Abstract: The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist; or the combination of a VISTA agonist and a -1, PD-L1 or POD-L3 agonist which combinations respectively elicit an additive or synergistic effect at promoting T cell immunity or inhibiting T cell immunity, i.e., CD4, CD8 or Th1 immunity. The agonists and antagonists may be in the same or separate compositions and may be administered together or separately administered in either order.

Abstract: An improved electronic controller for the motor of a high-speed spindle attachment used in conjunction with a cnc milling machine. The controller comprises preventative circuitry that protects the spindle assembly of the attachment from overload accruing as a result of relatively moderate increases in torque demand during use. The controller senses the power level being used by the motor while it causes high-speed spindle rotation, and when it identifies a power consumption rate by the spindle that exceeds the operator pre-set maximum level determined to be safe for avoiding catastrophic spindle damage, the electronic controller sends a signal back to the computer controlling the axes of the cnc milling machine that is sufficient to slow, pause, and/or stop the feed-rate.

Abstract: A variable speed milling machine attachment, and a method for its use, that is efficiently configured for minimal reduction of the spindle-to-table distance of a milling machine, such as the well-known Bridgeport miller, and which when attached to a milling machine having a maximum spindle speed of approximately 5,000 rpm, allows an operator to perform high speed milling, grinding, drilling, and engraving functions at selected sustained spindle speeds greater than 5,000 rpm, up to and including sustained spindle speeds in excess of 20,000 rpm. The attachment also has a visual display that provides an operator with indications of actual spindle speed for precise initial selection of the proper spindle speed for an intended machining task.

Abstract: A pavement cleaning vehicle having brushes for dislodging and sweeping rearwardly debris, is provided with elongated air nozzles which direct the debris towards suction heads. The air nozzles extend angularly outward and forward from a location along the center line of the vehicle and have curved end portions which curl inward from the vehicle sides in circular arcs. Suction heads are disposed at the center of the arcs and a suction head is also disposed adjacent to the centrally located nozzle ends.