Patents by Inventor Thomas J. Ruth
Thomas J. Ruth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240011179Abstract: A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging and delivering the target cell apparatus into a target station apparatus; a target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.Type: ApplicationFiled: April 21, 2023Publication date: January 11, 2024Inventors: Paul SCHAFFER, Francois BENARD, Kenneth R. BUCKLEY, Victoire HANEMAAYER, Cornelia Manuela HOEHR, Julius Alexander KLUG, Michael S. KOVACS, Thomas J. MORLEY, Thomas J. RUTH, John VALLIANT, Stefan K. ZEISLER, Maurice G. DODD
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Patent number: 11661668Abstract: A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering the target cell apparatus into a target station apparatus; target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.Type: GrantFiled: June 11, 2021Date of Patent: May 30, 2023Assignee: TRIUMF INC.Inventors: Paul Schaffer, Francois Benard, Kenneth R. Buckley, Victoire Hanemaayer, Cornelia Manuela Hoehr, Julius Alexander Klug, Michael S. Kovacs, Thomas J. Morley, Thomas J. Ruth, John Valliant, Stefan K. Zeisler, Maurice G. Dodd
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Publication number: 20210335515Abstract: A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging, and delivering. the target cell apparatus into a target station apparatus target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus, and (iii) the receiving cell apparatus and the dissolution/purification module.Type: ApplicationFiled: June 11, 2021Publication date: October 28, 2021Inventors: Paul SCHAFFER, Francois BENARD, Kenneth R. BUCKLEY, Victoire HANEMAAYER, Cornelia Hoehr MANUELA, Julius Alexander KLUG, Michael S. KOVACS, Thomas J. MORLEY, Thomas J. RUTH, John VALLIANT, Stefan K. ZEISLER, Maurice G. DODD
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Publication number: 20210027903Abstract: A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging and delivering the target cell apparatus into a target station apparatus; a target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.Type: ApplicationFiled: June 5, 2020Publication date: January 28, 2021Inventors: Paul SCHAFFER, Francois BENARD, Kenneth R. BUCKLEY, Victoire HANEMAAYER, Cornelia Hoehr MANUELA, Julius Alexander KLUG, Michael S. KOVACS, Thomas J. MORLEY, Thomas J. RUTH, John VALLIANT, Stefan K. ZEISLER, Maurice G. DODD
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Publication number: 20190221325Abstract: A process for producing a hardened target plate coated with a molybdenum-100 metal, comprising the steps of: (i) suspending and intermixing a refined molybdenum-100 metal powder having grain sizes of less than about 10 microns, and a binder, in a polar organic solvent; (ii) inserting into the molybdate-100 mixture, a cathode plate comprising a transition metal and an anode plate comprising conductive metal; (iii) applying a potential from about 300 V to about 1,300 V to the anode plate and cathode plate; (iv) recovering the cathode plate from the molybdate-100 mixture; and (v) sintering the cathode plate at a temperature from a range of about 1,200° C. to about 1,900° C. for a period of time from about 3 h to about 8 h.Type: ApplicationFiled: January 21, 2019Publication date: July 18, 2019Inventors: Paul SCHAFFER, Francois BENARD, Kenneth R. BUCKLEY, Victoire HANEMAAYER, Cornelia Hoehr MANUELA, Julius Alexander KLUG, Michael S. KOVACS, Thomas J. MORLEY, Thomas J. RUTH, John VALLIANT, Stefan K. ZEISLER, Maurice G. DODD
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Publication number: 20170271036Abstract: A system for producing technetium-99m from molybdate-100. The system comprises: a target capsule apparatus for housing a Mo-100-coated target plate; a target capsule pickup apparatus for engaging and delivering the target cell apparatus into a target station apparatus; a target station apparatus for receiving and mounting therein the target capsule apparatus. The target station apparatus is engaged with a cyclotron for irradiating the Mo-100-coated target plate with protons. The irradiated target capsule apparatus is transferred to a receiving cell apparatus comprising a dissolution/purification module for receiving therein a proton-irradiated Mo-100-coated target plate. A conveyance conduit infrastructure interconnects: (i) the target capsule pickup apparatus with the target station apparatus, (ii) the target station apparatus and the receiving cell apparatus; and (iii) the receiving cell apparatus and the dissolution/purification module.Type: ApplicationFiled: April 28, 2017Publication date: September 21, 2017Inventors: Paul SCHAFFER, Francois BENARD, Kenneth R. BUCKLEY, Victoire HANEMAAYER, Cornelia Hoehr MANUELA, Julius Alexander KLUG, Michael S. KOVACS, Thomas J. MORLEY, Thomas J. RUTH, John VALLIANT, Stefan K. ZEISLER, Maurice G. DODD
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Patent number: 9587292Abstract: A method of isolating 99Mo produced using a (n,?) reaction according to example embodiments may include vaporizing a source compound containing 98Mo and 99Mo. The vaporized source compound may be ionized to form ions containing 98Mo and 99Mo. The ions may be separated to isolate the ions containing 99Mo. The isolated ions containing 99Mo may be collected with a collector. Accordingly, the isolated 99Mo may have a relatively high specific radioactivity and, in turn, may be used to produce the diagnostic radioisotope, 99mTc, through radioactive decay.Type: GrantFiled: October 1, 2009Date of Patent: March 7, 2017Assignee: Advanced Applied Physics Solutions, Inc.Inventors: Suzanne Lapi, Thomas J. Ruth, Dirk W. Becker, John M. D'Auria
