Patents by Inventor Thomas J. Poteat

Thomas J. Poteat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Islet isolation process
    Patent number: 5322790
    Abstract: A method of producing intact islets of Langerhans in an insulin producing condition uses a mixture of Hank's solution and 10% by volume fetal calf serum to ductally distend the human pancreas. The exocrine tissue of the pancreas is digested at about 37.degree. C. by an enzyme preparation of collagenase, trypsin and proteolytic enzyme present in the mixture at a level of about 0.2% by weight. The digestion is monitored at regular intervals during the process. The digested pancreas is comminuted, filtered and intact islets of Langerhans are recovered. The recovered islets retain their insulin producing properties.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: June 21, 1994
    Assignees: McDonnell Douglas Corporation, Washington University
    Inventors: David W. Scharp, Paul E. Lacy, Edward H. Finke, Thomas J. Poteat
  • Islet isolation process
    Patent number: 4868121
    Abstract: A method of producing intact islets of Langerhans in an insulin producing condition uses a mixture of Hank's solution and 10% by volume fetal calf serum to ductally distend the human pancreas. The exocrine tissue of the pancreas is digested at about 37.degree. C. by an enzyme preparation of collagenase, trypsin and proteolytic enzyme present in the mixture at a level of about 0.2% by weight. The digestion is monitored at regular intervals during the process. The digested pancreas is comminuted, filtered and intact islets of Langerhans are recovered. The recovered islets retain their insulin producing properties.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: September 19, 1989
    Assignees: McDonnell Douglas Corporation, Washington University
    Inventors: David W. Scharp, Paul E. Lacy, Edward H. Finke, Thomas J. Poteat