Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: A method of forming a piston ring includes providing a base portion formed of a metallic material, the base portion having a first surface, and a second surface that is opposite the first surface, the base portion configured to interface with a piston ring groove. The method includes grinding the first surface to form a reference surface, applying a chromium layer to the second surface, and grinding the chromium layer to reduce a surface roughness of the chromium layer.

Abstract: Coated microparticles for sustained-release of an active pharmaceutical ingredient after parenteral administration, and methods of producing such coated microparticles, are provided. The coated microparticles comprise core particles of an active pharmaceutical ingredient and a first polymeric coating on the core particles. The first polymeric coating is permeable to the active pharmaceutical ingredient forms a saturated solution within the coated microparticle, resulting in pseudo-zero-sustained release period. A second polymeric coating can be employed to add mechanical support or as a rate-controlling element.

Abstract: A switchable modular jack assembly includes a housing which defines a receptacle for receiving an RJ14 modular plug, and a socket for receiving a pre-wired adapter plug. Each of the RJ14 modular plug and the adapter plug has electrical contacts on an exposed surface thereof. The jack assembly also includes leaf spring electrical contacts which extend into the receptacle and socket. When no RJ14 modular plug is received by the receptacle, the leaf spring electrical contacts contact the electrical contacts of the adapter plug. When an RJ14 modular plug is received by the receptacle, the leaf spring electrical contacts contact the electrical contacts of the RJ14 modular plug, but not the electrical contacts of the adapter plug.

Abstract: Exemplary pistons and methods are disclosed. A method may include depositing a scuff and seizure resistant material via a thermal spray method on the surface of a piston pin bore used in internal combustion engines. Exemplary pistons may have a crown and a skirt. The piston crown may define a combustion bowl and a ring land extending circumferentially around the combustion bowl, the skirt supporting the crown, the skirt including a pair of pin bosses, the pin bosses each defining a pin bore configured to receive a piston pin, each pin bore defining a pin bore surface extending circumferentially about the piston pin bore, the bore surface formed of a first material. The method may further include applying a coating comprising at least a second material different from the first material to the pin bore surfaces using a thermal spray process.

Abstract: Exemplary oil control rings and methods are disclosed. An oil control ring may include an upper lamella having a first outer radial surface and a lower lamella having a second outer radial surface. An expander ring is in communication with the upper lamella and the lower lamella and generates an expander radial outward force on the lamellas. At least one of the first outer radial surface and the second outer radial surface is comprised of a first contact section and a first tapered section. The first tapered section is configured to generate a first radially inward force greater than or equal to the expander radial outward force when moved in a first direction and a second radially inward force less than the expander radial outward force when moved in a second direction.

Abstract: A connecting rod having a small end and a large end, the small end including a pin bore defined by a pin bore surface. A thermal spray coating applied to at least a portion of the pin bore surface and a method of applying the thermal spray coating to the pin bore surface using a thermal spray technique.

Abstract: The present invention provides for a drug delivery device. The device can comprise at least one core with a first active pharmaceutical ingredient (API), coated with a first layer that is permeable or semi-permeable to the API, coated with a second layer that is impermeable to the API, and having a delivery window to allow passage of the API through the device and into body fluids or tissues. The device can also have a wicking material to modify the rate of transport of the API into the body fluid or tissues.

Abstract: Described herein are injectable corticosteroid-loaded microparticles, pharmaceutical composition thereof and methods for reducing inflammation or pain in a body compartment such as a joint, an epidural space, a vitreous body of an eye, a surgically created space, or a space adjacent to an implant.

Abstract: A switchable modular jack assembly includes a housing which defines a receptacle for receiving an RJ14 modular plug, and a socket for receiving a pre-wired adapter plug. Each of the RJ14 modular plug and the adapter plug has electrical contacts on an exposed surface thereof. The jack assembly also includes leaf spring electrical contacts which extend into the receptacle and socket. When no RJ14 modular plug is received by the receptacle, the leaf spring electrical contacts contact the electrical contacts of the adapter plug. When an RJ14 modular plug is received by the receptacle, the leaf spring electrical contacts contact the electrical contacts of the RJ14 modular plug, but not the electrical contacts of the adapter plug.