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Patent number: 8211390Abstract: A method of isolating a radioisotope according to example embodiments may include vaporizing a source compound containing a first isotope and a second isotope of an element, wherein the second isotope may have at least one of therapeutic and diagnostic properties when used as a radiopharmaceutical. The vaporized source compound may be ionized to form charged particles of the first and second isotopes. The charged particles may be separated to isolate the particles of the second isotope. The isolated charged particles of the second isotope may be collected with an oppositely-charged collector. Accordingly, the isolated second isotope may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.Type: GrantFiled: February 26, 2010Date of Patent: July 3, 2012Assignee: Advanced Applied Physics Solutions, Inc.Inventors: Suzanne Lapi, Thomas J. Ruth, Dirk W. Becker, John M. D'Auria
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Publication number: 20110079108Abstract: A method of isolating 99Mo produced using a (n,?) reaction according to example embodiments may include vaporizing a source compound containing 98Mo and 99Mo. The vaporized source compound may be ionized to form ions containing 98Mo and 99Mo. The ions may be separated to isolate the ions containing 99Mo. The isolated ions containing 99Mo may be collected with a collector. Accordingly, the isolated 99Mo may have a relatively high specific radioactivity and, in turn, may be used to produce the diagnostic radioisotope, 99mTc, through radioactive decay.Type: ApplicationFiled: October 1, 2009Publication date: April 7, 2011Inventors: Suzanne Lapi, Thomas J. Ruth, Dirk W. Becker, John M. D'Auria
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Publication number: 20100160614Abstract: A method of isolating a radioisotope according to example embodiments may include vaporizing a source compound containing a first isotope and a second isotope of an element, wherein the second isotope may have at least one of therapeutic and diagnostic properties when used as a radiopharmaceutical. The vaporized source compound may be ionized to form charged particles of the first and second isotopes. The charged particles may be separated to isolate the particles of the second isotope. The isolated charged particles of the second isotope may be collected with an oppositely-charged collector. Accordingly, the isolated second isotope may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.Type: ApplicationFiled: February 26, 2010Publication date: June 24, 2010Inventors: Suzanne Lapi, Thomas J. Ruth, Dirk W. Becker, John M. D'Auria
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Patent number: 7708961Abstract: A method of isolating 186Re according to example embodiments may include vaporizing a source compound containing 185Re and 186Re. The vaporized source compound may be ionized to form negatively-charged molecules containing 185Re and 186Re. The negatively-charged molecules may be separated to isolate the negatively-charged molecules containing 186Re. The isolated negatively-charged molecules containing 186Re may be collected with a positively-charged collector. Accordingly, the isolated 186Re may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.Type: GrantFiled: March 31, 2008Date of Patent: May 4, 2010Assignee: Advanced Applied Physics Solutions, Inc.Inventors: Suzanne Lapi, Thomas J. Ruth, Dirk W. Becker, John M. D'Auria
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Publication number: 20080241025Abstract: A method of isolating 186Re according to example embodiments may include vaporizing a source compound containing 185Re and 186Re. The vaporized source compound may be ionized to form negatively-charged molecules containing 185Re and 186Re. The negatively-charged molecules may be separated to isolate the negatively-charged molecules containing 186Re. The isolated negatively-charged molecules containing 186Re may be collected with a positively-charged collector. Accordingly, the isolated 186Re may be used to produce therapeutic and/or diagnostic radiopharmaceuticals having higher specific activity.Type: ApplicationFiled: March 31, 2008Publication date: October 2, 2008Inventors: Suzanne Lapi, Thomas J. Ruth, Dirk W. Becker
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Patent number: 6845137Abstract: A system and method for producing 18F-Fluoride by using a proton beam to irradiate 18Oxygen in gaseous form. The irradiated 18Oxygen is contained in a chamber that includes at least one component to which the produced 18F-Fluoride adheres. A solvent dissolves the produced 18F-Fluoride off of the at least one component while it is in the chamber. The solvent is then processed to obtain the 18F-Fluoride.Type: GrantFiled: February 23, 2001Date of Patent: January 18, 2005Assignee: TriumfInventors: Thomas J. Ruth, Kenneth R. Buckley, Kwonsoo Chun, Salma Jivan, Stefan K. Zeisler
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Publication number: 20010043663Abstract: A system and method for producing 18F-Fluoride by using a proton beam to irradiate 18Oxygen in gaseous form. The irradiated 18Oxygen is contained in a chamber that includes at least one component to which the produced 18F-Fluoride adheres. A solvent dissolves the produced 18F-Fluoride off of the at least one component while it is in the chamber. The solvent is then processed to obtain the 18F-Fluoride.Type: ApplicationFiled: February 23, 2001Publication date: November 22, 2001Inventors: Thomas J. Ruth, Kenneth R. Buckley, Kwonsoo Chun, Salma Jivan, Stefan K. Zeisler