19, 2002
    Publication date: May 1, 2003
    Inventors: Aleksandr Nivorozhkin, Thomas J. McMurry, Andrew Kolodziej
  • Diagnostic imaging contrast agents with extended blood retention
    Publication number: 20020164289
    Abstract: The present invention relates to contrast agents for diagnostic imaging with prolonged blood retention. In particular, this invention relates to novel compounds that are characterized by an image enhancing moiety (IEM); a protein plasma binding moiety (PPBM); and a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging.
    Type: Application
    Filed: December 20, 2001
    Publication date: November 7, 2002
    Inventors: Thomas J. McMurry, Hironao Sijiki, Daniel M. Scott, Randall B. Lauffer
  • Bioactivated diagnostic imaging contrast agents
    Publication number: 20020034476
    Abstract: The present invention relates to improved diagnostic agents for Magnetic Resonance Imaging and optical imaging. In particular, this invention relates to MRI and optical imaging agents that allow for the sensitive detection of a specific bloactivity within a tissue. These agents are prodrug contrast agents which are bioactivated in vivo in the presence of the specific bioactivity. This invention also relates to pharmaceutical compositions comprising these agents and to methods of using the agents and compositions comprising the agents.
    Type: Application
    Filed: September 14, 2001
    Publication date: March 21, 2002
    Applicant: EPIX Medical, Inc.
    Inventors: Randall B. Lauffer, Thomas J. McMurry, Stephen O. Dunham, Daniel M. Scott, David J. Parmelee, Stephane Dumas
  • Template synthesis of macrocyclic catecholamide complexes
    Patent number: 4939254
    Abstract: A method is provided for a high yield template synthesis of macrocyclic catecholamide ligands.
    Type: Grant
    Filed: October 30, 1989
    Date of Patent: July 3, 1990
    Assignee: The Regents of the University of California
    Inventors: Thomas J. McMurry, Kenneth N. Raymond