Abstract: An orthopedic walking boot and method of use for off-loading plantar ulcers is disclosed. The orthopedic walking boot may be particularly effective for off-loading the plantar ulcers of diabetic patients with impeded mobility due to age or illness who cannot be treated with a total contact cast. Embodiments of the orthopedic walking boot presented offer a configurable insole of removable cells seated in a rigid support frame. The cell array may be custom fitted to the size, shape, and location of the patient's planter ulcer.