Abstract: Some embodiments comprise systems, methods, compositions, and apparatus including, but not limited to, thermally sprayed titanium-nitride ceramic particles encapsulated in one of several pure metals or metallic alloys; for producing a high wear-resistant coating on the contacting friction surfaces of machined component parts, including among them, piston rings, piston connecting rods and cylinder liners.

Abstract: A connecting rod having a small end and a large end, the small end including a pin bore defined by a pin bore surface. A thermal spray coating applied to at least a portion of the pin bore surface and a method of applying the thermal spray coating to the pin bore surface using a thermal spray technique.

Abstract: A monolithic high power radio frequency switch includes a substrate, and first and second gallium nitride high electron mobility transistors on the substrate. Each of the first and second gallium nitride high electron mobility transistors includes a respective source, drain and gate terminal. The source terminal of the first gallium nitride high electron mobility transistor is coupled to the drain terminal of the second gallium nitride high electron mobility transistor, and the source terminal of the second gallium nitride high electron mobility transistor is coupled to ground. An RF input pad is coupled to the drain terminal of the first second gallium nitride high electron mobility transistor, an RF output pad is coupled to the source terminal of the first gallium nitride high electron mobility transistor and the drain terminal of the second gallium nitride high electron mobility transistor, and a control pad is coupled to the gate of the first gallium nitride high electron mobility transistor.

Abstract: A piston including a piston crown, the piston crown having a combustion surface that further defines a combustion bowl rim area and a bowl root area. A thermal spray coating is applied to the bowl rim and/or the bowl root area of the piston to increase the resistance of the piston to thermal mechanical fatigue. The thermal spray coating may be metal or alloy based and may be applied using any suitable process.

Abstract: Thermal spray coatings are described herein. The coatings include at least one base material having a thickness. Within at least a portion of the thickness is a dispersion of solid lubricant particles. The thermal spray coatings may be applied to at least a portion of a component that has a mating surface with another component. The mating surface may cause the thermal spray coating to wear down and become thinner. As the coating becomes thinner, particles of solid lubricant entrapped deeper within in the base material become exposed and impart friction reducing properties to the component.

Abstract: The present invention relates generally to peptide vaccines. More specifically, the present invention relates to vaccines against rhinoviruses and other related and non-related pathogenic animal viruses. In addition, the present invention relates generally to methods of designing and producing vaccines against viruses and, in certain embodiments, against rhinoviruses and other pathogenic viruses.

Abstract: The present invention relates generally to peptide vaccines. More specifically, the present invention relates to vaccines against rhinoviruses and other related and non-related pathogenic animal viruses. In addition, the present invention relates generally to methods of designing and producing vaccines against viruses and, in certain embodiments, against rhinoviruses and other pathogenic viruses.

Abstract: A diode structure having a reduced on-resistance in the forward-biased condition includes semiconductor layers, preferably of silicon carbide. The anode and cathode of the device are located on the same side of the bottom semiconductor layer, providing lateral conduction across the diode body. The anode is positioned on a semiconductor mesa, and the sides of the mesa are covered with a nonconductive spacer extending from the anode to the bottom layer. An ohmic contact, preferably a metal silicide, covers the surface of the bottom layer between the spacer material and the cathode. The conductive path extends from anode to cathode through the body of the mesa and across the bottom semiconductor layer, including the ohmic contact. The method of forming the diode includes reacting layers of silicon and metal on the appropriate regions of the diode to form an ohmic contact of metal silicide.

Abstract: A monolithic high power radio frequency switch includes a substrate, and first and second gallium nitride high electron mobility transistors on the substrate. Each of the first and second gallium nitride high electron mobility transistors includes a respective source, drain and gate terminal. The source terminal of the first gallium nitride high electron mobility transistor is coupled to the drain terminal of the second gallium nitride high electron mobility transistor, and the source terminal of the second gallium nitride high electron mobility transistor is coupled to ground. An RF input pad is coupled to the drain terminal of the first second gallium nitride high electron mobility transistor, an RF output pad is coupled to the source terminal of the first gallium nitride high electron mobility transistor and the drain terminal of the second gallium nitride high electron mobility transistor, and a control pad is coupled to the gate of the first gallium nitride high electron mobility transistor.