Abstract: A tooth for a toothed torque transmission assembly includes a tooth flank designed for torque exchange with a counter flank of a meshing partner. The tooth flank includes a periodically extending tooth flank correction including a sinusoidal corrugation having a locally extending period length T, wherein a development of the sinusoidal corrugation of the periodically extending tooth flank correction defines a center line. The periodic tooth flank correction is overlaid with a spatial microstructure having a local maxima and/or a local minima and a shortest distance t of t<T/2 between the local maxima and/or the local minima with respect to the center line. A formation of the microstructure is dimensioned to generate additional structure-borne sound in running operation of the torque transmission assembly to mask a tonality in the emitted structure-borne sound.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: An actuator for a magnet valve, the actuator including a housing including a terminal wall including an opening; and an armature arranged in the housing and movable in an axial linear manner between a first end position and a second end position, wherein the opening is closed by a terminal cover, wherein the terminal cover includes a contour that protrudes at least in a direction towards the armature, and wherein the contour includes a first section that defines the second end position of the armature.

Abstract: An actuator for a hydraulic stroke or pressure control valve for a motor vehicle, the actuator including a magnetisable actuator housing that envelops a magnet coil; a pole group arranged in a receiving opening of the actuator housing, wherein the pole group includes a pole core and a pole tube, wherein an axially movable armature is arranged in an inner cavity of the pole group, wherein the armature is configured to axially move a piston of the hydraulic valve by a pin that is supported axially movable in the pole group, wherein the actuator is configured to perform an anti-stick function and a contact damping function, wherein the pin directly contacts a first armature face of the armature that is oriented towards the pin, and wherein the pin is configured axially movable relative to the armature.

Abstract: A hydraulic valve including a valve housing; and a valve piston that is axially movable in the valve housing along a first longitudinal axis of the valve housing, wherein the valve housing includes a supply connection for feeding a hydraulic fluid, at least one operating connection and at least one tank connection for draining the hydraulic fluid, wherein the valve piston is movable by an electromagnetic actuator of the hydraulic valve, wherein the valve housing forms a hydraulic portion and the actuator forms a magnet portion of the hydraulic valve, wherein a divider element is arranged between the hydraulic portion and the magnet portion, and wherein the divider element is configured to provide a flow connection between the hydraulic portion and the magnet portion and vice versa.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: This invention describes large microwave/radiofrequency (RF/MW) heating equipments scalable to any size heated with RF/MW heating systems employing multiple magnetrons independent of its wave characteristics arranged in a particular fashion to avoid wave interferences and concentrated heating without turn tables. The invention also explains the various embodiments of the invention like solvent dehydration and solvent recovery using the above mentioned invention.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: An actuator for a hydraulic stroke or pressure control valve for a motor vehicle, the actuator including a magnetisable actuator housing that envelops a magnet coil; a pole group arranged in a receiving opening of the actuator housing, wherein the pole group includes a pole core and a pole tube, wherein an axially movable armature is arranged in an inner cavity of the pole group, wherein the armature is configured to axially move a piston of the hydraulic valve by a pin that is supported axially movable in the pole group, wherein the actuator is configured to perform an anti-stick function and a contact damping function, wherein the pin directly contacts a first armature face of the armature that is oriented towards the pin, and wherein the pin is configured axially movable relative to the armature.

Abstract: An actuator for a magnet valve, the actuator including a housing including a terminal wall including an opening; and an armature arranged in the housing and movable in an axial linear manner between a first end position and a second end position, wherein the opening is closed by a terminal cover, wherein the terminal cover includes a contour that protrudes at least in a direction towards the armature, and wherein the contour includes a first section that defines the second end position of the armature.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.

Abstract: Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins such as tyrosine kinases (TKs) and downstream proteins in TK signal transduction pathways (e.g., TK pathway proteins). In various embodiments, the methods, apparatuses, and systems may use nanoparticles, such as quantum dots (QD), to detect and/or characterize the abnormally overactive TK signaling pathways that underlie tumorgenesis and tumor progression. In various embodiments, the QD-based methods, apparatuses, and systems may have a sufficiently high degree of sensitivity to enable the identification of new TK signaling pathway markers, for example for use in diagnosing, staging, monitoring, and/or prognosing cancers, or in evaluating the efficacy of cancer therapeutics.

Abstract: A hydraulic valve including a valve housing; and a valve piston that is axially movable in the valve housing along a first longitudinal axis of the valve housing, wherein the valve housing includes a supply connection for feeding a hydraulic fluid, at least one operating connection and at least one tank connection for draining the hydraulic fluid, wherein the valve piston is movable by an electromagnetic actuator of the hydraulic valve, wherein the valve housing forms a hydraulic portion and the actuator forms a magnet portion of the hydraulic valve, wherein a divider element is arranged between the hydraulic portion and the magnet portion, and wherein the divider element is configured to provide a flow connection between the hydraulic portion and the magnet portion and vice versa.

Abstract: Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins such as tyrosine kinases (TKs) and downstream proteins in TK signal transduction pathways (e.g., TK pathway proteins). In various embodiments, the methods, apparatuses, and systems may use nanoparticles, such as quantum dots (QD), to detect and/or characterize the abnormally overactive TK signaling pathways that underlie tumorgenesis and tumor progression. In various embodiments, the QD-based methods, apparatuses, and systems may have a sufficiently high degree of sensitivity to enable the identification of new TK signaling pathway markers, for example for use in diagnosing, staging, monitoring, and/or prognosing cancers, or in evaluating the efficacy of cancer therapeutics.

Abstract: A clip filter for a hydraulic valve, the clip filter comprising a carrier frame; and filter elements received in the carrier frame, wherein the carrier frame is configured annular and includes a clip filter lock, wherein a first end of the carrier frame and a second end of the carrier frame are engageable with each other for closing the clip filter, wherein the first end of the carrier frame includes a lug shaped clip element and the second end of the carrier frame includes a recess that is complementary to the lug shaped clip element, and wherein a clip filter lock is configured for a maximized opening force.

Abstract: A hydraulic valve including a valve bushing; a valve piston that is axially moveable in the valve bushing along a longitudinal axis of the valve bushing; a supply connection configured to feed a hydraulic fluid; at least one operating connection; and at least one tank drain configured to drain the hydraulic fluid, wherein the valve piston is movable by an electromagnetic actuator of the hydraulic valve and the valve bushing forms a hydraulic portion and the actuator forms a magnetic portion of the hydraulic valve, characterized in that a seal element is arranged in the valve bushing which seal element provides a spatial separation of the magnet portion and the hydraulic portion, and wherein the seal element is penetrated by an end of the valve piston configured as a piston plunger.

Abstract: Methods and systems for quantifying cellular activity using labeled probes, e.g., quantum dots, are disclosed. In one example approach, a method for quantifying cellular activity in a sample containing intact cells having labeled complexes comprises receiving images of the sample at a plurality of depths and detecting individual intact cells in the images of the sample at the plurality of depths. For each detected cell, discrete labels may be detected and localized in the cell at each depth, a total number of detected and localized labels may be calculated in the cell, and an activity level of the target molecule for the labeled probe in the cell determined.